Photodynamic therapy to treat choroidal neovascularisation in highly myopic patients: 4 years’ outcome
Aims:To report the visual outcome in a series of eyes with myopic choroidal neovascularisation treated by photodynamic therapy (PDT) followed during 48 months.Methods:Prospective, consecutive, non-randomised interventional case series. Thirty-nine eyes from 36 highly myopic patients treated by PDT w...
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| Veröffentlicht in: | British journal of ophthalmology 2008-06, Vol.92 (6), p.792-794 |
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| description | Aims:To report the visual outcome in a series of eyes with myopic choroidal neovascularisation treated by photodynamic therapy (PDT) followed during 48 months.Methods:Prospective, consecutive, non-randomised interventional case series. Thirty-nine eyes from 36 highly myopic patients treated by PDT were evaluated. Best corrected visual acuity (BCVA) and fluorescein angiography were performed every 3 months. Multiple regression analysis was used to analyse changes in BCVA in relationship with initial BCVA, spherical equivalent, age, diameter of CNV and chorioretinal atrophy.Results:Mean initial BCVA was 9.0 Early Treatment Diabetic Retinopathy Study lines (SD 4.3). BCVA was 10.4 lines (3.6) at month 12, 9.7 lines (SD 3.9) at month 24, 9.6 lines (SD 3.8) at month 36 and 9.6 lines (SD 4.2) at month 48. BCVA improvement was associated with initial BCVA (p |
| doi_str_mv | 10.1136/bjo.2007.132795 |
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Thirty-nine eyes from 36 highly myopic patients treated by PDT were evaluated. Best corrected visual acuity (BCVA) and fluorescein angiography were performed every 3 months. Multiple regression analysis was used to analyse changes in BCVA in relationship with initial BCVA, spherical equivalent, age, diameter of CNV and chorioretinal atrophy.Results:Mean initial BCVA was 9.0 Early Treatment Diabetic Retinopathy Study lines (SD 4.3). BCVA was 10.4 lines (3.6) at month 12, 9.7 lines (SD 3.9) at month 24, 9.6 lines (SD 3.8) at month 36 and 9.6 lines (SD 4.2) at month 48. BCVA improvement was associated with initial BCVA (p<0.002), lesion diameter (p<0.04) and age (p<0.04) (multiple regression analysis).Conclusions:Our results suggest a better visual outcome for those eyes with better initial BCVA and larger lesions in younger patients treated by PDT. The poorer results for elderly patients with lower initial BCVA might lead us to consider other therapeutic approaches.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.2007.132795</identifier><identifier>PMID: 18523084</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Adult ; Age Factors ; Biological and medical sciences ; Choroidal Neovascularization - complications ; Choroidal Neovascularization - pathology ; Choroidal Neovascularization - therapy ; Diseases of the skin. Cosmetics ; Female ; Fluorescein Angiography ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Myopia - complications ; Myopia - pathology ; Myopia - therapy ; Ophthalmology ; Photochemotherapy - methods ; Photosensitizing Agents - therapeutic use ; Porphyrins - therapeutic use ; Prospective Studies ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Refractive Errors ; Regression Analysis ; Treatment Outcome ; Vision disorders ; Visual Acuity</subject><ispartof>British journal of ophthalmology, 2008-06, Vol.92 (6), p.792-794</ispartof><rights>2008 BMJ Publishing Group Ltd</rights><rights>2008 INIST-CNRS</rights><rights>Copyright: 2008 2008 BMJ Publishing Group Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b533t-ffaf84908eb4a6cc9fe715e000065e643a60107fc0e706164837102d9996e3363</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bjo.bmj.com/content/92/6/792.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://bjo.bmj.com/content/92/6/792.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3194,23569,27922,27923,77370,77401</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20377851$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18523084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruiz-Moreno, J M</creatorcontrib><creatorcontrib>Amat, P</creatorcontrib><creatorcontrib>Montero, J A</creatorcontrib><creatorcontrib>Lugo, F</creatorcontrib><title>Photodynamic therapy to treat choroidal neovascularisation in highly myopic patients: 4 years’ outcome</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Aims:To report the visual outcome in a series of eyes with myopic choroidal neovascularisation treated by photodynamic therapy (PDT) followed during 48 months.Methods:Prospective, consecutive, non-randomised interventional case series. Thirty-nine eyes from 36 highly myopic patients treated by PDT were evaluated. Best corrected visual acuity (BCVA) and fluorescein angiography were performed every 3 months. Multiple regression analysis was used to analyse changes in BCVA in relationship with initial BCVA, spherical equivalent, age, diameter of CNV and chorioretinal atrophy.Results:Mean initial BCVA was 9.0 Early Treatment Diabetic Retinopathy Study lines (SD 4.3). BCVA was 10.4 lines (3.6) at month 12, 9.7 lines (SD 3.9) at month 24, 9.6 lines (SD 3.8) at month 36 and 9.6 lines (SD 4.2) at month 48. BCVA improvement was associated with initial BCVA (p<0.002), lesion diameter (p<0.04) and age (p<0.04) (multiple regression analysis).Conclusions:Our results suggest a better visual outcome for those eyes with better initial BCVA and larger lesions in younger patients treated by PDT. The poorer results for elderly patients with lower initial BCVA might lead us to consider other therapeutic approaches.