Patients with multiple sclerosis and risk of type 1 diabetes mellitus in Sardinia, Italy: a cohort study
Individuals from Sardinia, Italy, are at high risk of developing multiple sclerosis and type 1 diabetes mellitus. We attempted to assess the prevalence in this region of type 1 diabetes mellitus in individuals with multiple sclerosis, and to ascertain disease risk factors. We did a cohort study to a...
Gespeichert in:
| Veröffentlicht in: | The Lancet (British edition) 2002-04, Vol.359 (9316), p.1461-1465 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1465 |
|---|---|
| container_issue | 9316 |
| container_start_page | 1461 |
| container_title | The Lancet (British edition) |
| container_volume | 359 |
| creator | Marrosu, Maria Giovanna Cocco, Eleonora Lai, Marina Spinicci, Gabriella Pischedda, Maria Paola Contu, Paolo |
| description | Individuals from Sardinia, Italy, are at high risk of developing multiple sclerosis and type 1 diabetes mellitus. We attempted to assess the prevalence in this region of type 1 diabetes mellitus in individuals with multiple sclerosis, and to ascertain disease risk factors.
We did a cohort study to assess prevalence of type 1 diabetes in 1090 people with multiple sclerosis, and in their parents (n=2180) and siblings (n=3300), all born and living in Sardinia. All participants were patients at the multiple sclerosis clinic in Cagliari, and were judged representative of the total Sardinian outpatients and inpatients. We asked patients whether their parents or siblings had multiple sclerosis or diabetes, confirming replies by examining clinical records. We identified risk factors for diabetes with univariate and multivariate logistic regression analyses.
Diabetes prevalence in people with multiple sclerosis was, respectively, about three-fold and five-fold that in their healthy siblings (p=0·001) and in the general population (p |
| doi_str_mv | 10.1016/S0140-6736(02)08431-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71649483</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0140673602084313</els_id><sourcerecordid>71649483</sourcerecordid><originalsourceid>FETCH-LOGICAL-c446t-8484fdf8bbc46f920cc33086f0464ad619ff91423256448f5e76620e0f2069b43</originalsourceid><addsrcrecordid>eNqFkVmLFDEYRYMoTtv6E5SgKAqWZvkqlfgiMrgMDCiMgm8hlYXOWEtPklL635uebhwQxKe8nNzc3IPQQ0peUULF6wtCgTSi4-I5YS-IBE4bfgutKHTQtNB9v41Wf5ATdC_nS0IICNLeRSeUKikZ8BXafDEl-qlk_CuWDR6XocTt4HG2g09zjhmbyeEU8w88B1x2W48pdtH0vviMRz8MsSwZxwlfmOTiFM1LfFbMsHuDDbbzZk4F57K43X10J5gh-wfHc42-fXj_9fRTc_7549npu_PGAojSSJAQXJB9b0EExYi1nBMpQq0OxgmqQlAUGGetAJCh9Z0QjHgSGBGqB75Gzw652zRfLT4XPcZsa08z-XnJuqMCFEhewSd_gZfzkqbaTdcoWR-ghFXq8b8oqlTlVN13jdoDZOtkOfmgtymOJu00JXpvS1_b0nsVmjB9bUvvKzw6hi_96N3NraOeCjw9AiZbM4RkJhvzDccFV4rtP_32wPm67M_ok862WrXexeRt0W6O_6nyG6a7rtw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199068967</pqid></control><display><type>article</type><title>Patients with multiple sclerosis and risk of type 1 diabetes mellitus in Sardinia, Italy: a cohort study</title><source>MEDLINE</source><source>Business Source Complete</source><source>ScienceDirect Journals (5 years ago - present)</source><source>ProQuest Central UK/Ireland</source><creator>Marrosu, Maria Giovanna ; Cocco, Eleonora ; Lai, Marina ; Spinicci, Gabriella ; Pischedda, Maria Paola ; Contu, Paolo</creator><creatorcontrib>Marrosu, Maria Giovanna ; Cocco, Eleonora ; Lai, Marina ; Spinicci, Gabriella ; Pischedda, Maria Paola ; Contu, Paolo</creatorcontrib><description>Individuals from Sardinia, Italy, are at high risk of developing multiple sclerosis and type 1 diabetes mellitus. We attempted to assess the prevalence in this region of type 1 diabetes mellitus in individuals with multiple sclerosis, and to ascertain disease risk factors.
