Elevated levels of PtdIns5P in NPM-ALK transformed cells: Implication of PIKfyve
Phosphatidylinositol 5-monophosphate (PtdIns5P), one of the latest phosphoinositides discovered, has been suggested to play important cellular functions. Here, we report the presence of higher levels of this lipid in cells expressing the oncogenic tyrosine kinase nucleophosmin anaplastic lymphoma ki...
Gespeichert in:
| Veröffentlicht in: | Biochemical and biophysical research communications 2008-07, Vol.372 (2), p.351-355 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 355 |
|---|---|
| container_issue | 2 |
| container_start_page | 351 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 372 |
| creator | Coronas, S. Lagarrigue, F. Ramel, D. Chicanne, G. Delsol, G. Payrastre, B. Tronchère, H. |
| description | Phosphatidylinositol 5-monophosphate (PtdIns5P), one of the latest phosphoinositides discovered, has been suggested to play important cellular functions. Here, we report the presence of higher levels of this lipid in cells expressing the oncogenic tyrosine kinase nucleophosmin anaplastic lymphoma kinase (NPM-ALK), a chimeric protein found in the large majority of anaplastic large cell lymphomas (ALCLs). In addition, we describe that a pool of PtdIns5P is located in the membrane extensions characteristic of NPM-ALK-transformed cells. Finally, we show that the increase of PtdIns5P is controlled by the kinase PIKfyve, which is known for its role in vesicular trafficking. These data suggest for the first time a role of PtdIns5P and PIKfyve in oncogenesis, potentially linking intracellular trafficking to cancer. |
| doi_str_mv | 10.1016/j.bbrc.2008.05.062 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71660857</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X08009509</els_id><sourcerecordid>20780453</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-19bc57fb6207bd9061a0c9ecbf001d4764384a5f9c654d02ae73a0758fa95ca53</originalsourceid><addsrcrecordid>eNqFkE9LwzAchoMobk6_gAfpyVvrL22TtOJljKljU3tQ8BbSNIGM_plJN9i3N3UDb3p6L8_78vIgdI0hwoDp3ToqSyujGCCLgERA4xM0xpBDGGNIT9EYAGgY5_hzhC6cWwNgnNL8HI1wRgAzSMaomNdqJ3pVBT5V7YJOB0VfLVpHisC0wWvxEk5Xy6C3onW6s40npaprdx8smk1tpOhN1_60Fku936lLdKZF7dTVMSfo43H-PnsOV29Pi9l0FcokI32I81ISpksaAyurHCgWIHMlS-1fVimjaZKlguhcUpJWEAvFEgGMZFrkRAqSTNDtYXdju6-tcj1vjBueiVZ1W8cZphQywv4F_YEMUpJ4MD6A0nbOWaX5xppG2D3HwAfhfM0H4XwQzoFwL9yXbo7r29K7-a0cDXvg4QB4uWpnlOVOGtVKVRmrZM-rzvy1_w2Nk4-z</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20780453</pqid></control><display><type>article</type><title>Elevated levels of PtdIns5P in NPM-ALK transformed cells: Implication of PIKfyve</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Coronas, S. ; Lagarrigue, F. ; Ramel, D. ; Chicanne, G. ; Delsol, G. ; Payrastre, B. ; Tronchère, H.</creator><creatorcontrib>Coronas, S. ; Lagarrigue, F. ; Ramel, D. ; Chicanne, G. ; Delsol, G. ; Payrastre, B. ; Tronchère, H.</creatorcontrib><description>Phosphatidylinositol 5-monophosphate (PtdIns5P), one of the latest phosphoinositides discovered, has been suggested to play important cellular functions. Here, we report the presence of higher levels of this lipid in cells expressing the oncogenic tyrosine kinase nucleophosmin anaplastic lymphoma kinase (NPM-ALK), a chimeric protein found in the large majority of anaplastic large cell lymphomas (ALCLs). In addition, we describe that a pool of PtdIns5P is located in the membrane extensions characteristic of NPM-ALK-transformed cells. Finally, we show that the increase of PtdIns5P is controlled by the kinase PIKfyve, which is known for its role in vesicular trafficking. These data suggest for the first time a role of PtdIns5P and PIKfyve in oncogenesis, potentially linking intracellular trafficking to cancer.