Curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor

Curcumin (diferuoylmethane or 1,7-bis (4-hydroxy-3-methoxyphenol)-1,6-hepatadiene-3,5-dione) is the active ingredient of the spice turmeric. Curcumin has been shown to have a number of pharmacological and therapeutic uses. This study shows that curcumin is a potent inhibitor of the inositol 1,4,5-tr...

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Veröffentlicht in:	Cell calcium (Edinburgh) 2002-01, Vol.31 (1), p.45-52
Hauptverfasser:	Dyer, J.L., Zafar Khan, S., Bilmen, J.G., Hawtin, S.R., Wheatley, M., Javed, M.-ul-H., Michelangeli, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacology Calcium - metabolism Calcium Channels - metabolism Cerebellum - metabolism Curcumin - metabolism Curcumin - pharmacology In Vitro Techniques Inositol 1,4,5-Trisphosphate - metabolism Inositol 1,4,5-Trisphosphate Receptors Kinetics Microsomes - metabolism Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Receptors, Cytoplasmic and Nuclear - metabolism Swine Tritium
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