Chemotherapy-Induced Nausea and Vomiting
New insights into the pathophysiology of chemotherapy-induced nausea and vomiting, a better understanding of patients at risk, and the availability of new antiemetic agents have all contributed to substantial improvements in emetic control. This review focuses on our current understanding of chemoth...
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| Veröffentlicht in: | The New England journal of medicine 2008-06, Vol.358 (23), p.2482-2494 |
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| container_title | The New England journal of medicine |
| container_volume | 358 |
| creator | Hesketh, Paul J |
| description | New insights into the pathophysiology of chemotherapy-induced nausea and vomiting, a better understanding of patients at risk, and the availability of new antiemetic agents have all contributed to substantial improvements in emetic control. This review focuses on our current understanding of chemotherapy-induced nausea and vomiting and the status of pharmacologic interventions in its prevention and treatment.
This review focuses on our current understanding of chemotherapy-induced nausea and vomiting and the status of pharmacologic interventions in its prevention and treatment.
The supportive care of patients receiving antineoplastic treatment has dramatically improved over the past two decades. The development of effective means to prevent nausea and vomiting arising from chemotherapy serves as one of the most important examples of this progress. Patients beginning cancer treatment consistently list chemotherapy-induced nausea and vomiting as one of their greatest fears.
1
,
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Inadequately controlled emesis impairs functional activity and quality of life for patients, increases the use of health care resources, and may occasionally compromise adherence to treatment.
3
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New insights into the pathophysiology of chemotherapy-induced nausea and vomiting, a better understanding of the risk . . . |
| doi_str_mv | 10.1056/NEJMra0706547 |
| format | Article |
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This review focuses on our current understanding of chemotherapy-induced nausea and vomiting and the status of pharmacologic interventions in its prevention and treatment.
The supportive care of patients receiving antineoplastic treatment has dramatically improved over the past two decades. The development of effective means to prevent nausea and vomiting arising from chemotherapy serves as one of the most important examples of this progress. Patients beginning cancer treatment consistently list chemotherapy-induced nausea and vomiting as one of their greatest fears.
1
,
2
Inadequately controlled emesis impairs functional activity and quality of life for patients, increases the use of health care resources, and may occasionally compromise adherence to treatment.
3
–
5
New insights into the pathophysiology of chemotherapy-induced nausea and vomiting, a better understanding of the risk . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMra0706547</identifier><identifier>PMID: 18525044</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Animals ; Antiemetics - therapeutic use ; Antineoplastic Agents - adverse effects ; Biological and medical sciences ; Dexamethasone - therapeutic use ; Drug Therapy, Combination ; Female ; General aspects ; Humans ; Male ; Medical sciences ; Morpholines - therapeutic use ; Nausea - chemically induced ; Nausea - prevention & control ; Neoplasms - drug therapy ; Neurokinin-1 Receptor Antagonists ; Risk Factors ; Serotonin 5-HT3 Receptor Antagonists ; Serotonin Antagonists - therapeutic use ; Vomiting - chemically induced ; Vomiting - prevention & control</subject><ispartof>The New England journal of medicine, 2008-06, Vol.358 (23), p.2482-2494</ispartof><rights>Copyright © 2008 Massachusetts Medical Society. All rights reserved.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-9133454ad621b620062e94c73d7e5ed89c58232d775314d4e7a634fb50247cc33</citedby><cites>FETCH-LOGICAL-c305t-9133454ad621b620062e94c73d7e5ed89c58232d775314d4e7a634fb50247cc33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMra0706547$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMra0706547$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20389773$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18525044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hesketh, Paul J</creatorcontrib><title>Chemotherapy-Induced Nausea and Vomiting</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>New insights into the pathophysiology of chemotherapy-induced nausea and vomiting, a better understanding of patients at risk, and the availability of new antiemetic agents have all contributed to substantial improvements in emetic control. This review focuses on our current understanding of chemotherapy-induced nausea and vomiting and the status of pharmacologic interventions in its prevention and treatment.
This review focuses on our current understanding of chemotherapy-induced nausea and vomiting and the status of pharmacologic interventions in its prevention and treatment.
The supportive care of patients receiving antineoplastic treatment has dramatically improved over the past two decades. The development of effective means to prevent nausea and vomiting arising from chemotherapy serves as one of the most important examples of this progress. Patients beginning cancer treatment consistently list chemotherapy-induced nausea and vomiting as one of their greatest fears.
1
,
2
Inadequately controlled emesis impairs functional activity and quality of life for patients, increases the use of health care resources, and may occasionally compromise adherence to treatment.
