Neurofibrillary tangles in elderly patients with late onset schizophrenia
The objective of the present study was to examine whether neurofibrillary tangles densities are increased in elderly patients with late-onset schizophrenia (LOS). A neuropathological examination was performed in 32 consecutive autopsy brain specimens of ten patients with early-onset schizophrenia (E...
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| Veröffentlicht in: | Neuroscience letters 2002-05, Vol.324 (2), p.109-112 |
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| creator | Bozikas, Vasilis P Kövari, Enikö Bouras, Constantin Karavatos, Athanasios |
| description | The objective of the present study was to examine whether neurofibrillary tangles densities are increased in elderly patients with late-onset schizophrenia (LOS). A neuropathological examination was performed in 32 consecutive autopsy brain specimens of ten patients with early-onset schizophrenia (EOS; onset of symptoms before the age of 40 years), eight patients with LOS (onset of symptoms after the age of 40 years) and 14 age-matched controls with no known neuropsychiatric disorder. Neurofibrillary tangle densities observed in the CA1 field of the hippocampus, the enthorhinal cortex, and the inferior temporal cortex in patients with LOS, EOS, and controls were not significantly different. All patients with EOS or LOS had Braak stages of III or less, which may correspond to normal aging. Thus, patients with schizophrenia, regardless of the age of onset of their symptoms, are no more prone to the development of Alzheimer's disease than the general population. |
| doi_str_mv | 10.1016/S0304-3940(02)00189-1 |
| format | Article |
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A neuropathological examination was performed in 32 consecutive autopsy brain specimens of ten patients with early-onset schizophrenia (EOS; onset of symptoms before the age of 40 years), eight patients with LOS (onset of symptoms after the age of 40 years) and 14 age-matched controls with no known neuropsychiatric disorder. Neurofibrillary tangle densities observed in the CA1 field of the hippocampus, the enthorhinal cortex, and the inferior temporal cortex in patients with LOS, EOS, and controls were not significantly different. All patients with EOS or LOS had Braak stages of III or less, which may correspond to normal aging. Thus, patients with schizophrenia, regardless of the age of onset of their symptoms, are no more prone to the development of Alzheimer's disease than the general population.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(02)00189-1</identifier><identifier>PMID: 11988339</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult and adolescent clinical studies ; Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease - complications ; Alzheimer Disease - epidemiology ; Alzheimer Disease - pathology ; Alzheimer's disease ; Biological and medical sciences ; Cognition Disorders - epidemiology ; Cognition Disorders - etiology ; Cognition Disorders - pathology ; Disease Progression ; Hippocampus - pathology ; Hippocampus - physiopathology ; Humans ; Late-onset schizophrenia ; Medical sciences ; Middle Aged ; Neocortex - pathology ; Neocortex - physiopathology ; Neurofibrillary tangles ; Neurofibrillary Tangles - pathology ; Neurons - pathology ; Neuropathology ; Plaque, Amyloid - pathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - complications ; Schizophrenia - epidemiology ; Schizophrenia - pathology ; Temporal Lobe - pathology ; Temporal Lobe - physiopathology</subject><ispartof>Neuroscience letters, 2002-05, Vol.324 (2), p.109-112</ispartof><rights>2002</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-e21185f6716499b89efe8f2ccba08c9f477f7a0fa7805816a08547d3d258d2a53</citedby><cites>FETCH-LOGICAL-c422t-e21185f6716499b89efe8f2ccba08c9f477f7a0fa7805816a08547d3d258d2a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(02)00189-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13637610$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11988339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bozikas, Vasilis P</creatorcontrib><creatorcontrib>Kövari, Enikö</creatorcontrib><creatorcontrib>Bouras, Constantin</creatorcontrib><creatorcontrib>Karavatos, Athanasios</creatorcontrib><title>Neurofibrillary tangles in elderly patients with late onset schizophrenia</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The objective of the present study was to examine whether neurofibrillary tangles densities are increased in elderly patients with late-onset schizophrenia (LOS). A neuropathological examination was performed in 32 consecutive autopsy brain specimens of ten patients with early-onset schizophrenia (EOS; onset of symptoms before the age of 40 years), eight patients with LOS (onset of symptoms after the age of 40 years) and 14 age-matched controls with no known neuropsychiatric disorder. Neurofibrillary tangle densities observed in the CA1 field of the hippocampus, the enthorhinal cortex, and the inferior temporal cortex in patients with LOS, EOS, and controls were not significantly different. All patients with EOS or LOS had Braak stages of III or less, which may correspond to normal aging. Thus, patients with schizophrenia, regardless of the age of onset of their symptoms, are no more prone to the development of Alzheimer's disease than the general population.