Linking miRNA Regulation to BCR-ABL Expression: The Next Dimension

The introduction of tyrosine kinase inhibitors in the treatment of BCR-ABL1-rearranged malignancies has revolutionized therapy, but the prognosis for acute leukemias remains suboptimal. In this issue of Cancer Cell, Bueno et al. (2008) add a new dimension to the regulation of ABL1 expression. The au...

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Veröffentlicht in:Cancer cell 2008-06, Vol.13 (6), p.467-469
Hauptverfasser: Faber, Jörg, Gregory, Richard I., Armstrong, Scott A.
Format: Artikel
Sprache:eng
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Zusammenfassung:The introduction of tyrosine kinase inhibitors in the treatment of BCR-ABL1-rearranged malignancies has revolutionized therapy, but the prognosis for acute leukemias remains suboptimal. In this issue of Cancer Cell, Bueno et al. (2008) add a new dimension to the regulation of ABL1 expression. The authors demonstrate that ABL1 is a direct target of miR-203, miR-203 is silenced by genetic and epigenetic mechanisms in hematopoietic malignancies expressing either ABL1 or BCR-ABL1, and restoration of miR-203 expression reduces ABL1 and BCR-ABL1 levels and inhibits cell proliferation. These findings may have broad implications for mechanisms underlying malignant transformation in hematopoietic and other malignancies.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2008.05.013