Male antisperm antibodies: association with a modified sperm stress test and lipid peroxidation
We previously reported a modified sperm stress test (MOST), low scores (
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| Veröffentlicht in: | Andrologia 2002-04, Vol.34 (2), p.63-68 |
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| creator | Calamera, J. C. Doncel, G. F. Brugo-Olmedo, S. Sayago, A. Acosta, A. A. |
| description | We previously reported a modified sperm stress test (MOST), low scores ( |
| doi_str_mv | 10.1046/j.0303-4569.2001.00467.x |
| format | Article |
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C. ; Doncel, G. F. ; Brugo-Olmedo, S. ; Sayago, A. ; Acosta, A. A.</creator><creatorcontrib>Calamera, J. C. ; Doncel, G. F. ; Brugo-Olmedo, S. ; Sayago, A. ; Acosta, A. A.</creatorcontrib><description>We previously reported a modified sperm stress test (MOST), low scores (< 0.39) in which were associated with sperm‐related abnormal in vitro fertilization. Preliminary observations suggested that the presence of male sperm antibodies (ASA) could give low MOST scores. It was therefore decided to undertake a study to verify this possible association and also to ascertain if such a relationship was causal in nature. Six hundred and fifty semen samples from patients consulting for infertility were assessed for basic seminal characteristics, motion parameters (CASA), ASA and MOST. Thirty‐nine samples (6%) were ASA‐positive. Samples with and without ASA showed similar characteristics, except for percentage of normal forms and MOST scores (0.35 ± 0.03 vs. 0.67 ± 0.01, P < 0.001, for ASA‐positive and ‐negative, respectively). There was a strong statistical association between presence of ASA and low MOST scores (P < 0.0001). One‐hundred per cent of ASA‐positive samples displayed low MOST scores. To verify the nature of this relationship, we incubated ASA‐free spermatozoa with ASA‐positive and ‐negative (control) sera. Despite an increase in the percentage of ASA‐bearing spermatozoa in those aliquots incubated with ASA‐positive serum, their original (pre‐incubation) MOST scores remained unchanged. Furthermore, the rate of lipid peroxidation, indirectly reflected in MOST scores, was not different in the aliquots incubated with ASA. In conclusion, there seems to be a strong association between presence of ASA and low MOST values in semen samples of infertile patients; however, the relationship does not appear to be causal.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1046/j.0303-4569.2001.00467.x</identifier><identifier>PMID: 11966571</identifier><identifier>CODEN: ANDRDQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science, Ltd</publisher><subject>Antisperm antibodies ; Autoantibodies - analysis ; Biological and medical sciences ; Birth control ; Gynecology. Andrology. Obstetrics ; Humans ; Infertility, Male - immunology ; Infertility, Male - metabolism ; Lipid Peroxidation ; Male ; Medical sciences ; Semen - immunology ; Semen - metabolism ; sperm stress test ; Spermatozoa - immunology ; Spermatozoa - metabolism ; Sterility. Assisted procreation</subject><ispartof>Andrologia, 2002-04, Vol.34 (2), p.63-68</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4827-136f8406c49430cbadfa1091cca5539d50d4787b47b9536c7cbe080231eefec3</citedby><cites>FETCH-LOGICAL-c4827-136f8406c49430cbadfa1091cca5539d50d4787b47b9536c7cbe080231eefec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.0303-4569.2001.00467.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.0303-4569.2001.00467.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13606029$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11966571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calamera, J. C.</creatorcontrib><creatorcontrib>Doncel, G. F.</creatorcontrib><creatorcontrib>Brugo-Olmedo, S.</creatorcontrib><creatorcontrib>Sayago, A.</creatorcontrib><creatorcontrib>Acosta, A. A.</creatorcontrib><title>Male antisperm antibodies: association with a modified sperm stress test and lipid peroxidation</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>We previously reported a modified sperm stress test (MOST), low scores (< 0.39) in which were associated with sperm‐related abnormal in vitro fertilization. Preliminary observations suggested that the presence of male sperm antibodies (ASA) could give low MOST scores. It was therefore decided to undertake a study to verify this possible association and also to ascertain if such a relationship was causal in nature. Six hundred and fifty semen samples from patients consulting for infertility were assessed for basic seminal characteristics, motion parameters (CASA), ASA and MOST. Thirty‐nine samples (6%) were ASA‐positive. Samples with and without ASA showed similar characteristics, except for percentage of normal forms and MOST scores (0.35 ± 0.03 vs. 0.67 ± 0.01, P < 0.001, for ASA‐positive and ‐negative, respectively). There was a strong statistical association between presence of ASA and low MOST scores (P < 0.0001). One‐hundred per cent of ASA‐positive samples displayed low MOST scores. To verify the nature of this relationship, we incubated ASA‐free spermatozoa with ASA‐positive and ‐negative (control) sera. Despite an increase in the percentage of ASA‐bearing spermatozoa in those aliquots incubated with ASA‐positive serum, their original (pre‐incubation) MOST scores remained unchanged. Furthermore, the rate of lipid peroxidation, indirectly reflected in MOST scores, was not different in the aliquots incubated with ASA. In conclusion, there seems to be a strong association between presence of ASA and low MOST values in semen samples of infertile patients; however, the relationship does not appear to be causal.