Sex and estrous cycle-dependent rapid protein kinase signaling actions of estrogen in distal colonic cells

Previous studies from our laboratory demonstrated that 17β-estradiol (E2) rapidly inhibits Cl − secretion in rat and human distal colonic epithelium. The inhibition has been shown to occur via targeting of a basolateral K + channel identified as the KCNQ1 (KvLQT1) channel. E2 indirectly modulates th...

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Veröffentlicht in:	Steroids 2008-10, Vol.73 (9), p.889-894
Hauptverfasser:	O’Mahony, Fiona, Harvey, Brian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Anti-secretory Biological and medical sciences Colon - cytology Colon - metabolism Colonic crypt Estradiol - metabolism Estrogens - metabolism Estrous Cycle Female Fundamental and applied biological sciences. Psychology Humans Intestines - metabolism KCNQ1 Potassium Channel - metabolism Male Models, Biological Potassium Channels - metabolism Protein kinase Rats Sex Factors Signal Transduction Vertebrates: endocrinology
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