Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube
Olig family is a novel sub-family of basic helix-loop-helix transcription factors recently identified. Olig1 and Olig2 were first reported to promote oligodendrocyte differentiation, and later Olig2 was reported to be involved in motoneuron specification as well. Olig3 was isolated as a third member...
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| Veröffentlicht in: | Mechanisms of development 2002-05, Vol.113 (2), p.169-174 |
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| creator | Takebayashi, Hirohide Ohtsuki, Toshiaki Uchida, Tsukasa Kawamoto, Shoko Okubo, Kosaku Ikenaka, Kazuhiro Takeichi, Masatoshi Chisaka, Osamu Nabeshima, Yo-ichi |
| description | Olig family is a novel sub-family of basic helix-loop-helix transcription factors recently identified. Olig1 and Olig2 were first reported to promote oligodendrocyte differentiation, and later Olig2 was reported to be involved in motoneuron specification as well. Olig3 was isolated as a third member of Olig family, but its precise expression pattern is poorly understood. Here, we describe detailed Olig3 expression analyses in the neural tube of embryonic mice. Olig3 was first detected in the dorsal neural tube from the midbrain/hindbrain boundary to the spinal cord. In E11.5 spinal cord, Olig3 was transiently expressed in the lateral margin of the subventricular zone as three ventral clusters at the level of the p3, p2 and p0 domains, as well as in the dorsal neural tube. Olig3 was co-expressed with Nkx2.2 in the lateral margin of the p3 domain. In forebrain, Olig3 was expressed in the dorsal thalamus while Olig2 was complementarily expressed in the ventral thalamus with an adjacent boundary at E12.5. Olig3 is specifically and transiently expressed in different types of progenitors of embryonic central nervous system and then disappears in the course of development. |
| doi_str_mv | 10.1016/S0925-4773(02)00021-7 |
| format | Article |
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Olig1 and Olig2 were first reported to promote oligodendrocyte differentiation, and later Olig2 was reported to be involved in motoneuron specification as well. Olig3 was isolated as a third member of Olig family, but its precise expression pattern is poorly understood. Here, we describe detailed Olig3 expression analyses in the neural tube of embryonic mice. Olig3 was first detected in the dorsal neural tube from the midbrain/hindbrain boundary to the spinal cord. In E11.5 spinal cord, Olig3 was transiently expressed in the lateral margin of the subventricular zone as three ventral clusters at the level of the p3, p2 and p0 domains, as well as in the dorsal neural tube. Olig3 was co-expressed with Nkx2.2 in the lateral margin of the p3 domain. In forebrain, Olig3 was expressed in the dorsal thalamus while Olig2 was complementarily expressed in the ventral thalamus with an adjacent boundary at E12.5. Olig3 is specifically and transiently expressed in different types of progenitors of embryonic central nervous system and then disappears in the course of development.</description><identifier>ISSN: 0925-4773</identifier><identifier>EISSN: 1872-6356</identifier><identifier>DOI: 10.1016/S0925-4773(02)00021-7</identifier><identifier>PMID: 11960707</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Barhl1 ; Basic helix-loop-helix ; Basic Helix-Loop-Helix Transcription Factors ; Cerebellar neuroepithelium ; D1 interneuron ; Gene Expression ; Immunohistochemistry ; In Situ Hybridization ; Jagged1 ; Mash1 ; Math1 ; MBH1 ; Medaka ; Mice ; Mice, Inbred ICR ; Mouse ; Nerve Tissue Proteins - biosynthesis ; Nervous System - embryology ; Neural Crest - embryology ; Neurogenin2 ; Nkx2.2 ; Olig2 ; Olig3 ; Oligodendrocyte Transcription Factor 2 ; Pax6 ; Pax7 ; Rats ; Rhombic lip ; RNA, Messenger - metabolism ; Thalamus ; Time Factors ; Transcription factor ; Transcription Factors - biosynthesis ; Zebrafish</subject><ispartof>Mechanisms of development, 2002-05, Vol.113 (2), p.169-174</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-6077ce75b0ab4cbecad753e0c0feb5258926022f9093e83fc8f0c8569f1840ee3</citedby><cites>FETCH-LOGICAL-c479t-6077ce75b0ab4cbecad753e0c0feb5258926022f9093e83fc8f0c8569f1840ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0925-4773(02)00021-7$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11960707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takebayashi, Hirohide</creatorcontrib><creatorcontrib>Ohtsuki, Toshiaki</creatorcontrib><creatorcontrib>Uchida, Tsukasa</creatorcontrib><creatorcontrib>Kawamoto, Shoko</creatorcontrib><creatorcontrib>Okubo, Kosaku</creatorcontrib><creatorcontrib>Ikenaka, Kazuhiro</creatorcontrib><creatorcontrib>Takeichi, Masatoshi</creatorcontrib><creatorcontrib>Chisaka, Osamu</creatorcontrib><creatorcontrib>Nabeshima, Yo-ichi</creatorcontrib><title>Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube</title><title>Mechanisms of development</title><addtitle>Mech Dev</addtitle><description>Olig family is a novel sub-family of basic helix-loop-helix transcription factors recently identified. Olig1 and Olig2 were first reported to promote oligodendrocyte differentiation, and later Olig2 was reported to be involved in motoneuron specification as well. Olig3 was isolated as a third member of Olig family, but its precise expression pattern is poorly understood. Here, we describe detailed Olig3 expression analyses in the neural tube of embryonic mice. Olig3 was first detected in the dorsal neural tube from the midbrain/hindbrain boundary to the spinal cord. In E11.5 spinal cord, Olig3 was transiently expressed in the lateral margin of the subventricular zone as three ventral clusters at the level of the p3, p2 and p0 domains, as well as in the dorsal neural tube. Olig3 was co-expressed with Nkx2.2 in the lateral margin of the p3 domain. In forebrain, Olig3 was expressed in the dorsal thalamus while Olig2 was complementarily expressed in the ventral thalamus with an adjacent boundary at E12.5. Olig3 is specifically and transiently expressed in different types of progenitors of embryonic central nervous system and then disappears in the course of development.</description><subject>Animals</subject><subject>Barhl1</subject><subject>Basic helix-loop-helix</subject><subject>Basic Helix-Loop-Helix Transcription Factors</subject><subject>Cerebellar neuroepithelium</subject><subject>D1 interneuron</subject><subject>Gene Expression</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Jagged1</subject><subject>Mash1</subject><subject>Math1</subject><subject>MBH1</subject><subject>Medaka</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Mouse</subject><subject>Nerve Tissue Proteins - biosynthesis</subject><subject>Nervous System - embryology</subject><subject>Neural Crest - embryology</subject><subject>Neurogenin2</subject><subject>Nkx2.2</subject><subject>Olig2</subject><subject>Olig3</subject><subject>Oligodendrocyte Transcription Factor 2</subject><subject>Pax6</subject><subject>Pax7</subject><subject>Rats</subject><subject>Rhombic lip</subject><subject>RNA, Messenger - metabolism</subject><subject>Thalamus</subject><subject>Time Factors</subject><subject>Transcription factor</subject><subject>Transcription Factors - biosynthesis</subject><subject>Zebrafish</subject><issn>0925-4773</issn><issn>1872-6356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EgvL4BJBXCBaBsZPYyQqhiqcqugDWVuJMilFqBzup6N-TPgRLVjOLc-dqDiGnDK4YMHH9CjlPo0TK-AL4JQBwFskdMmKZ5JGIU7FLRr_IATkM4XOAGBNsnxwwlguQIEfk-cXZyC3QN0XbGjuj-N16DME4S11Np42ZxbSw1Xrj1FjafSDFeemXzhpNLfa-aGjXl3hM9uqiCXiynUfk_f7ubfwYTaYPT-PbSaQTmXfRUCw1yrSEokx0ibqoZBojaKixTHma5VwA53UOeYxZXOusBp2lIq9ZlgBifETON3db7756DJ2am6CxaQqLrg9KMpEkEsQAphtQexeCx1q13swLv1QM1EqiWktUK0MKuFpLVHLInW0L-nKO1V9qa20AbjYADm8uDHoVtEGrsTIedacqZ_6p-AFeioCs</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Takebayashi, Hirohide</creator><creator>Ohtsuki, Toshiaki</creator><creator>Uchida, Tsukasa</creator><creator>Kawamoto, Shoko</creator><creator>Okubo, Kosaku</creator><creator>Ikenaka, Kazuhiro</creator><creator>Takeichi, Masatoshi</creator><creator>Chisaka, Osamu</creator><creator>Nabeshima, Yo-ichi</creator><general>Elsevier Ireland Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube</title><author>Takebayashi, Hirohide ; Ohtsuki, Toshiaki ; Uchida, Tsukasa ; Kawamoto, Shoko ; Okubo, Kosaku ; Ikenaka, Kazuhiro ; Takeichi, Masatoshi ; Chisaka, Osamu ; Nabeshima, Yo-ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-6077ce75b0ab4cbecad753e0c0feb5258926022f9093e83fc8f0c8569f1840ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Barhl1</topic><topic>Basic helix-loop-helix</topic><topic>Basic Helix-Loop-Helix Transcription Factors</topic><topic>Cerebellar neuroepithelium</topic><topic>D1 interneuron</topic><topic>Gene Expression</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Jagged1</topic><topic>Mash1</topic><topic>Math1</topic><topic>MBH1</topic><topic>Medaka</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Mouse</topic><topic>Nerve Tissue Proteins - biosynthesis</topic><topic>Nervous System - embryology</topic><topic>Neural Crest - embryology</topic><topic>Neurogenin2</topic><topic>Nkx2.2</topic><topic>Olig2</topic><topic>Olig3</topic><topic>Oligodendrocyte Transcription Factor 2</topic><topic>Pax6</topic><topic>Pax7</topic><topic>Rats</topic><topic>Rhombic lip</topic><topic>RNA, Messenger - metabolism</topic><topic>Thalamus</topic><topic>Time Factors</topic><topic>Transcription factor</topic><topic>Transcription Factors - biosynthesis</topic><topic>Zebrafish</topic><toplevel>online_resources</toplevel><creatorcontrib>Takebayashi, Hirohide</creatorcontrib><creatorcontrib>Ohtsuki, Toshiaki</creatorcontrib><creatorcontrib>Uchida, Tsukasa</creatorcontrib><creatorcontrib>Kawamoto, Shoko</creatorcontrib><creatorcontrib>Okubo, Kosaku</creatorcontrib><creatorcontrib>Ikenaka, Kazuhiro</creatorcontrib><creatorcontrib>Takeichi, Masatoshi</creatorcontrib><creatorcontrib>Chisaka, Osamu</creatorcontrib><creatorcontrib>Nabeshima, Yo-ichi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takebayashi, Hirohide</au><au>Ohtsuki, Toshiaki</au><au>Uchida, Tsukasa</au><au>Kawamoto, Shoko</au><au>Okubo, Kosaku</au><au>Ikenaka, Kazuhiro</au><au>Takeichi, Masatoshi</au><au>Chisaka, Osamu</au><au>Nabeshima, Yo-ichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube</atitle><jtitle>Mechanisms of development</jtitle><addtitle>Mech Dev</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>113</volume><issue>2</issue><spage>169</spage><epage>174</epage><pages>169-174</pages><issn>0925-4773</issn><eissn>1872-6356</eissn><abstract>Olig family is a novel sub-family of basic helix-loop-helix transcription factors recently identified. 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| ispartof | Mechanisms of development, 2002-05, Vol.113 (2), p.169-174 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Barhl1 Basic helix-loop-helix Basic Helix-Loop-Helix Transcription Factors Cerebellar neuroepithelium D1 interneuron Gene Expression Immunohistochemistry In Situ Hybridization Jagged1 Mash1 Math1 MBH1 Medaka Mice Mice, Inbred ICR Mouse Nerve Tissue Proteins - biosynthesis Nervous System - embryology Neural Crest - embryology Neurogenin2 Nkx2.2 Olig2 Olig3 Oligodendrocyte Transcription Factor 2 Pax6 Pax7 Rats Rhombic lip RNA, Messenger - metabolism Thalamus Time Factors Transcription factor Transcription Factors - biosynthesis Zebrafish |
| title | Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube |
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