Differential Regulation of Th1-Type and Th2-Type Cytokine Profiles in Pancreatic Islets of C57BL/6 and BALB/c Mice by Multiple Low Doses of Streptozotocin
In the nonobese diabetic (NOD) mouse, the T helper (Th)1-type inflammatory cytokines interferon (IFN)-g and tumor necrosis factor (TNF)-a play a critical role in the development of type 1 diabetes, whereas the Th2-type anti-inflammatory cytokines interleukin (IL)-4 and IL-10 operate counterregulator...
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| Veröffentlicht in: | Immunobiology (1979) 2002-03, Vol.205 (1), p.35-50 |
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| creator | Müller, Andreas Schott-Ohly, Patricia Dohle, Claudia Gleichmann, Helga |
| description | In the nonobese diabetic (NOD) mouse, the T helper (Th)1-type inflammatory cytokines interferon (IFN)-g and tumor necrosis factor (TNF)-a play a critical role in the development of type 1 diabetes, whereas the Th2-type anti-inflammatory cytokines interleukin (IL)-4 and IL-10 operate counterregulatory. There are no comprehensive analyses on cytokine profiles in the mouse model of diabetes induced with multiple low doses of streptozotocin (MLD-STZ). Therefore, we used islets to study
ex vivo effects of MLD-STZ and
in vitro effects of STZ on IFN-g, TNF-a, IL-4, and IL-10 on both levels of protein-producing cells and the mRNA expression, as well as the mRNA expression of the Th3-type cytokine transforming growth factor TGF-b1. C57BL/6 and BALB/c mice of both genders were injected intraperitoneally with 40 mg/kg body wt STZ on five consecutive days and islets were isolated on day 1 and 3 after the fifth STZ-injection. Control mice received the solvent of STZ. In islets of C57BL/6 mice of both genders MLD-STZ similarly stimulated production of IFN-g and TNF-a, but significantly reduced IL-4 and IL-10 levels in male mice only. Opposite results were obtained in islets of BALB/c mice of both genders. Here, MLD-STZ markedly decreased the levels of IFN-g and TNF-a, but significantly increased the levels of IL-4 and IL-10. The functional results were in line with MLD-STZ effects on the mRNA expression of the cytokines. |
| doi_str_mv | 10.1078/0171-2985-00109 |
| format | Article |
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ex vivo effects of MLD-STZ and
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ex vivo effects of MLD-STZ and
in vitro effects of STZ on IFN-g, TNF-a, IL-4, and IL-10 on both levels of protein-producing cells and the mRNA expression, as well as the mRNA expression of the Th3-type cytokine transforming growth factor TGF-b1. C57BL/6 and BALB/c mice of both genders were injected intraperitoneally with 40 mg/kg body wt STZ on five consecutive days and islets were isolated on day 1 and 3 after the fifth STZ-injection. Control mice received the solvent of STZ. In islets of C57BL/6 mice of both genders MLD-STZ similarly stimulated production of IFN-g and TNF-a, but significantly reduced IL-4 and IL-10 levels in male mice only. Opposite results were obtained in islets of BALB/c mice of both genders. Here, MLD-STZ markedly decreased the levels of IFN-g and TNF-a, but significantly increased the levels of IL-4 and IL-10. The functional results were in line with MLD-STZ effects on the mRNA expression of the cytokines.</description><subject>Animals</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - genetics</subject><subject>Diabetes Mellitus, Experimental - genetics</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Female</subject><subject>In Vitro Techniques</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interferon-gamma - genetics</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-10 - genetics</subject><subject>Interleukin-4 - biosynthesis</subject><subject>Interleukin-4 - genetics</subject><subject>Islets of Langerhans - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Sex Factors</subject><subject>Species Specificity</subject><subject>Streptozocin</subject><subject>Th1 Cells - immunology</subject><subject>Th1 Cells - metabolism</subject><subject>Th2 Cells - immunology</subject><subject>Th2 Cells - metabolism</subject><subject>Transforming Growth Factor beta - biosynthesis</subject><subject>Transforming Growth Factor beta - genetics</subject><subject>Transforming Growth Factor beta1</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><issn>0171-2985</issn><issn>1878-3279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUGP0zAQhS0EYsvCmRuyOHALtePEjo_bLgsrZcUKytlynAl4Se1iO6zKT-HX4rQVSEiI02jG33vS80PoOSWvKRHNklBBi1I2dUEIJfIBWtBGNAUrhXyIFr9fz9CTGO8yIkvRPEZnlEopWcUW6OelHQYI4JLVI_4An6dRJ-sd9gPefKHFZr8DrF2fl_K4rPfJf7UO8G3wgx0hYuvwrXYmQFYafB1HSHHWr2uxapf8IF9dtKulwTfWAO72-GYak92NgFt_jy99hIPgYwqwS_6HT95Y9xQ9GvQY4dlpnqNPV28263dF-_7t9fqiLUzFRcr5SDVUTDbl0OeopaEgq1pCT4eeVILXvNElo1Lns6m6rmw6RlgHnPZGV7xm5-jV0XcX_LcJYlJbGw2Mo3bgp6gE5ZxIwf8L0obJuuYz-PIv8M5PweUQqqQVKRnnNEPLI2SCjzHAoHbBbnXYK0rUXK6a61NzfepQbla8ONlO3Rb6P_ypzQzIIwD5u75bCCoaC85AbwOYpHpv_2n-C0nFr00</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Müller, Andreas</creator><creator>Schott-Ohly, Patricia</creator><creator>Dohle, Claudia</creator><creator>Gleichmann, Helga</creator><general>Elsevier