A role for p53 in terminal epithelial cell differentiation

Terminal epithelial cell differentiation is a crucial step in development. In the kidney, failure of terminal differentiation causes dysplasia, cystogenesis, and cancer. The present study provides multiple lines of evidence implicating the tumor suppressor protein p53 in terminal differentiation of...

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Veröffentlicht in:	The Journal of clinical investigation 2002-04, Vol.109 (8), p.1021-1030
Hauptverfasser:	Saifudeen, Zubaida, Dipp, Susana, El-Dahr, Samir S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - physiology Epithelial Cells - cytology Gene Expression Genes, p53 Humans Kidney - cytology Kidney - growth & development Kidney - metabolism Mice Mice, Inbred C57BL Mice, Knockout Models, Biological Promoter Regions, Genetic Rats Receptor, Bradykinin B2 Receptors, Bradykinin - genetics Tumor Suppressor Protein p53 - physiology
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