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Choroidal Neovascularization - complications</subject><subject>Choroidal Neovascularization - pathology</subject><subject>Choroidal Neovascularization - therapy</subject><subject>Diseases of the skin. Cosmetics</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Myopia - complications</subject><subject>Myopia - pathology</subject><subject>Myopia - therapy</subject><subject>Ophthalmology</subject><subject>Photochemotherapy - methods</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Porphyrins - therapeutic use</subject><subject>Prospective Studies</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Refractive Errors</subject><subject>Regression Analysis</subject><subject>Treatment Outcome</subject><subject>Vision disorders</subject><subject>Visual Acuity</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkcFu1DAQhi0EosvCmRuyhMoBKVtPnNgxt2pFW6QVUAkQN8vxOsRLEgfbQeTGa_B6fZK6yqpIXDhZ9nz_-J_5EXoOZANA2Vl9cJucEL4BmnNRPkArKFiV5YSLh2hFUiUDYHCCnoRwSNecAX-MTqAqc0qqYoXaj62Lbj8Pqrcax9Z4Nc44Ohy9URHr1nln96rDg3E_VdBTp7wNKlo3YDvg1n5ruxn3sxuTfEzvZojhDS7wbJQPN7__YDdF7XrzFD1qVBfMs-O5Rp8v3n7aXmW7D5fvtue7rC4pjVnTqKYqBKlMXSimtWgMh9Ik64SVhhVUMQKEN5oYThiwoqIcSL4XQjBDKaNr9GrpO3r3YzIhyt4GbbpOpQmmIHnS5DSNv0Yv_wEPbvJD8iaB80rkAhhN1NlCae9C8KaRo7e98rMEIu8ikCkCeReBXCJIihfHvlPdm_1f_rjzBJwegbRP1TVeDdqGey4nNH1fQuKyhbMhml_3deW_S8YpL-X7L1t5fXF1uavEV3md-NcLX_eH_7q8BUbqq9U</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Ruiz-Moreno, J M</creator><creator>Amat, P</creator><creator>Montero, J A</creator><creator>Lugo, F</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Photodynamic therapy to treat choroidal neovascularisation in highly myopic patients: 4 years’ outcome</title><author>Ruiz-Moreno, J M ; Amat, P ; Montero, J A ; Lugo, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b533t-ffaf84908eb4a6cc9fe715e000065e643a60107fc0e706164837102d9996e3363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Choroidal Neovascularization - complications</topic><topic>Choroidal Neovascularization - pathology</topic><topic>Choroidal Neovascularization - therapy</topic><topic>Diseases of the skin. Cosmetics</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Myopia - complications</topic><topic>Myopia - pathology</topic><topic>Myopia - therapy</topic><topic>Ophthalmology</topic><topic>Photochemotherapy - methods</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Porphyrins - therapeutic use</topic><topic>Prospective Studies</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Refractive Errors</topic><topic>Regression Analysis</topic><topic>Treatment Outcome</topic><topic>Vision disorders</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruiz-Moreno, J M</creatorcontrib><creatorcontrib>Amat, P</creatorcontrib><creatorcontrib>Montero, J A</creatorcontrib><creatorcontrib>Lugo, F</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruiz-Moreno, J M</au><au>Amat, P</au><au>Montero, J A</au><au>Lugo, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photodynamic therapy to treat choroidal neovascularisation in highly myopic patients: 4 years’ outcome</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>92</volume><issue>6</issue><spage>792</spage><epage>794</epage><pages>792-794</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>Aims:To report the visual outcome in a series of eyes with myopic choroidal neovascularisation treated by photodynamic therapy (PDT) followed during 48 months.Methods:Prospective, consecutive, non-randomised interventional case series. Thirty-nine eyes from 36 highly myopic patients treated by PDT were evaluated. Best corrected visual acuity (BCVA) and fluorescein angiography were performed every 3 months. Multiple regression analysis was used to analyse changes in BCVA in relationship with initial BCVA, spherical equivalent, age, diameter of CNV and chorioretinal atrophy.Results:Mean initial BCVA was 9.0 Early Treatment Diabetic Retinopathy Study lines (SD 4.3). BCVA was 10.4 lines (3.6) at month 12, 9.7 lines (SD 3.9) at month 24, 9.6 lines (SD 3.8) at month 36 and 9.6 lines (SD 4.2) at month 48. BCVA improvement was associated with initial BCVA (p<0.002), lesion diameter (p<0.04) and age (p<0.04) (multiple regression analysis).Conclusions:Our results suggest a better visual outcome for those eyes with better initial BCVA and larger lesions in younger patients treated by PDT. The poorer results for elderly patients with lower initial BCVA might lead us to consider other therapeutic approaches.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>18523084</pmid><doi>10.1136/bjo.2007.132795</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Biological and medical sciences Choroidal Neovascularization - complications Choroidal Neovascularization - pathology Choroidal Neovascularization - therapy Diseases of the skin. Cosmetics Female Fluorescein Angiography Follow-Up Studies Humans Male Medical sciences Middle Aged Miscellaneous Myopia - complications Myopia - pathology Myopia - therapy Ophthalmology Photochemotherapy - methods Photosensitizing Agents - therapeutic use Porphyrins - therapeutic use Prospective Studies Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Refractive Errors Regression Analysis Treatment Outcome Vision disorders Visual Acuity |
| title | Photodynamic therapy to treat choroidal neovascularisation in highly myopic patients: 4 years’ outcome |
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