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2008.05.062</identifier><identifier>PMID: 18501703</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anaplastic large-cell lymphoma ; Animals ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - metabolism ; Humans ; Mice ; NIH 3T3 Cells ; NPM-ALK ; Oncogenesis ; Phosphatidylinositol 3-Kinases - metabolism ; Phosphatidylinositol 5-phosphate ; Phosphatidylinositol Phosphates - analysis ; Phosphatidylinositol Phosphates - metabolism ; PIKfyve ; Protein-Tyrosine Kinases - genetics ; Protein-Tyrosine Kinases - metabolism</subject><ispartof>Biochemical and biophysical research communications, 2008-07, Vol.372 (2), p.351-355</ispartof><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-19bc57fb6207bd9061a0c9ecbf001d4764384a5f9c654d02ae73a0758fa95ca53</citedby><cites>FETCH-LOGICAL-c385t-19bc57fb6207bd9061a0c9ecbf001d4764384a5f9c654d02ae73a0758fa95ca53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2008.05.062$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18501703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coronas, S.</creatorcontrib><creatorcontrib>Lagarrigue, F.</creatorcontrib><creatorcontrib>Ramel, D.</creatorcontrib><creatorcontrib>Chicanne, G.</creatorcontrib><creatorcontrib>Delsol, G.</creatorcontrib><creatorcontrib>Payrastre, B.</creatorcontrib><creatorcontrib>Tronchère, H.</creatorcontrib><title>Elevated levels of PtdIns5P in NPM-ALK transformed cells: Implication of PIKfyve</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Phosphatidylinositol 5-monophosphate (PtdIns5P), one of the latest phosphoinositides discovered, has been suggested to play important cellular functions. Here, we report the presence of higher levels of this lipid in cells expressing the oncogenic tyrosine kinase nucleophosmin anaplastic lymphoma kinase (NPM-ALK), a chimeric protein found in the large majority of anaplastic large cell lymphomas (ALCLs). In addition, we describe that a pool of PtdIns5P is located in the membrane extensions characteristic of NPM-ALK-transformed cells. Finally, we show that the increase of PtdIns5P is controlled by the kinase PIKfyve, which is known for its role in vesicular trafficking. These data suggest for the first time a role of PtdIns5P and PIKfyve in oncogenesis, potentially linking intracellular trafficking to cancer.</description><subject>Anaplastic large-cell lymphoma</subject><subject>Animals</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Humans</subject><subject>Mice</subject><subject>NIH 3T3 Cells</subject><subject>NPM-ALK</subject><subject>Oncogenesis</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Phosphatidylinositol 5-phosphate</subject><subject>Phosphatidylinositol Phosphates - analysis</subject><subject>Phosphatidylinositol Phosphates - metabolism</subject><subject>PIKfyve</subject><subject>Protein-Tyrosine Kinases - genetics</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9LwzAchoMobk6_gAfpyVvrL22TtOJljKljU3tQ8BbSNIGM_plJN9i3N3UDb3p6L8_78vIgdI0hwoDp3ToqSyujGCCLgERA4xM0xpBDGGNIT9EYAGgY5_hzhC6cWwNgnNL8HI1wRgAzSMaomNdqJ3pVBT5V7YJOB0VfLVpHisC0wWvxEk5Xy6C3onW6s40npaprdx8smk1tpOhN1_60Fku936lLdKZF7dTVMSfo43H-PnsOV29Pi9l0FcokI32I81ISpksaAyurHCgWIHMlS-1fVimjaZKlguhcUpJWEAvFEgGMZFrkRAqSTNDtYXdju6-tcj1vjBueiVZ1W8cZphQywv4F_YEMUpJ4MD6A0nbOWaX5xppG2D3HwAfhfM0H4XwQzoFwL9yXbo7r29K7-a0cDXvg4QB4uWpnlOVOGtVKVRmrZM-rzvy1_w2Nk4-z</recordid><startdate>20080725</startdate><enddate>20080725</enddate><creator>Coronas, S.</creator><creator>Lagarrigue, F.</creator><creator>Ramel, D.</creator><creator>Chicanne, G.</creator><creator>Delsol, G.</creator><creator>Payrastre, B.</creator><creator>Tronchère, H.