Messenger-RNA-binding proteins and the messages they carry

From sites of transcription in the nucleus to the outreaches of the cytoplasm, messenger RNAs are associated with RNA-binding proteins. These proteins influence pre-mRNA processing as well as the transport, localization, translation and stability of mRNAs. Recent discoveries have shown that one grou...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2002-03, Vol.3 (3), p.195-205
Hauptverfasser:	Dreyfuss, Gideon, Kim, V. Narry, Kataoka, Naoyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biosynthesis Cytoplasm Cytoplasm - metabolism Exons Heterogeneous-Nuclear Ribonucleoproteins hnRNA Humans Localization Models, Biological Mutation Proteins Ribonucleic acid Ribonucleoproteins - metabolism RNA RNA polymerase RNA Splicing RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - metabolism Surveillance
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Beschreibung
Zusammenfassung:	From sites of transcription in the nucleus to the outreaches of the cytoplasm, messenger RNAs are associated with RNA-binding proteins. These proteins influence pre-mRNA processing as well as the transport, localization, translation and stability of mRNAs. Recent discoveries have shown that one group of these proteins marks exon exon junctions and has a role in mRNA export. These proteins communicate crucial information to the translation machinery for the surveillance of nonsense mutations and for mRNA localization and translation.
ISSN:	1471-0072 1471-0080
DOI:	10.1038/nrm760