3
–
5
New insights into the pathophysiology of chemotherapy-induced nausea and vomiting, a better understanding of the risk . . .</description><subject>Animals</subject><subject>Antiemetics - therapeutic use</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Dexamethasone - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Morpholines - therapeutic use</subject><subject>Nausea - chemically induced</subject><subject>Nausea - prevention & control</subject><subject>Neoplasms - drug therapy</subject><subject>Neurokinin-1 Receptor Antagonists</subject><subject>Risk Factors</subject><subject>Serotonin 5-HT3 Receptor Antagonists</subject><subject>Serotonin Antagonists - therapeutic use</subject><subject>Vomiting - chemically induced</subject><subject>Vomiting - prevention & control</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10DtPwzAUBWALgWh5jKyoC4gl4Me1nYyoKlBUygKskWvf0FR1Uuxk6L8nqBEVA3e5y6dzpEPIBaO3jEp1N588vwRDNVUS9AEZMilEAkDVIRlSytMEdCYG5CTGFe2OQXZMBiyVXFKAIbkZL9HXzRKD2WyTaeVai240N21EMzKVG33UvmzK6vOMHBVmHfG8_6fk_WHyNn5KZq-P0_H9LLGCyibJmBAgwTjF2UJxShXHDKwWTqNEl2ZWplxwp7UUDBygNkpAsZCUg7ZWiFNyvcvdhPqrxdjkvowW12tTYd3GXDMFKtOsg8kO2lDHGLDIN6H0JmxzRvOfafI_03T-sg9uFx7dXvdbdOCqByZasy6CqWwZfx2nIs20FnvnfcwrXPl_Cr8Bg1l0WQ</recordid><startdate>20080605</startdate><enddate>20080605</enddate><creator>Hesketh, Paul J</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080605</creationdate><title>Chemotherapy-Induced Nausea and Vomiting</title><author>Hesketh, Paul J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-9133454ad621b620062e94c73d7e5ed89c58232d775314d4e7a634fb50247cc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Antiemetics - therapeutic use</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Dexamethasone - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Morpholines - therapeutic use</topic><topic>Nausea - chemically induced</topic><topic>Nausea - prevention & control</topic><topic>Neoplasms - drug therapy</topic><topic>Neurokinin-1 Receptor Antagonists</topic><topic>Risk Factors</topic><topic>Serotonin 5-HT3 Receptor Antagonists</topic><topic>Serotonin Antagonists - therapeutic use</topic><topic>Vomiting - chemically induced</topic><topic>Vomiting - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hesketh, Paul J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hesketh, Paul J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemotherapy-Induced Nausea and Vomiting</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2008-06-05</date><risdate>2008</risdate><volume>358</volume><issue>23</issue><spage>2482</spage><epage>2494</epage><pages>2482-2494</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>New insights into the pathophysiology of chemotherapy-induced nausea and vomiting, a better understanding of patients at risk, and the availability of new antiemetic agents have all contributed to substantial improvements in emetic control. This review focuses on our current understanding of chemotherapy-induced nausea and vomiting and the status of pharmacologic interventions in its prevention and treatment.
This review focuses on our current understanding of chemotherapy-induced nausea and vomiting and the status of pharmacologic interventions in its prevention and treatment.
The supportive care of patients receiving antineoplastic treatment has dramatically improved over the past two decades. The development of effective means to prevent nausea and vomiting arising from chemotherapy serves as one of the most important examples of this progress. Patients beginning cancer treatment consistently list chemotherapy-induced nausea and vomiting as one of their greatest fears.
1
,
2
Inadequately controlled emesis impairs functional activity and quality of life for patients, increases the use of health care resources, and may occasionally compromise adherence to treatment.
3
–
5
New insights into the pathophysiology of chemotherapy-induced nausea and vomiting, a better understanding of the risk . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>18525044</pmid><doi>10.1056/NEJMra0706547</doi><tpages>13</tpages></addata></record> |
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| ispartof | The New England journal of medicine, 2008-06, Vol.358 (23), p.2482-2494 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Animals Antiemetics - therapeutic use Antineoplastic Agents - adverse effects Biological and medical sciences Dexamethasone - therapeutic use Drug Therapy, Combination Female General aspects Humans Male Medical sciences Morpholines - therapeutic use Nausea - chemically induced Nausea - prevention & control Neoplasms - drug therapy Neurokinin-1 Receptor Antagonists Risk Factors Serotonin 5-HT3 Receptor Antagonists Serotonin Antagonists - therapeutic use Vomiting - chemically induced Vomiting - prevention & control |
| title | Chemotherapy-Induced Nausea and Vomiting |
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