Covalent split protein fragment-DNA hybrids generated through N-terminus-specific modification of proteins by oligonucleotides

Semisynthetic protein-DNA hybrid molecules have recently attracted much attention as valuable tools for bioanalytical chemistry and nanobiotechnology. Here we describe a synthetic method for conjugating oligonucleotides to the N-terminus of recombinant proteins. Our strategy involves the conversion...

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Veröffentlicht in:	Organic & biomolecular chemistry 2008-06, Vol.6 (12), p.2187-2194
Hauptverfasser:	Takeda, Shuji, Tsukiji, Shinya, Ueda, Hiroshi, Nagamune, Teruyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Chromatography, High Pressure Liquid Oligonucleotides - chemistry Proteins - chemistry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Online-Zugang:	Volltext
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