Synthesis of 5-hydroxy-2,3,4,5-tetrahydro-[1H]-2-benzazepin-4-ones: selective antagonists of muscarinic (M3) receptors

Two approaches to tetrahydro-[1H]-2-benzazepin-4-ones of interest as potentially selective, muscarinic (M(3)) receptor antagonists have been developed. Base promoted addition of 2-(tert-butoxycarbonylamino)methyl-1,3-dithiane with 2-(tert-butyldimethylsiloxymethyl)benzyl chloride gave the correspond...

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Veröffentlicht in:	Organic & biomolecular chemistry 2008-01, Vol.6 (12), p.2138-2157
Hauptverfasser:	Bradshaw, Benjamin, Evans, Paul, Fletcher, Jane, Lee, Alan T L, Mwashimba, Paul G, Oehlrich, Daniel, Thomas, Eric J, Davies, Robin H, Allen, Benjamin C P, Broadley, Kenneth J, Hamrouni, Amar, Escargueil, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Animals Benzazepines - chemical synthesis Benzazepines - pharmacology Crystallography, X-Ray Guinea Pigs Models, Molecular Receptor, Muscarinic M3 - antagonists & inhibitors
Online-Zugang:	Volltext
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