Prevention of Cellular ROS Damage by Isovitexin and Related Flavonoids
Abstract The antioxidant properties of isovitexin and related flavonoids were studied. Isovitexin inhibited xanthine oxidase with an IC 50 value of = 15.2 μM. The flavonoid analogues, apigenin, kaempferol, quercetin, myricetin, and genistein also inhibited xanthine oxidase with IC 50 values of 0.58,...
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| Veröffentlicht in: | Planta medica 2002-04, Vol.68 (4), p.365-367 |
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| creator | Lin, Chun-Mao Chen, Chien-Tsu Lee, Hsiao-Hui Lin, Jen-Kun |
| description | Abstract
The antioxidant properties of isovitexin and related flavonoids were studied. Isovitexin inhibited xanthine oxidase with an IC
50
value of = 15.2 μM. The flavonoid analogues, apigenin, kaempferol, quercetin, myricetin, and genistein also inhibited xanthine oxidase with IC
50
values of 0.58, 2.18, 1.09, 9.90, and 4.83 μM, respectively. Isovitexin protected DNA from the Fenton reaction-induced breakage in a dose-dependent manner with an IC
50
value of 9.52 μM. Isovitexin also protected HL-60 cells from the ROS damage induced by the xanthine/xanthine oxidase reaction. Isovitexin exhibited the lowest cytotoxicity toward HL-60 cells (LD
50
>400 μM) compared to the other flavonoids examined. In addition, excess hydrogen peroxide induced by cadmium in A2780 ovarian cells was significantly suppressed by isovitexin. These results suggest that isovitexin in rice may protect cells from oxidative stress. |
| doi_str_mv | 10.1055/s-2002-26753 |
| format | Article |
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The antioxidant properties of isovitexin and related flavonoids were studied. Isovitexin inhibited xanthine oxidase with an IC
50
value of = 15.2 μM. The flavonoid analogues, apigenin, kaempferol, quercetin, myricetin, and genistein also inhibited xanthine oxidase with IC
50
values of 0.58, 2.18, 1.09, 9.90, and 4.83 μM, respectively. Isovitexin protected DNA from the Fenton reaction-induced breakage in a dose-dependent manner with an IC
50
value of 9.52 μM. Isovitexin also protected HL-60 cells from the ROS damage induced by the xanthine/xanthine oxidase reaction. Isovitexin exhibited the lowest cytotoxicity toward HL-60 cells (LD
50
>400 μM) compared to the other flavonoids examined. In addition, excess hydrogen peroxide induced by cadmium in A2780 ovarian cells was significantly suppressed by isovitexin. These results suggest that isovitexin in rice may protect cells from oxidative stress.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2002-26753</identifier><identifier>PMID: 11988866</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Apigenin ; Biological and medical sciences ; Cadmium - pharmacology ; DNA Damage - drug effects ; Flavonoids - chemistry ; Flavonoids - pharmacology ; General pharmacology ; HL-60 Cells ; Humans ; Hydrogen Peroxide - metabolism ; Letter ; Medical sciences ; Oryza ; Oxidative Stress - drug effects ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Reactive Oxygen Species - metabolism ; Xanthine - metabolism ; Xanthine - pharmacology ; Xanthine Oxidase - metabolism ; Xanthine Oxidase - pharmacology</subject><ispartof>Planta medica, 2002-04, Vol.68 (4), p.365-367</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-7f182fbd98c09f1ed90e5cb26fabc01b607f5d3732a569aac8a9aceb30023cfe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2002-26753.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2002-26753$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3004,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13647968$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11988866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Chun-Mao</creatorcontrib><creatorcontrib>Chen, Chien-Tsu</creatorcontrib><creatorcontrib>Lee, Hsiao-Hui</creatorcontrib><creatorcontrib>Lin, Jen-Kun</creatorcontrib><title>Prevention of Cellular ROS Damage by Isovitexin and Related Flavonoids</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
The antioxidant properties of isovitexin and related flavonoids were studied. Isovitexin inhibited xanthine oxidase with an IC
50
value of = 15.2 μM. The flavonoid analogues, apigenin, kaempferol, quercetin, myricetin, and genistein also inhibited xanthine oxidase with IC
50
values of 0.58, 2.18, 1.09, 9.90, and 4.83 μM, respectively. Isovitexin protected DNA from the Fenton reaction-induced breakage in a dose-dependent manner with an IC
50
value of 9.52 μM. Isovitexin also protected HL-60 cells from the ROS damage induced by the xanthine/xanthine oxidase reaction. Isovitexin exhibited the lowest cytotoxicity toward HL-60 cells (LD
50