</description><subject>Antisperm antibodies</subject><subject>Autoantibodies - analysis</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infertility, Male - immunology</subject><subject>Infertility, Male - metabolism</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Semen - immunology</subject><subject>Semen - metabolism</subject><subject>sperm stress test</subject><subject>Spermatozoa - immunology</subject><subject>Spermatozoa - metabolism</subject><subject>Sterility. Assisted procreation</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFv0zAUxy0EYtXYV0C-wC3Zc-zYMeIyBhSkMg5MwM1ybEe4JE3xS7Xu289tqu2KL37y-_3s5z8hlEHJQMjLdQkceCFqqcsKgJWQT1W5f0YWTHBdQKWq52TxCJ2RC8Q15CVqpYR4Sc4Y01LWii2I-Wb7QO1mirgNaThW7ehjwHfUIo4u2imOG3oXpz_U0iG3uhg8nWmcUkCkU8Apm572cRs9za1xH_1RfEVedLbHcHHaz8nt50-311-K1ffl1-urVeFEU6mCcdk1AqQTWnBwrfWdZaCZc7auufY1eKEa1QrV6ppLp1wboIGKsxC64Pg5eTtfu03jv10exwwRXeh7uwnjDo1iUuQfVxlsZtClETGFzmxTHGy6NwzMIV6zNofkzCE5c4jXHOM1-6y-Pr2xa4fgn8RTmBl4cwIsOtt3yW5cxCeOS5BQ6cy9n7m72If7_x7AXN18zEXWi1mPOIX9o27TX5O7qja_bpbm93KlfzQ_P5iGPwANp6Vb</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Calamera, J. C.</creator><creator>Doncel, G. F.</creator><creator>Brugo-Olmedo, S.</creator><creator>Sayago, A.</creator><creator>Acosta, A. A.</creator><general>Blackwell Science, Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Male antisperm antibodies: association with a modified sperm stress test and lipid peroxidation</title><author>Calamera, J. C. ; Doncel, G. F. ; Brugo-Olmedo, S. ; Sayago, A. ; Acosta, A. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4827-136f8406c49430cbadfa1091cca5539d50d4787b47b9536c7cbe080231eefec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antisperm antibodies</topic><topic>Autoantibodies - analysis</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infertility, Male - immunology</topic><topic>Infertility, Male - metabolism</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Semen - immunology</topic><topic>Semen - metabolism</topic><topic>sperm stress test</topic><topic>Spermatozoa - immunology</topic><topic>Spermatozoa - metabolism</topic><topic>Sterility. Assisted procreation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calamera, J. C.</creatorcontrib><creatorcontrib>Doncel, G. F.</creatorcontrib><creatorcontrib>Brugo-Olmedo, S.</creatorcontrib><creatorcontrib>Sayago, A.</creatorcontrib><creatorcontrib>Acosta, A. A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calamera, J. C.</au><au>Doncel, G. F.</au><au>Brugo-Olmedo, S.</au><au>Sayago, A.</au><au>Acosta, A. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Male antisperm antibodies: association with a modified sperm stress test and lipid peroxidation</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>34</volume><issue>2</issue><spage>63</spage><epage>68</epage><pages>63-68</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><coden>ANDRDQ</coden><abstract>We previously reported a modified sperm stress test (MOST), low scores (< 0.39) in which were associated with sperm‐related abnormal in vitro fertilization. Preliminary observations suggested that the presence of male sperm antibodies (ASA) could give low MOST scores. It was therefore decided to undertake a study to verify this possible association and also to ascertain if such a relationship was causal in nature. Six hundred and fifty semen samples from patients consulting for infertility were assessed for basic seminal characteristics, motion parameters (CASA), ASA and MOST. Thirty‐nine samples (6%) were ASA‐positive. Samples with and without ASA showed similar characteristics, except for percentage of normal forms and MOST scores (0.35 ± 0.03 vs. 0.67 ± 0.01, P < 0.001, for ASA‐positive and ‐negative, respectively). There was a strong statistical association between presence of ASA and low MOST scores (P < 0.0001). One‐hundred per cent of ASA‐positive samples displayed low MOST scores. To verify the nature of this relationship, we incubated ASA‐free spermatozoa with ASA‐positive and ‐negative (control) sera. Despite an increase in the percentage of ASA‐bearing spermatozoa in those aliquots incubated with ASA‐positive serum, their original (pre‐incubation) MOST scores remained unchanged. Furthermore, the rate of lipid peroxidation, indirectly reflected in MOST scores, was not different in the aliquots incubated with ASA. In conclusion, there seems to be a strong association between presence of ASA and low MOST values in semen samples of infertile patients; however, the relationship does not appear to be causal.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science, Ltd</pub><pmid>11966571</pmid><doi>10.1046/j.0303-4569.2001.00467.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antisperm antibodies Autoantibodies - analysis Biological and medical sciences Birth control Gynecology. Andrology. Obstetrics Humans Infertility, Male - immunology Infertility, Male - metabolism Lipid Peroxidation Male Medical sciences Semen - immunology Semen - metabolism sperm stress test Spermatozoa - immunology Spermatozoa - metabolism Sterility. Assisted procreation |
| title | Male antisperm antibodies: association with a modified sperm stress test and lipid peroxidation |
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