The role of iron and copper in the aetiology of neurodegenerative disorders: Therapeutic implications

Abnormalities in the metabolism of the transition metals iron and copper have been demonstrated to play a crucial role in the pathogenesis of various neurodegenerative diseases. Metal homeostasis as it pertains to alterations in brain function in neurodegenerative diseases is reviewed in this articl...

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Veröffentlicht in:	CNS drugs 2002, Vol.16 (5), p.339-352
Hauptverfasser:	PERRY, George, SAYRE, Lawrence M, ATWOOD, Craig S, CASTELLANI, Rudolph J, CASH, Adam D, ROTTKAMP, Catherine A, SMITH, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - etiology Alzheimer Disease - metabolism Amyotrophic Lateral Sclerosis - drug therapy Amyotrophic Lateral Sclerosis - etiology Amyotrophic Lateral Sclerosis - metabolism Antioxidants - therapeutic use Biological and medical sciences Chelating Agents - therapeutic use Copper - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Free Radicals - metabolism Homeostasis Humans Iron - metabolism Medical sciences Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - etiology Neurodegenerative Diseases - metabolism Neurology Oxidation-Reduction Oxidative Stress Parkinson Disease - drug therapy Parkinson Disease - etiology Parkinson Disease - metabolism Prion Diseases - drug therapy Prion Diseases - etiology Prion Diseases - metabolism
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