We did a cohort study to assess prevalence of type 1 diabetes in 1090 people with multiple sclerosis, and in their parents (n=2180) and siblings (n=3300), all born and living in Sardinia. All participants were patients at the multiple sclerosis clinic in Cagliari, and were judged representative of the total Sardinian outpatients and inpatients. We asked patients whether their parents or siblings had multiple sclerosis or diabetes, confirming replies by examining clinical records. We identified risk factors for diabetes with univariate and multivariate logistic regression analyses.
Diabetes prevalence in people with multiple sclerosis was, respectively, about three-fold and five-fold that in their healthy siblings (p=0·001) and in the general population (p<0·0001). Presence of other relatives with multiple sclerosis conferred increased risk of type 1 diabetes to healthy siblings of individuals with multiple sclerosis (odds ratio=3·41, p=0·0019). Diabetes risk was six-fold higher in patients with relatives having multiple sclerosis than in healthy siblings of multiple sclerosis patients without other relatives with the disease (p=0·0001).
In Sardinian families with genetic inheritance of multiple sclerosis type 1 diabetes is prevalent, both in multiple sclerosis patients and in healthy siblings. This finding indicates that common genes contribute to susceptibility to both diseases in this population.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(02)08431-3</identifier><identifier>PMID: 11988243</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Autoimmune diseases ; Biological and medical sciences ; Child ; Cohort analysis ; Cohort Studies ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetes Mellitus, Type 1 - genetics ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Families & family life ; Family Health ; Female ; Grandparents ; Health risks ; Heredity ; Humans ; Italy - epidemiology ; Male ; Medical research ; Medical sciences ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis - complications ; Multiple Sclerosis - epidemiology ; Multiple Sclerosis - genetics ; Multivariate analysis ; Parents ; Pathogenesis ; Patients ; Population ; Prevalence ; Regression analysis ; Risk analysis ; Risk Factors ; Siblings ; Statistical analysis ; Womens health</subject><ispartof>The Lancet (British edition), 2002-04, Vol.359 (9316), p.1461-1465</ispartof><rights>2002 Elsevier Ltd</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Apr 27, 2002</rights><rights>Copyright Elsevier Limited Apr 27, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-8484fdf8bbc46f920cc33086f0464ad619ff91423256448f5e76620e0f2069b43</citedby><cites>FETCH-LOGICAL-c446t-8484fdf8bbc46f920cc33086f0464ad619ff91423256448f5e76620e0f2069b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199068967?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13639924$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11988243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marrosu, Maria Giovanna</creatorcontrib><creatorcontrib>Cocco, Eleonora</creatorcontrib><creatorcontrib>Lai, Marina</creatorcontrib><creatorcontrib>Spinicci, Gabriella</creatorcontrib><creatorcontrib>Pischedda, Maria Paola</creatorcontrib><creatorcontrib>Contu, Paolo</creatorcontrib><title>Patients with multiple sclerosis and risk of type 1 diabetes mellitus in Sardinia, Italy: a cohort study</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Individuals from Sardinia, Italy, are at high risk of developing multiple sclerosis and type 1 diabetes mellitus. We attempted to assess the prevalence in this region of type 1 diabetes mellitus in individuals with multiple sclerosis, and to ascertain disease risk factors.
We did a cohort study to assess prevalence of type 1 diabetes in 1090 people with multiple sclerosis, and in their parents (n=2180) and siblings (n=3300), all born and living in Sardinia. All participants were patients at the multiple sclerosis clinic in Cagliari, and were judged representative of the total Sardinian outpatients and inpatients. We asked patients whether their parents or siblings had multiple sclerosis or diabetes, confirming replies by examining clinical records. We identified risk factors for diabetes with univariate and multivariate logistic regression analyses.