GmbH</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Differential Regulation of Th1-Type and Th2-Type Cytokine Profiles in Pancreatic Islets of C57BL/6 and BALB/c Mice by Multiple Low Doses of Streptozotocin</title><author>Müller, Andreas ; Schott-Ohly, Patricia ; Dohle, Claudia ; Gleichmann, Helga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-2904f43982fd9852c1e9459ed1fd0476568a2319ae94c4bb28b303be61dca4653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - genetics</topic><topic>Diabetes Mellitus, Experimental - genetics</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Female</topic><topic>In Vitro Techniques</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interferon-gamma - genetics</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Interleukin-10 - genetics</topic><topic>Interleukin-4 - biosynthesis</topic><topic>Interleukin-4 - genetics</topic><topic>Islets of Langerhans - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Sex Factors</topic><topic>Species Specificity</topic><topic>Streptozocin</topic><topic>Th1 Cells - immunology</topic><topic>Th1 Cells - metabolism</topic><topic>Th2 Cells - immunology</topic><topic>Th2 Cells - metabolism</topic><topic>Transforming Growth Factor beta - biosynthesis</topic><topic>Transforming Growth Factor beta - genetics</topic><topic>Transforming Growth Factor beta1</topic><topic>Tumor Necrosis Factor-alpha - 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Academic</collection><jtitle>Immunobiology (1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Müller, Andreas</au><au>Schott-Ohly, Patricia</au><au>Dohle, Claudia</au><au>Gleichmann, Helga</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Regulation of Th1-Type and Th2-Type Cytokine Profiles in Pancreatic Islets of C57BL/6 and BALB/c Mice by Multiple Low Doses of Streptozotocin</atitle><jtitle>Immunobiology (1979)</jtitle><addtitle>Immunobiology</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>205</volume><issue>1</issue><spage>35</spage><epage>50</epage><pages>35-50</pages><issn>0171-2985</issn><eissn>1878-3279</eissn><abstract>In the nonobese diabetic (NOD) mouse, the T helper (Th)1-type inflammatory cytokines interferon (IFN)-g and tumor necrosis factor (TNF)-a play a critical role in the development of type 1 diabetes, whereas the Th2-type anti-inflammatory cytokines interleukin (IL)-4 and IL-10 operate counterregulatory. There are no comprehensive analyses on cytokine profiles in the mouse model of diabetes induced with multiple low doses of streptozotocin (MLD-STZ). Therefore, we used islets to study
ex vivo effects of MLD-STZ and
in vitro effects of STZ on IFN-g, TNF-a, IL-4, and IL-10 on both levels of protein-producing cells and the mRNA expression, as well as the mRNA expression of the Th3-type cytokine transforming growth factor TGF-b1. C57BL/6 and BALB/c mice of both genders were injected intraperitoneally with 40 mg/kg body wt STZ on five consecutive days and islets were isolated on day 1 and 3 after the fifth STZ-injection. Control mice received the solvent of STZ. In islets of C57BL/6 mice of both genders MLD-STZ similarly stimulated production of IFN-g and TNF-a, but significantly reduced IL-4 and IL-10 levels in male mice only. Opposite results were obtained in islets of BALB/c mice of both genders. Here, MLD-STZ markedly decreased the levels of IFN-g and TNF-a, but significantly increased the levels of IL-4 and IL-10. The functional results were in line with MLD-STZ effects on the mRNA expression of the cytokines.</abstract><cop>Netherlands</cop><pub>Elsevier GmbH</pub><pmid>11999343</pmid><doi>10.1078/0171-2985-00109</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Immunobiology (1979), 2002-03, Vol.205 (1), p.35-50 |
| issn | 0171-2985 1878-3279 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Animals Cytokines - biosynthesis Cytokines - genetics Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Female In Vitro Techniques Interferon-gamma - biosynthesis Interferon-gamma - genetics Interleukin-10 - biosynthesis Interleukin-10 - genetics Interleukin-4 - biosynthesis Interleukin-4 - genetics Islets of Langerhans - metabolism Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Sex Factors Species Specificity Streptozocin Th1 Cells - immunology Th1 Cells - metabolism Th2 Cells - immunology Th2 Cells - metabolism Transforming Growth Factor beta - biosynthesis Transforming Growth Factor beta - genetics Transforming Growth Factor beta1 Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics |
| title | Differential Regulation of Th1-Type and Th2-Type Cytokine Profiles in Pancreatic Islets of C57BL/6 and BALB/c Mice by Multiple Low Doses of Streptozotocin |
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