Signal Transductions Induced by Bone Morphogenetic Protein-2 and Transforming Growth Factor-β in Normal Human Osteoblastic Cells

Transforming growth factor β (TGF-β) activates Ras/MAPK signaling in many cell types. Because TGF-β and BMP-2 exert similar effects, we examined if this signaling is stimulated by both factors and analyzed the relationship between this signaling and the Smads in osteoblasts. BMP-2 and TGF-β stimulat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2002-05, Vol.277 (18), p.15514-15522
Hauptverfasser:	Lai, Chung-Fang, Cheng, Su-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - pharmacology Cell Culture Techniques - methods Cell Nucleus - metabolism Cells, Cultured Collagen Type I - metabolism Enhancer Elements, Genetic extracellular signal-regulated kinase Fibronectins - metabolism Humans Mice Mitogen-Activated Protein Kinases - metabolism Osteoblasts - drug effects Osteoblasts - physiology Osteopontin p38 protein Protease Inhibitors - pharmacology ras Proteins - metabolism Recombinant Fusion Proteins - metabolism Recombinant Proteins - pharmacology Sialoglycoproteins - metabolism Signal Transduction - drug effects Transcription Factor AP-1 - genetics Transfection Transforming Growth Factor beta - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!