Diabetes prevalence in people with multiple sclerosis was, respectively, about three-fold and five-fold that in their healthy siblings (p=0·001) and in the general population (p<0·0001). Presence of other relatives with multiple sclerosis conferred increased risk of type 1 diabetes to healthy siblings of individuals with multiple sclerosis (odds ratio=3·41, p=0·0019). Diabetes risk was six-fold higher in patients with relatives having multiple sclerosis than in healthy siblings of multiple sclerosis patients without other relatives with the disease (p=0·0001).
In Sardinian families with genetic inheritance of multiple sclerosis type 1 diabetes is prevalent, both in multiple sclerosis patients and in healthy siblings. This finding indicates that common genes contribute to susceptibility to both diseases in this population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Autoimmune diseases</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>Diabetes Mellitus, Type 1 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Families & family life</subject><subject>Family Health</subject><subject>Female</subject><subject>Grandparents</subject><subject>Health risks</subject><subject>Heredity</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - complications</subject><subject>Multiple Sclerosis - epidemiology</subject><subject>Multiple Sclerosis - genetics</subject><subject>Multivariate analysis</subject><subject>Parents</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Population</subject><subject>Prevalence</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Siblings</subject><subject>Statistical analysis</subject><subject>Womens health</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkVmLFDEYRYMoTtv6E5SgKAqWZvkqlfgiMrgMDCiMgm8hlYXOWEtPklL635uebhwQxKe8nNzc3IPQQ0peUULF6wtCgTSi4-I5YS-IBE4bfgutKHTQtNB9v41Wf5ATdC_nS0IICNLeRSeUKikZ8BXafDEl-qlk_CuWDR6XocTt4HG2g09zjhmbyeEU8w88B1x2W48pdtH0vviMRz8MsSwZxwlfmOTiFM1LfFbMsHuDDbbzZk4F57K43X10J5gh-wfHc42-fXj_9fRTc_7549npu_PGAojSSJAQXJB9b0EExYi1nBMpQq0OxgmqQlAUGGetAJCh9Z0QjHgSGBGqB75Gzw652zRfLT4XPcZsa08z-XnJuqMCFEhewSd_gZfzkqbaTdcoWR-ghFXq8b8oqlTlVN13jdoDZOtkOfmgtymOJu00JXpvS1_b0nsVmjB9bUvvKzw6hi_96N3NraOeCjw9AiZbM4RkJhvzDccFV4rtP_32wPm67M_ok862WrXexeRt0W6O_6nyG6a7rtw</recordid><startdate>20020427</startdate><enddate>20020427</enddate><creator>Marrosu, Maria Giovanna</creator><creator>Cocco, Eleonora</creator><creator>Lai, Marina</creator><creator>Spinicci, Gabriella</creator><creator>Pischedda, Maria Paola</creator><creator>Contu, Paolo</creator><general>Elsevier Ltd</general><general>Lancet</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20020427</creationdate><title>Patients with multiple sclerosis and risk of type 1 diabetes mellitus in Sardinia, Italy: a cohort study</title><author>Marrosu, Maria Giovanna ; Cocco, Eleonora ; Lai, Marina ; Spinicci, Gabriella ; Pischedda, Maria Paola ; Contu, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-8484fdf8bbc46f920cc33086f0464ad619ff91423256448f5e76620e0f2069b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Autoimmune diseases</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - epidemiology</topic><topic>Diabetes Mellitus, Type 1 - genetics</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Families & family life</topic><topic>Family Health</topic><topic>Female</topic><topic>Grandparents</topic><topic>Health risks</topic><topic>Heredity</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - complications</topic><topic>Multiple Sclerosis - epidemiology</topic><topic>Multiple Sclerosis - genetics</topic><topic>Multivariate analysis</topic><topic>Parents</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Population</topic><topic>Prevalence</topic><topic>Regression analysis</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Siblings</topic><topic>Statistical analysis</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marrosu, Maria Giovanna</creatorcontrib><creatorcontrib>Cocco, Eleonora</creatorcontrib><creatorcontrib>Lai, Marina</creatorcontrib><creatorcontrib>Spinicci, Gabriella</creatorcontrib><creatorcontrib>Pischedda, Maria Paola</creatorcontrib><creatorcontrib>Contu, Paolo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>News PRO</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Global News & ABI/Inform Professional</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Lancet Titles</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Newsstand Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marrosu, Maria Giovanna</au><au>Cocco, Eleonora</au><au>Lai, Marina</au><au>Spinicci, Gabriella</au><au>Pischedda, Maria Paola</au><au>Contu, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patients with multiple sclerosis and risk of type 1 diabetes mellitus in Sardinia, Italy: a cohort study</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2002-04-27</date><risdate>2002</risdate><volume>359</volume><issue>9316</issue><spage>1461</spage><epage>1465</epage><pages>1461-1465</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Individuals from Sardinia, Italy, are at high risk of developing multiple sclerosis and type 1 diabetes mellitus. We attempted to assess the prevalence in this region of type 1 diabetes mellitus in individuals with multiple sclerosis, and to ascertain disease risk factors.
