Fas-Dependent Elimination of Nonselected CD8 Cells and lpr Disease

MHC/self peptide interactions with cognate coreceptor/TCR complexes are central to homeostasis of the T cell repertoire. Recent reports have also underlined the critical role of IL-15/IL-2 cytokines in regulating this homeostatic process. In this study, we investigate mechanisms that regulate potent...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-05, Vol.168 (10), p.4960-4967
Hauptverfasser:	Trimble, Linda A, Prince, Kenya A, Pestano, Gary A, Daley, John, Cantor, Harvey
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Cell Cycle - genetics Cell Cycle - immunology Cell Death - genetics Cell Death - immunology Cell Differentiation - genetics Cell Differentiation - immunology Cell Movement - genetics Cell Movement - immunology Clonal Deletion - genetics DNA-Binding Proteins - metabolism fas Receptor - genetics fas Receptor - physiology Female H-2 Antigens - metabolism Homeostasis - genetics Homeostasis - immunology Hyaluronan Receptors - biosynthesis Leukocyte Common Antigens - biosynthesis Lymphoproliferative Disorders - genetics Lymphoproliferative Disorders - immunology Lymphoproliferative Disorders - pathology Male Mice Mice, Inbred C57BL Mice, Inbred MRL lpr Mice, Transgenic Peptide Fragments - metabolism Receptors, Interleukin-2 - biosynthesis Receptors, Interleukin-2 - physiology Signal Transduction - genetics Signal Transduction - immunology Thymus Gland - immunology Thymus Gland - metabolism Thymus Gland - pathology Up-Regulation - genetics Up-Regulation - immunology
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