>400 μM) compared to the other flavonoids examined. In addition, excess hydrogen peroxide induced by cadmium in A2780 ovarian cells was significantly suppressed by isovitexin. These results suggest that isovitexin in rice may protect cells from oxidative stress.</description><subject>Apigenin</subject><subject>Biological and medical sciences</subject><subject>Cadmium - pharmacology</subject><subject>DNA Damage - drug effects</subject><subject>Flavonoids - chemistry</subject><subject>Flavonoids - pharmacology</subject><subject>General pharmacology</subject><subject>HL-60 Cells</subject><subject>Humans</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Letter</subject><subject>Medical sciences</subject><subject>Oryza</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Xanthine - metabolism</subject><subject>Xanthine - pharmacology</subject><subject>Xanthine Oxidase - metabolism</subject><subject>Xanthine Oxidase - pharmacology</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0M9P2zAUwHELgaDrduOMfGGXLePZzi8fUbduSEhF3Xa2XpxnSJXEYCfV-O-X0kq9cPLlo_eev4xdCvgmIMtuYiIBZCLzIlMnbCZSpROQUpyyGYCSCehUXbAPMW4ARKoBztmFELosyzyfseVDoC31Q-N77h1fUNuOLQa-Xv3m37HDR-LVK7-LftsM9K_pOfY1X1OLA9V82eLW976p40d25rCN9Onwztnf5Y8_i1_J_ern3eL2PrEqU0NSOFFKV9W6tKCdoFoDZbaSucPKgqhyKFxWq0JJzHKNaEvUaKlS0w-VdaTm7PN-7nPwLyPFwXRNtNPR2JMfoylEnhZayQl-3UMbfIyBnHkOTYfh1Qgwu24mml0389Zt4leHuWPVUX3Eh1ATuD4AjBZbF7C3TTw6tdubl5P7snfDU0MdmY0fQz8VeX_tf2iogpY</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Lin, Chun-Mao</creator><creator>Chen, Chien-Tsu</creator><creator>Lee, Hsiao-Hui</creator><creator>Lin, Jen-Kun</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Prevention of Cellular ROS Damage by Isovitexin and Related Flavonoids</title><author>Lin, Chun-Mao ; Chen, Chien-Tsu ; Lee, Hsiao-Hui ; Lin, Jen-Kun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-7f182fbd98c09f1ed90e5cb26fabc01b607f5d3732a569aac8a9aceb30023cfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Apigenin</topic><topic>Biological and medical sciences</topic><topic>Cadmium - pharmacology</topic><topic>DNA Damage - drug effects</topic><topic>Flavonoids - chemistry</topic><topic>Flavonoids - pharmacology</topic><topic>General pharmacology</topic><topic>HL-60 Cells</topic><topic>Humans</topic><topic>Hydrogen Peroxide - metabolism</topic><topic>Letter</topic><topic>Medical sciences</topic><topic>Oryza</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Xanthine - metabolism</topic><topic>Xanthine - pharmacology</topic><topic>Xanthine Oxidase - metabolism</topic><topic>Xanthine Oxidase - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Chun-Mao</creatorcontrib><creatorcontrib>Chen, Chien-Tsu</creatorcontrib><creatorcontrib>Lee, Hsiao-Hui</creatorcontrib><creatorcontrib>Lin, Jen-Kun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Chun-Mao</au><au>Chen, Chien-Tsu</au><au>Lee, Hsiao-Hui</au><au>Lin, Jen-Kun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of Cellular ROS Damage by Isovitexin and Related Flavonoids</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>68</volume><issue>4</issue><spage>365</spage><epage>367</epage><pages>365-367</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
The antioxidant properties of isovitexin and related flavonoids were studied. Isovitexin inhibited xanthine oxidase with an IC
50
value of = 15.2 μM. The flavonoid analogues, apigenin, kaempferol, quercetin, myricetin, and genistein also inhibited xanthine oxidase with IC
50
values of 0.58, 2.18, 1.09, 9.90, and 4.83 μM, respectively. Isovitexin protected DNA from the Fenton reaction-induced breakage in a dose-dependent manner with an IC
50
value of 9.52 μM. Isovitexin also protected HL-60 cells from the ROS damage induced by the xanthine/xanthine oxidase reaction. Isovitexin exhibited the lowest cytotoxicity toward HL-60 cells (LD
50
>400 μM) compared to the other flavonoids examined. In addition, excess hydrogen peroxide induced by cadmium in A2780 ovarian cells was significantly suppressed by isovitexin. These results suggest that isovitexin in rice may protect cells from oxidative stress.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>11988866</pmid><doi>10.1055/s-2002-26753</doi><tpages>3</tpages></addata></record> |
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| subjects | Apigenin Biological and medical sciences Cadmium - pharmacology DNA Damage - drug effects Flavonoids - chemistry Flavonoids - pharmacology General pharmacology HL-60 Cells Humans Hydrogen Peroxide - metabolism Letter Medical sciences Oryza Oxidative Stress - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Reactive Oxygen Species - metabolism Xanthine - metabolism Xanthine - pharmacology Xanthine Oxidase - metabolism Xanthine Oxidase - pharmacology |
| title | Prevention of Cellular ROS Damage by Isovitexin and Related Flavonoids |
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