Atenolol in combination with epinephrine improves the initial outcome of cardiopulmonary resuscitation in a swine model of ventricular fibrillation
Abstract Study Objectives The aim of the present study was to assess whether a β -adrenergic blocking agent such as atenolol, administered during cardiopulmonary resuscitation, would improve initial resuscitation success. Methods Ventricular fibrillation was induced in 20 Landrace/Large White piglet...
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| Veröffentlicht in: | The American journal of emergency medicine 2008-06, Vol.26 (5), p.578-584 |
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| creator | Bassiakou, Eleni, MD Xanthos, Theodoros, PhD Koudouna, Eleni, MD Goulas, Sotirios, MD Prapa, Vassiliki, MD Papadimitriou, Dimitrios, MD Rokas, George, MD Papadimitriou, Lila, PhD |
| description | Abstract Study Objectives The aim of the present study was to assess whether a β -adrenergic blocking agent such as atenolol, administered during cardiopulmonary resuscitation, would improve initial resuscitation success. Methods Ventricular fibrillation was induced in 20 Landrace/Large White piglets, which were left untreated for 8 minutes before attempted resuscitation with precordial compression, mechanical ventilation, and electrical defibrillation. Animals were randomized into 2 groups (10 animals each) to receive saline as placebo (20 mL dilution, bolus) + epinephrine (0.02 mg/kg) (group A) or atenolol (0.05 mg/kg per 20 mL dilution, bolus) + epinephrine (0.02 mg/kg) (group B) during cardiopulmonary resuscitation. Electrical defibrillation was attempted after 10 minutes of ventricular fibrillation. Results Nine animals in group B restored spontaneous circulation in comparison to only 4 in group A. Aortic systolic and diastolic pressures as well as coronary perfusion pressure were significantly increased during cardiopulmonary resuscitation in group B. Furthermore, postresuscitation heart rate of the atenolol-treated group was significantly decreased. Conclusions A β -adrenergic blocking agent, when administered during cardiopulmonary resuscitation, significantly improves initial resuscitation success and increases blood and coronary perfusion pressures during cardiopulmonary resuscitation. |
| doi_str_mv | 10.1016/j.ajem.2007.09.010 |
| format | Article |
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Methods Ventricular fibrillation was induced in 20 Landrace/Large White piglets, which were left untreated for 8 minutes before attempted resuscitation with precordial compression, mechanical ventilation, and electrical defibrillation. Animals were randomized into 2 groups (10 animals each) to receive saline as placebo (20 mL dilution, bolus) + epinephrine (0.02 mg/kg) (group A) or atenolol (0.05 mg/kg per 20 mL dilution, bolus) + epinephrine (0.02 mg/kg) (group B) during cardiopulmonary resuscitation. Electrical defibrillation was attempted after 10 minutes of ventricular fibrillation. Results Nine animals in group B restored spontaneous circulation in comparison to only 4 in group A. Aortic systolic and diastolic pressures as well as coronary perfusion pressure were significantly increased during cardiopulmonary resuscitation in group B. Furthermore, postresuscitation heart rate of the atenolol-treated group was significantly decreased. Conclusions A β -adrenergic blocking agent, when administered during cardiopulmonary resuscitation, significantly improves initial resuscitation success and increases blood and coronary perfusion pressures during cardiopulmonary resuscitation.</description><identifier>ISSN: 0735-6757</identifier><identifier>EISSN: 1532-8171</identifier><identifier>DOI: 10.1016/j.ajem.2007.09.010</identifier><identifier>PMID: 18534288</identifier><identifier>CODEN: AJEMEN</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject><![CDATA[Adrenergic beta-Antagonists - administration & dosage ; Adrenergic beta-Antagonists - therapeutic use ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Atenolol - administration & dosage ; Atenolol - therapeutic use ; Biological and medical sciences ; Blood pressure ; Cardiac arrhythmia ; Cardiopulmonary resuscitation ; Cardiopulmonary Resuscitation - methods ; Cardiopulmonary Resuscitation - standards ; Confidence intervals ; CPR ; Drug Therapy, Combination ; Embargoes & blockades ; Emergency ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Emergency medical care ; Epinephrine - administration & dosage ; Epinephrine - therapeutic use ; Female ; Heart attacks ; Heart rate ; Hemodynamics ; Hogs ; Intensive care medicine ; Male ; Medical sciences ; Models, Animal ; Practice Guidelines as Topic ; Random Allocation ; Studies ; Swine ; Vasoconstrictor Agents - administration & dosage ; Vasoconstrictor Agents - therapeutic use ; Veins & arteries ; Ventricular Fibrillation - drug therapy]]></subject><ispartof>The American journal of emergency medicine, 2008-06, Vol.26 (5), p.578-584</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-42b8d36449062d89c7f76b49bc8d819f395c397cd3fe57482df1ff51670966303</citedby><cites>FETCH-LOGICAL-c467t-42b8d36449062d89c7f76b49bc8d819f395c397cd3fe57482df1ff51670966303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1030819814?