Controlled release of donepezil intercalated in smectite clays
The inorganic–organic hybrid for a drug delivery system was successfully realized by intercalating donepezil molecules into smectite clays (laponite XLG, saponite, and montmorillonite). According to the powder XRD patterns, TG profiles, and FT-IR spectra, it was confirmed that donepezil molecules we...
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| Veröffentlicht in: | International journal of pharmaceutics 2008-07, Vol.359 (1), p.198-204 |
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| container_title | International journal of pharmaceutics |
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| creator | Park, Jin Kuen Choy, Young Bin Oh, Jae-Min Kim, Ju Young Hwang, Seong-Ju Choy, Jin-Ho |
| description | The inorganic–organic hybrid for a drug delivery system was successfully realized by intercalating donepezil molecules into smectite clays (laponite XLG, saponite, and montmorillonite). According to the powder XRD patterns, TG profiles, and FT-IR spectra, it was confirmed that donepezil molecules were well stabilized in the interlayer space of clay via mono or double layer stacking. The adsorption amount and molecular structure of donepezil appeared to depend on the cation exchange capacity of the clay, which in turn, tailored the drug release patterns. Especially in the presence of a bulky cationic polymer (Eudragit
® E-100) in the release media, the release rate was found to be improved due to its effective replacement with intercalated donepezil molecules. Therefore, to formulate a complete drug delivery system, the hybrids were coated with Eudragit
® E-100 using a spray dryer, which also showed great enhancement in the release rate during a short period of time (180
min). |
| doi_str_mv | 10.1016/j.ijpharm.2008.04.012 |
| format | Article |
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® E-100) in the release media, the release rate was found to be improved due to its effective replacement with intercalated donepezil molecules. Therefore, to formulate a complete drug delivery system, the hybrids were coated with Eudragit
® E-100 using a spray dryer, which also showed great enhancement in the release rate during a short period of time (180
min).</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2008.04.012</identifier><identifier>PMID: 18502063</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acrylates - chemistry ; Adsorption ; Aluminum Silicates - chemistry ; Bentonite - chemistry ; Biological and medical sciences ; Cholinesterase Inhibitors - chemistry ; Controlled release ; Delayed-Action Preparations ; Donepezil ; Drug Carriers - chemistry ; Drug delivery system ; Drug Delivery Systems ; General pharmacology ; Hybrid ; Indans - chemistry ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Piperidines - chemistry ; Polymers - chemistry ; Powder Diffraction ; Silicates - chemistry ; Smectite clay ; Spectroscopy, Fourier Transform Infrared ; Thermogravimetry ; Time Factors</subject><ispartof>International journal of pharmaceutics, 2008-07, Vol.359 (1), p.198-204</ispartof><rights>2008 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-ecff66cc22bdadf7c6d7a05339500e5f54fa7348d76fa9846d5878839ff178c23</citedby><cites>FETCH-LOGICAL-c393t-ecff66cc22bdadf7c6d7a05339500e5f54fa7348d76fa9846d5878839ff178c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2008.04.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20466702$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18502063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Jin Kuen</creatorcontrib><creatorcontrib>Choy, Young Bin</creatorcontrib><creatorcontrib>Oh, Jae-Min</creatorcontrib><creatorcontrib>Kim, Ju Young</creatorcontrib><creatorcontrib>Hwang, Seong-Ju</creatorcontrib><creatorcontrib>Choy, Jin-Ho</creatorcontrib><title>Controlled release of donepezil intercalated in smectite clays</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>The inorganic–organic hybrid for a drug delivery system was successfully realized by intercalating donepezil molecules into smectite clays (laponite XLG, saponite, and montmorillonite). According to the powder XRD patterns, TG profiles, and FT-IR spectra, it was confirmed that donepezil molecules were well stabilized in the interlayer space of clay via mono or double layer stacking. The adsorption amount and molecular structure of donepezil appeared to depend on the cation exchange capacity of the clay, which in turn, tailored the drug release patterns. Especially in the presence of a bulky cationic polymer (Eudragit
® E-100) in the release media, the release rate was found to be improved due to its effective replacement with intercalated donepezil molecules. Therefore, to formulate a complete drug delivery system, the hybrids were coated with Eudragit
® E-100 using a spray dryer, which also showed great enhancement in the release rate during a short period of time (180
