Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells

We observed that lysophosphatidylglycerol (LPG) stimulates chemotactic migration in human natural killer (NK) cells. The LPG-induced chemotactic migration of NK cells was completely inhibited by pertussis toxin (PTX). LPG also stimulated the extracellular signal-regulated kinase (ERK) and Akt activi...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-07, Vol.372 (1), p.147-151
Hauptverfasser:	Jo, Seong Ho, Kim, Sang Doo, Kim, Jung Mo, Lee, Ha Young, Lee, Sun Young, Shim, Jae Woong, Yun, Jeanho, Im, Dong-Soon, Bae, Yoe-Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Cells, Cultured Chemotaxis Chemotaxis - drug effects Chromones - pharmacology Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Extracellular signal-regulated protein kinase Flavonoids - pharmacology Humans Isoxazoles - pharmacology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lysophosphatidylglycerol Lysophospholipids - immunology Lysophospholipids - pharmacology Morpholines - pharmacology Natural killer cells Pertussis Toxin - pharmacology Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Propionates - pharmacology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Receptors, Lysophosphatidic Acid - agonists Receptors, Lysophosphatidic Acid - metabolism
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