Apical Loop−Internal Loop Interactions:  A New RNA−RNA Recognition Motif Identified through in Vitro Selection against RNA Hairpins of the Hepatitis C Virus mRNA

We performed in vitro selection of oligoribonucleotides in order to identify high-affinity motifs recognizing RNA hairpins located at the 3‘ end (SL1) and at the 5‘ end (domain IV of the internal ribosome entry site) of the hepatitis C virus mRNA. We selected aptamers constituted by an internal loop...

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