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20448457$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18534288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bassiakou, Eleni, MD</creatorcontrib><creatorcontrib>Xanthos, Theodoros, PhD</creatorcontrib><creatorcontrib>Koudouna, Eleni, MD</creatorcontrib><creatorcontrib>Goulas, Sotirios, MD</creatorcontrib><creatorcontrib>Prapa, Vassiliki, MD</creatorcontrib><creatorcontrib>Papadimitriou, Dimitrios, MD</creatorcontrib><creatorcontrib>Rokas, George, MD</creatorcontrib><creatorcontrib>Papadimitriou, Lila, PhD</creatorcontrib><title>Atenolol in combination with epinephrine improves the initial outcome of cardiopulmonary resuscitation in a swine model of ventricular fibrillation</title><title>The American journal of emergency medicine</title><addtitle>Am J Emerg Med</addtitle><description>Abstract Study Objectives The aim of the present study was to assess whether a β -adrenergic blocking agent such as atenolol, administered during cardiopulmonary resuscitation, would improve initial resuscitation success. Methods Ventricular fibrillation was induced in 20 Landrace/Large White piglets, which were left untreated for 8 minutes before attempted resuscitation with precordial compression, mechanical ventilation, and electrical defibrillation. Animals were randomized into 2 groups (10 animals each) to receive saline as placebo (20 mL dilution, bolus) + epinephrine (0.02 mg/kg) (group A) or atenolol (0.05 mg/kg per 20 mL dilution, bolus) + epinephrine (0.02 mg/kg) (group B) during cardiopulmonary resuscitation. Electrical defibrillation was attempted after 10 minutes of ventricular fibrillation. Results Nine animals in group B restored spontaneous circulation in comparison to only 4 in group A. Aortic systolic and diastolic pressures as well as coronary perfusion pressure were significantly increased during cardiopulmonary resuscitation in group B. Furthermore, postresuscitation heart rate of the atenolol-treated group was significantly decreased. Conclusions A β -adrenergic blocking agent, when administered during cardiopulmonary resuscitation, significantly improves initial resuscitation success and increases blood and coronary perfusion pressures during cardiopulmonary resuscitation.</description><subject>Adrenergic beta-Antagonists - administration & dosage</subject><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Atenolol - administration & dosage</subject><subject>Atenolol - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Cardiac arrhythmia</subject><subject>Cardiopulmonary resuscitation</subject><subject>Cardiopulmonary Resuscitation - methods</subject><subject>Cardiopulmonary Resuscitation - standards</subject><subject>Confidence intervals</subject><subject>CPR</subject><subject>Drug Therapy, Combination</subject><subject>Embargoes & blockades</subject><subject>Emergency</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Emergency medical care</subject><subject>Epinephrine - administration & dosage</subject><subject>Epinephrine - therapeutic use</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Heart rate</subject><subject>Hemodynamics</subject><subject>Hogs</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Practice Guidelines as Topic</subject><subject>Random Allocation</subject><subject>Studies</subject><subject>Swine</subject><subject>Vasoconstrictor Agents - administration & dosage</subject><subject>Vasoconstrictor Agents - therapeutic use</subject><subject>Veins & arteries</subject><subject>Ventricular Fibrillation - drug therapy</subject><issn>0735-6757</issn><issn>1532-8171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9ksGKFDEQhhtR3NnVF_AgAdHbjEknnaRBhGVxVVjwoIK3kE5XmIzpZEzSs-xz-MKmncGFPXhJCHz_n6r6q2leELwhmPC3u43ewbRpMRYb3G8wwY-aFelou5ZEkMfNCgvarbnoxFlznvMOY0JYx542Z0R2lLVSrprflwVC9NEjF5CJ0-CCLi4GdOvKFsHeBdhvUz2Rm_YpHiCjsq2P4IrTHsW5VBGgaJHRaXRxP_spBp3uUII8Z-PK0a66a5RvF6MpjuAXxQFCSc7MXidk3ZCc93_hZ80Tq32G56f7ovl-_eHb1af1zZePn68ub9aGcVHWrB3kSDljPebtKHsjrOAD6wcjR0l6S_vO0F6YkVroBJPtaIm1HeEC95xTTC-aN0ff2tivGXJRk8sGahUB4pyVIJzxjrEKvnoA7uKcQq1NEUxx_UyShWqPlEkx5wRW7ZOb6igqpJbA1E4tgaklMIV7VQOropcn63mYYLyXnBKqwOsToLPR3iYdjMv_uBYzJlknKvfuyEGd2MFBUnX4EAyMLoEpaozu_3W8fyA3voZcf_wJd5Dv-1W5VVh9XVZr2SwsMOa4_UH_AEZgy3M</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Bassiakou, Eleni, MD</creator><creator>Xanthos, Theodoros, PhD</creator><creator>Koudouna, Eleni, MD</creator><creator>Goulas, Sotirios, MD</creator><creator>Prapa, Vassiliki, MD</creator><creator>Papadimitriou, Dimitrios, MD</creator><creator>Rokas, George, MD</creator><creator>Papadimitriou, Lila, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Atenolol in combination with epinephrine improves the initial outcome of cardiopulmonary resuscitation in a swine model of ventricular fibrillation</title><author>Bassiakou, Eleni, MD ; Xanthos, Theodoros, PhD ; Koudouna, Eleni, MD ; Goulas, Sotirios, MD ; Prapa, Vassiliki, MD ; Papadimitriou, Dimitrios, MD ; Rokas, George, MD ; Papadimitriou, Lila, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-42b8d36449062d89c7f76b49bc8d819f395c397cd3fe57482df1ff51670966303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adrenergic