</description><subject>Adult and adolescent clinical studies</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - pathology</subject><subject>Disease Progression</subject><subject>Hippocampus - pathology</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Late-onset schizophrenia</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neocortex - pathology</subject><subject>Neocortex - physiopathology</subject><subject>Neurofibrillary tangles</subject><subject>Neurofibrillary Tangles - pathology</subject><subject>Neurons - pathology</subject><subject>Neuropathology</subject><subject>Plaque, Amyloid - pathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenia - epidemiology</subject><subject>Schizophrenia - pathology</subject><subject>Temporal Lobe - pathology</subject><subject>Temporal Lobe - physiopathology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMGO0zAQhi0Eot3CI4ByAS2HwNiJY_uEULULlSo4AGfLccbUKE2K7YCWp8dtI3rsaaTR9_8z-gh5QeEtBdq8-woV1GWlargF9gaASlXSR2RJpWClUII9Jsv_yILcxPgTADjl9VOyoFRJWVVqSTafcQqj823wfW_CQ5HM8KPHWPihwL7D0D8UB5M8DikWf3zaFb1JWIxDxFREu_N_x8Mu4ODNM_LEmT7i83muyPf7u2_rT-X2y8fN-sO2tDVjqURGqeSuEbSplWqlQofSMWtbA9IqVwvhhAFnhAQuaZO3vBZd1TEuO2Z4tSKvz72HMP6aMCa999Fi_n7AcYo6F3NgXF0FsykBsj6C_AzaMMYY0OlD8PssQ1PQR9n6JFsfTWpg-iRb05x7OR-Y2j12l9RsNwOvZsBEa3oXzGB9vHBVU4mGQubenznM3n57DDrabNxi5wPapLvRX3nlH0hjm2c</recordid><startdate>20020517</startdate><enddate>20020517</enddate><creator>Bozikas, Vasilis P</creator><creator>Kövari, Enikö</creator><creator>Bouras, Constantin</creator><creator>Karavatos, Athanasios</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20020517</creationdate><title>Neurofibrillary tangles in elderly patients with late onset schizophrenia</title><author>Bozikas, Vasilis P ; Kövari, Enikö ; Bouras, Constantin ; Karavatos, Athanasios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-e21185f6716499b89efe8f2ccba08c9f477f7a0fa7805816a08547d3d258d2a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - complications</topic><topic>Alzheimer Disease - epidemiology</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - pathology</topic><topic>Disease Progression</topic><topic>Hippocampus - pathology</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Late-onset schizophrenia</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neocortex - pathology</topic><topic>Neocortex - physiopathology</topic><topic>Neurofibrillary tangles</topic><topic>Neurofibrillary Tangles - pathology</topic><topic>Neurons - pathology</topic><topic>Neuropathology</topic><topic>Plaque, Amyloid - pathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenia - epidemiology</topic><topic>Schizophrenia - pathology</topic><topic>Temporal Lobe - pathology</topic><topic>Temporal Lobe - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bozikas, Vasilis P</creatorcontrib><creatorcontrib>Kövari, Enikö</creatorcontrib><creatorcontrib>Bouras, Constantin</creatorcontrib><creatorcontrib>Karavatos, Athanasios</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bozikas, Vasilis P</au><au>Kövari, Enikö</au><au>Bouras, Constantin</au><au>Karavatos, Athanasios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurofibrillary tangles in elderly patients with late onset schizophrenia</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2002-05-17</date><risdate>2002</risdate><volume>324</volume><issue>2</issue><spage>109</spage><epage>112</epage><pages>109-112</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The objective of the present study was to examine whether neurofibrillary tangles densities are increased in elderly patients with late-onset schizophrenia (LOS). A neuropathological examination was performed in 32 consecutive autopsy brain specimens of ten patients with early-onset schizophrenia (EOS; onset of symptoms before the age of 40 years), eight patients with LOS (onset of symptoms after the age of 40 years) and 14 age-matched controls with no known neuropsychiatric disorder. Neurofibrillary tangle densities observed in the CA1 field of the hippocampus, the enthorhinal cortex, and the inferior temporal cortex in patients with LOS, EOS, and controls were not significantly different. All patients with EOS or LOS had Braak stages of III or less, which may correspond to normal aging. Thus, patients with schizophrenia, regardless of the age of onset of their symptoms, are no more prone to the development of Alzheimer's disease than the general population.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11988339</pmid><doi>10.1016/S0304-3940(02)00189-1</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Age of Onset Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - epidemiology Alzheimer Disease - pathology Alzheimer's disease Biological and medical sciences Cognition Disorders - epidemiology Cognition Disorders - etiology Cognition Disorders - pathology Disease Progression Hippocampus - pathology Hippocampus - physiopathology Humans Late-onset schizophrenia Medical sciences Middle Aged Neocortex - pathology Neocortex - physiopathology Neurofibrillary tangles Neurofibrillary Tangles - pathology Neurons - pathology Neuropathology Plaque, Amyloid - pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - complications Schizophrenia - epidemiology Schizophrenia - pathology Temporal Lobe - pathology Temporal Lobe - physiopathology |
| title | Neurofibrillary tangles in elderly patients with late onset schizophrenia |
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