We did a cohort study to assess prevalence of type 1 diabetes in 1090 people with multiple sclerosis, and in their parents (n=2180) and siblings (n=3300), all born and living in Sardinia. All participants were patients at the multiple sclerosis clinic in Cagliari, and were judged representative of the total Sardinian outpatients and inpatients. We asked patients whether their parents or siblings had multiple sclerosis or diabetes, confirming replies by examining clinical records. We identified risk factors for diabetes with univariate and multivariate logistic regression analyses.
Diabetes prevalence in people with multiple sclerosis was, respectively, about three-fold and five-fold that in their healthy siblings (p=0·001) and in the general population (p<0·0001). Presence of other relatives with multiple sclerosis conferred increased risk of type 1 diabetes to healthy siblings of individuals with multiple sclerosis (odds ratio=3·41, p=0·0019). Diabetes risk was six-fold higher in patients with relatives having multiple sclerosis than in healthy siblings of multiple sclerosis patients without other relatives with the disease (p=0·0001).
In Sardinian families with genetic inheritance of multiple sclerosis type 1 diabetes is prevalent, both in multiple sclerosis patients and in healthy siblings. This finding indicates that common genes contribute to susceptibility to both diseases in this population.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>11988243</pmid><doi>10.1016/S0140-6736(02)08431-3</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 2002-04, Vol.359 (9316), p.1461-1465 |
| issn | 0140-6736 1474-547X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71649483 |
| source | MEDLINE; Business Source Complete; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | Adolescent Adult Aged Autoimmune diseases Biological and medical sciences Child Cohort analysis Cohort Studies Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Families & family life Family Health Female Grandparents Health risks Heredity Humans Italy - epidemiology Male Medical research Medical sciences Middle Aged Multiple sclerosis Multiple Sclerosis - complications Multiple Sclerosis - epidemiology Multiple Sclerosis - genetics Multivariate analysis Parents Pathogenesis Patients Population Prevalence Regression analysis Risk analysis Risk Factors Siblings Statistical analysis Womens health |
| title | Patients with multiple sclerosis and risk of type 1 diabetes mellitus in Sardinia, Italy: a cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T05%3A36%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Patients%20with%20multiple%20sclerosis%20and%20risk%20of%20type%201%20diabetes%20mellitus%20in%20Sardinia,%20Italy:%20a%20cohort%20study&rft.jtitle=The%20Lancet%20(British%20edition)&rft.au=Marrosu,%20Maria%20Giovanna&rft.date=2002-04-27&rft.volume=359&rft.issue=9316&rft.spage=1461&rft.epage=1465&rft.pages=1461-1465&rft.issn=0140-6736&rft.eissn=1474-547X&rft.coden=LANCAO&rft_id=info:doi/10.1016/S0140-6736(02)08431-3&rft_dat=%3Cproquest_cross%3E71649483%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=199068967&rft_id=info:pmid/11988243&rft_els_id=S0140673602084313&rfr_iscdi=true |