beta-Antagonists - administration & dosage</topic><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Atenolol - administration & dosage</topic><topic>Atenolol - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Cardiac arrhythmia</topic><topic>Cardiopulmonary resuscitation</topic><topic>Cardiopulmonary Resuscitation - methods</topic><topic>Cardiopulmonary Resuscitation - standards</topic><topic>Confidence intervals</topic><topic>CPR</topic><topic>Drug Therapy, Combination</topic><topic>Embargoes & blockades</topic><topic>Emergency</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Emergency medical care</topic><topic>Epinephrine - administration & dosage</topic><topic>Epinephrine - therapeutic use</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Heart rate</topic><topic>Hemodynamics</topic><topic>Hogs</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Practice Guidelines as Topic</topic><topic>Random Allocation</topic><topic>Studies</topic><topic>Swine</topic><topic>Vasoconstrictor Agents - administration & dosage</topic><topic>Vasoconstrictor Agents - therapeutic use</topic><topic>Veins & arteries</topic><topic>Ventricular Fibrillation - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bassiakou, Eleni, MD</creatorcontrib><creatorcontrib>Xanthos, Theodoros, PhD</creatorcontrib><creatorcontrib>Koudouna, Eleni, MD</creatorcontrib><creatorcontrib>Goulas, Sotirios, MD</creatorcontrib><creatorcontrib>Prapa, Vassiliki, MD</creatorcontrib><creatorcontrib>Papadimitriou, Dimitrios, MD</creatorcontrib><creatorcontrib>Rokas, George, MD</creatorcontrib><creatorcontrib>Papadimitriou, Lila, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bassiakou, Eleni, MD</au><au>Xanthos, Theodoros, PhD</au><au>Koudouna, Eleni, MD</au><au>Goulas, Sotirios, MD</au><au>Prapa, Vassiliki, MD</au><au>Papadimitriou, Dimitrios, MD</au><au>Rokas, George, MD</au><au>Papadimitriou, Lila, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atenolol in combination with epinephrine improves the initial outcome of cardiopulmonary resuscitation in a swine model of ventricular fibrillation</atitle><jtitle>The American journal of emergency medicine</jtitle><addtitle>Am J Emerg Med</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>26</volume><issue>5</issue><spage>578</spage><epage>584</epage><pages>578-584</pages><issn>0735-6757</issn><eissn>1532-8171</eissn><coden>AJEMEN</coden><abstract>Abstract Study Objectives The aim of the present study was to assess whether a β -adrenergic blocking agent such as atenolol, administered during cardiopulmonary resuscitation, would improve initial resuscitation success. Methods Ventricular fibrillation was induced in 20 Landrace/Large White piglets, which were left untreated for 8 minutes before attempted resuscitation with precordial compression, mechanical ventilation, and electrical defibrillation. Animals were randomized into 2 groups (10 animals each) to receive saline as placebo (20 mL dilution, bolus) + epinephrine (0.02 mg/kg) (group A) or atenolol (0.05 mg/kg per 20 mL dilution, bolus) + epinephrine (0.02 mg/kg) (group B) during cardiopulmonary resuscitation. Electrical defibrillation was attempted after 10 minutes of ventricular fibrillation. Results Nine animals in group B restored spontaneous circulation in comparison to only 4 in group A. Aortic systolic and diastolic pressures as well as coronary perfusion pressure were significantly increased during cardiopulmonary resuscitation in group B. Furthermore, postresuscitation heart rate of the atenolol-treated group was significantly decreased. Conclusions A β -adrenergic blocking agent, when administered during cardiopulmonary resuscitation, significantly improves initial resuscitation success and increases blood and coronary perfusion pressures during cardiopulmonary resuscitation.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>18534288</pmid><doi>10.1016/j.ajem.2007.09.010</doi><tpages>7</tpages></addata></record> |
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| subjects | Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - therapeutic use Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Atenolol - administration & dosage Atenolol - therapeutic use Biological and medical sciences Blood pressure Cardiac arrhythmia Cardiopulmonary resuscitation Cardiopulmonary Resuscitation - methods Cardiopulmonary Resuscitation - standards Confidence intervals CPR Drug Therapy, Combination Embargoes & blockades Emergency Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Emergency medical care Epinephrine - administration & dosage Epinephrine - therapeutic use Female Heart attacks Heart rate Hemodynamics Hogs Intensive care medicine Male Medical sciences Models, Animal Practice Guidelines as Topic Random Allocation Studies Swine Vasoconstrictor Agents - administration & dosage Vasoconstrictor Agents - therapeutic use Veins & arteries Ventricular Fibrillation - drug therapy |
| title | Atenolol in combination with epinephrine improves the initial outcome of cardiopulmonary resuscitation in a swine model of ventricular fibrillation |
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