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20080725</creationdate><title>Elevated levels of PtdIns5P in NPM-ALK transformed cells: Implication of PIKfyve</title><author>Coronas, S. ; Lagarrigue, F. ; Ramel, D. ; Chicanne, G. ; Delsol, G. ; Payrastre, B. ; Tronchère, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-19bc57fb6207bd9061a0c9ecbf001d4764384a5f9c654d02ae73a0758fa95ca53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anaplastic large-cell lymphoma</topic><topic>Animals</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Humans</topic><topic>Mice</topic><topic>NIH 3T3 Cells</topic><topic>NPM-ALK</topic><topic>Oncogenesis</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Phosphatidylinositol 5-phosphate</topic><topic>Phosphatidylinositol Phosphates - analysis</topic><topic>Phosphatidylinositol Phosphates - metabolism</topic><topic>PIKfyve</topic><topic>Protein-Tyrosine Kinases - genetics</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coronas, S.</creatorcontrib><creatorcontrib>Lagarrigue, F.</creatorcontrib><creatorcontrib>Ramel, D.</creatorcontrib><creatorcontrib>Chicanne, G.</creatorcontrib><creatorcontrib>Delsol, G.</creatorcontrib><creatorcontrib>Payrastre, B.</creatorcontrib><creatorcontrib>Tronchère, H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coronas, S.</au><au>Lagarrigue, F.</au><au>Ramel, D.</au><au>Chicanne, G.</au><au>Delsol, G.</au><au>Payrastre, B.</au><au>Tronchère, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated levels of PtdIns5P in NPM-ALK transformed cells: Implication of PIKfyve</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2008-07-25</date><risdate>2008</risdate><volume>372</volume><issue>2</issue><spage>351</spage><epage>355</epage><pages>351-355</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Phosphatidylinositol 5-monophosphate (PtdIns5P), one of the latest phosphoinositides discovered, has been suggested to play important cellular functions. Here, we report the presence of higher levels of this lipid in cells expressing the oncogenic tyrosine kinase nucleophosmin anaplastic lymphoma kinase (NPM-ALK), a chimeric protein found in the large majority of anaplastic large cell lymphomas (ALCLs). In addition, we describe that a pool of PtdIns5P is located in the membrane extensions characteristic of NPM-ALK-transformed cells. Finally, we show that the increase of PtdIns5P is controlled by the kinase PIKfyve, which is known for its role in vesicular trafficking. These data suggest for the first time a role of PtdIns5P and PIKfyve in oncogenesis, potentially linking intracellular trafficking to cancer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18501703</pmid><doi>10.1016/j.bbrc.2008.05.062</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 2008-07, Vol.372 (2), p.351-355 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71660857 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anaplastic large-cell lymphoma Animals Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Humans Mice NIH 3T3 Cells NPM-ALK Oncogenesis Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol 5-phosphate Phosphatidylinositol Phosphates - analysis Phosphatidylinositol Phosphates - metabolism PIKfyve Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism |
| title | Elevated levels of PtdIns5P in NPM-ALK transformed cells: Implication of PIKfyve |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T12%3A41%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Elevated%20levels%20of%20PtdIns5P%20in%20NPM-ALK%20transformed%20cells:%20Implication%20of%20PIKfyve&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Coronas,%20S.&rft.date=2008-07-25&rft.volume=372&rft.issue=2&rft.spage=351&rft.epage=355&rft.pages=351-355&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1016/j.bbrc.2008.05.062&rft_dat=%3Cproquest_cross%3E20780453%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20780453&rft_id=info:pmid/18501703&rft_els_id=S0006291X08009509&rfr_iscdi=true |