Astroglia induce neurogenesis from adult neural stem cells
During an investigation of the mechanisms through which the local environment controls the fate specification of adult neural stem cells, we discovered that adult astrocytes from hippocampus are capable of regulating neurogenesis by instructing the stem cells to adopt a neuronal fate. This role in f...
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| Veröffentlicht in: | Nature (London) 2002-05, Vol.417 (6884), p.39-44 |
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| creator | Stevens, Charles F Gage, Fred H Song, Hongjun |
| description | During an investigation of the mechanisms through which the local environment controls the fate specification of adult neural stem cells, we discovered that adult astrocytes from hippocampus are capable of regulating neurogenesis by instructing the stem cells to adopt a neuronal fate. This role in fate specification was unexpected because, during development, neurons are generated before most of the astrocytes. Our findings, together with recent reports that astrocytes regulate synapse formation and synaptic transmission, reinforce the emerging view that astrocytes have an active regulatory role--rather than merely supportive roles traditionally assigned to them--in the mature central nervous system. |
| doi_str_mv | 10.1038/417039a |
| format | Article |
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| subjects | Aging - physiology Animals Animals, Newborn Astrocytes - physiology Biological and medical sciences Bromodeoxyuridine Cell Differentiation Cell Division Cell Lineage Cell Survival Cells, Cultured Coculture Techniques Culture Media, Serum-Free Development. Senescence. Regeneration. Transplantation Fibroblasts Fundamental and applied biological sciences. Psychology Hippocampus - cytology Hippocampus - growth & development Laminin - metabolism Neurons - cytology Neurons - metabolism Oligodendroglia - physiology Organ Specificity Rats Rats, Inbred F344 Spinal Cord - cytology Spinal Cord - growth & development Stem Cells - cytology Stem Cells - metabolism Vertebrates: nervous system and sense organs |
| title | Astroglia induce neurogenesis from adult neural stem cells |
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