Staphylococcal Exfoliative Toxin B Specifically Cleaves Desmoglein 1

Staphylococcal scalded skin syndrome and its localized form, bullous impetigo, show superficial epidermal blister formation caused by exfoliative toxin A or B produced by Staphylococcus aureus. Recently we have demonstrated that exfoliative toxin A specifically cleaves desmoglein 1, a desmosomal adh...

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Veröffentlicht in:	Journal of investigative dermatology 2002-05, Vol.118 (5), p.845-850
Hauptverfasser:	Amagai, Masayuki, Nishifuji, Koji, Yamaguchi, Takayuki, Hanakawa, Yasushi, Sugai, Motoyuki, Stanley, John R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Blister - metabolism Blister - pathology cadherin Cadherins - genetics Cadherins - metabolism Cells, Cultured Dermatology Desmoglein 1 Desmoglein 3 Epidermis - metabolism Epidermis - pathology Exfoliatins - metabolism Exfoliatins - pharmacology Humans impetigo Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - metabolism Medical sciences Mice Mice, Inbred BALB C Mice, Inbred ICR pemphigus foliaceus Recombinant Proteins - genetics Recombinant Proteins - metabolism skin infection Skin involvement in other diseases. Miscellaneous. General aspects SSSS Staphylococcal Scalded Skin Syndrome - metabolism Staphylococcal Scalded Skin Syndrome - pathology
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