The V(D)J Recombinase Efficiently Cleaves and Transposes Signal Joints

V(D)J recombination generates two types of products: coding joints, which constitute the rearranged variable regions of antigen receptor genes, and signal joints, which often form on immunologically irrelevant, excised circular molecules that are lost during cell division. It has been widely believe...

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Veröffentlicht in:	Molecular cell 2002-04, Vol.9 (4), p.871-878
Hauptverfasser:	Neiditch, Matthew B, Lee, Gregory S, Huye, Leslie E, Brandt, Vicky L, Roth, David B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals CHO Cells - enzymology Cricetinae Cricetulus DNA Nucleotidyltransferases - metabolism DNA, Circular - metabolism DNA, Recombinant - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endonucleases - metabolism Homeodomain Proteins - chemistry Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Mice Models, Genetic Plasmids - metabolism Recombinant Fusion Proteins - metabolism Recombination, Genetic - genetics Regulatory Sequences, Nucleic Acid Substrate Specificity Transfection VDJ Recombinases
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