min).</description><subject>Acrylates - chemistry</subject><subject>Adsorption</subject><subject>Aluminum Silicates - chemistry</subject><subject>Bentonite - chemistry</subject><subject>Biological and medical sciences</subject><subject>Cholinesterase Inhibitors - chemistry</subject><subject>Controlled release</subject><subject>Delayed-Action Preparations</subject><subject>Donepezil</subject><subject>Drug Carriers - chemistry</subject><subject>Drug delivery system</subject><subject>Drug Delivery Systems</subject><subject>General pharmacology</subject><subject>Hybrid</subject><subject>Indans - chemistry</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperidines - chemistry</subject><subject>Polymers - chemistry</subject><subject>Powder Diffraction</subject><subject>Silicates - chemistry</subject><subject>Smectite clay</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Thermogravimetry</subject><subject>Time Factors</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1LxDAQgOEgiq4fP0HpRW-tk6ZN0osii1-w4EXPIZtMMEvarklX0F9vly169JTLOzPhIeScQkGB8utV4Vfrdx3bogSQBVQF0HKPzKgULGeV4PtkBkzIvKaCHZHjlFYAwEvKDskRlTWUwNmM3Mz7boh9CGiziAF1wqx3me07XOO3D5nvBoxGBz2Mhe-y1KIZ_ICZCfornZIDp0PCs-k9IW8P96_zp3zx8vg8v1vkhjVsyNE4x7kxZbm02jphuBUaasaaGgBrV1dOC1ZJK7jTjay4raWQkjXOUSFNyU7I1W7vOvYfG0yDan0yGILusN8kJSivpIBmDOtdaGKfUkSn1tG3On4pCmoLp1ZqglNbOAWVGuHGuYvpwGbZov2bmqTG4HIKdBo5XNSd8em3K6HiXMB20e2uw5Hj02NUyXjsDFofRzlle__PV34Aa6SOuQ</recordid><startdate>20080709</startdate><enddate>20080709</enddate><creator>Park, Jin Kuen</creator><creator>Choy, Young Bin</creator><creator>Oh, Jae-Min</creator><creator>Kim, Ju Young</creator><creator>Hwang, Seong-Ju</creator><creator>Choy, Jin-Ho</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080709</creationdate><title>Controlled release of donepezil intercalated in smectite clays</title><author>Park, Jin Kuen ; Choy, Young Bin ; Oh, Jae-Min ; Kim, Ju Young ; Hwang, Seong-Ju ; Choy, Jin-Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-ecff66cc22bdadf7c6d7a05339500e5f54fa7348d76fa9846d5878839ff178c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acrylates - chemistry</topic><topic>Adsorption</topic><topic>Aluminum Silicates - chemistry</topic><topic>Bentonite - chemistry</topic><topic>Biological and medical sciences</topic><topic>Cholinesterase Inhibitors - chemistry</topic><topic>Controlled release</topic><topic>Delayed-Action Preparations</topic><topic>Donepezil</topic><topic>Drug Carriers - chemistry</topic><topic>Drug delivery system</topic><topic>Drug Delivery Systems</topic><topic>General pharmacology</topic><topic>Hybrid</topic><topic>Indans - chemistry</topic><topic>Medical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Piperidines - chemistry</topic><topic>Polymers - chemistry</topic><topic>Powder Diffraction</topic><topic>Silicates - chemistry</topic><topic>Smectite clay</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Thermogravimetry</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Jin Kuen</creatorcontrib><creatorcontrib>Choy, Young Bin</creatorcontrib><creatorcontrib>Oh, Jae-Min</creatorcontrib><creatorcontrib>Kim, Ju Young</creatorcontrib><creatorcontrib>Hwang, Seong-Ju</creatorcontrib><creatorcontrib>Choy, Jin-Ho</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Jin Kuen</au><au>Choy, Young Bin</au><au>Oh, Jae-Min</au><au>Kim, Ju Young</au><au>Hwang, Seong-Ju</au><au>Choy, Jin-Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlled release of donepezil intercalated in smectite clays</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2008-07-09</date><risdate>2008</risdate><volume>359</volume><issue>1</issue><spage>198</spage><epage>204</epage><pages>198-204</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>The inorganic–organic hybrid for a drug delivery system was successfully realized by intercalating donepezil molecules into smectite clays (laponite XLG, saponite, and montmorillonite). According to the powder XRD patterns, TG profiles, and FT-IR spectra, it was confirmed that donepezil molecules were well stabilized in the interlayer space of clay via mono or double layer stacking. The adsorption amount and molecular structure of donepezil appeared to depend on the cation exchange capacity of the clay, which in turn, tailored the drug release patterns. Especially in the presence of a bulky cationic polymer (Eudragit
® E-100) in the release media, the release rate was found to be improved due to its effective replacement with intercalated donepezil molecules. Therefore, to formulate a complete drug delivery system, the hybrids were coated with Eudragit
® E-100 using a spray dryer, which also showed great enhancement in the release rate during a short period of time (180
min).</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18502063</pmid><doi>10.1016/j.ijpharm.2008.04.012</doi><tpages>7</tpages></addata></record> |
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| subjects | Acrylates - chemistry Adsorption Aluminum Silicates - chemistry Bentonite - chemistry Biological and medical sciences Cholinesterase Inhibitors - chemistry Controlled release Delayed-Action Preparations Donepezil Drug Carriers - chemistry Drug delivery system Drug Delivery Systems General pharmacology Hybrid Indans - chemistry Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Piperidines - chemistry Polymers - chemistry Powder Diffraction Silicates - chemistry Smectite clay Spectroscopy, Fourier Transform Infrared Thermogravimetry Time Factors |
| title | Controlled release of donepezil intercalated in smectite clays |
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