Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation

Local physical interactions between cells and extracellular matrix (ECM) influence directional cell motility that is critical for tissue development, wound repair, and cancer metastasis. Here we test the possibility that the precise spatial positioning of focal adhesions governs the direction in whi...

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Veröffentlicht in:	The FASEB journal 2008-06, Vol.22 (6), p.1649-1659
Hauptverfasser:	Xia, Nan, Thodeti, Charles K., Hunt, Tom P., Xu, Qiaobing, Ho, Madelyn, Whitesides, George M., Westervelt, Robert, Ingber, Donald E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion Cell Movement Cell Surface Extensions - metabolism cytoskeleton extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix - ultrastructure Fluorescence Resonance Energy Transfer Focal Adhesions mechanical Mice microcontact printing migration NIH 3T3 Cells rac GTP-Binding Proteins - metabolism traction
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