Fluorescence detection of plant extracts that affect neuronal voltage-gated Ca2+ channels

Structurally novel compounds able to block voltage-gated Ca2+ channels (VGCCs) are currently being sought for the development of new drugs directed at neurological disorders. Fluorescence techniques have recently been developed to facilitate the analysis of VGCC blockers in a multi-well format. By u...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2002-05, Vol.15 (4), p.321-330
Hauptverfasser:	ROGERS, K. L, FONG, W. F, REDBURN, J, GRIFFITHS, L. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Aniline Compounds Australia Biological and medical sciences Buffers Calcium Channels - drug effects Fluorescent Dyes General pharmacology Humans Ion Channel Gating - drug effects Ion Channel Gating - physiology Medical sciences Neurons - drug effects Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Spectrometry, Fluorescence Tumor Cells, Cultured Xanthenes
Online-Zugang:	Volltext
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