HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the japanese population
Autoimmune pancreatitis is a distinctive disease entity characterized by high serum immunoglobulin G4 concentrations. Because of the close association between some autoimmune diseases and particular alleles of major histocompatibility complex genes, we investigated the association between HLA allele...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2002-05, Vol.122 (5), p.1264-1269 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
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| creator | Kawa, Shigeyuki Ota, Masao Yoshizawa, Kaname Horiuchi, Akira Hamano, Hideaki Ochi, Yasuhide Nakayama, Kohzo Tokutake, Yuriko Katsuyama, Yoshihiko Saito, Satoshi Hasebe, Osamu Kiyosawa, Kendo |
| description | Autoimmune pancreatitis is a distinctive disease entity characterized by high serum immunoglobulin G4 concentrations. Because of the close association between some autoimmune diseases and particular alleles of major histocompatibility complex genes, we investigated the association between HLA alleles and autoimmune pancreatitis.
HIA-A. -B. -C. -DR. and -DQ gene typing and HLA-DRB1, -DQB1, and -DPB1 allele typing were performed by the polymerase chain reaction sequence-specific primers method and the restriction fragment length polymorphism method, respectively, in 40 patients with autoimmune pancreatitis, 43 patients with chronic calcifying pancreatitis, and 201 healthy subjects.
In patients with autoimmune pancreatitis compared with healthy subjects, we found a significant increase in DR4 (73% vs. 44%, corrected P = 0.01) and DRB1*0405 (58% vs. 21%, corrected P = 0.000026) and DQ4 (58% vs. 26%, corrected P = 0.001) and DQB1*0401 (58% vs. 21%, corrected P = 0.000017). The DRB1*0405-DQB1*0401 haplotype in autoimmune pancreatitis showed no significant association with any HLA class I antigens, in contrast to the B54DRB1*0405-DQB1*0401 haplotype reported in autoimmune hepatitis. The frequencies of DRB1*0405 and DQB1*0401 were significantly high in patients with autoimmune panpreatitis compared with chronic calcifying pancreatitis.
It is probable that DRB1*0405-DQB1*0401 haplotype is associated with autoimmune pancreatitis in the Japanese population. |
| doi_str_mv | 10.1053/gast.2002.33022 |
| format | Article |
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HIA-A. -B. -C. -DR. and -DQ gene typing and HLA-DRB1, -DQB1, and -DPB1 allele typing were performed by the polymerase chain reaction sequence-specific primers method and the restriction fragment length polymorphism method, respectively, in 40 patients with autoimmune pancreatitis, 43 patients with chronic calcifying pancreatitis, and 201 healthy subjects.
In patients with autoimmune pancreatitis compared with healthy subjects, we found a significant increase in DR4 (73% vs. 44%, corrected P = 0.01) and DRB1*0405 (58% vs. 21%, corrected P = 0.000026) and DQ4 (58% vs. 26%, corrected P = 0.001) and DQB1*0401 (58% vs. 21%, corrected P = 0.000017). The DRB1*0405-DQB1*0401 haplotype in autoimmune pancreatitis showed no significant association with any HLA class I antigens, in contrast to the B54DRB1*0405-DQB1*0401 haplotype reported in autoimmune hepatitis. The frequencies of DRB1*0405 and DQB1*0401 were significantly high in patients with autoimmune panpreatitis compared with chronic calcifying pancreatitis.
It is probable that DRB1*0405-DQB1*0401 haplotype is associated with autoimmune pancreatitis in the Japanese population.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1053/gast.2002.33022</identifier><identifier>PMID: 11984513</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Autoimmune Diseases - genetics ; Biological and medical sciences ; Calcinosis - genetics ; Chronic Disease ; Digestive system ; Female ; Haplotypes ; HLA-DR Antigens - genetics ; HLA-DRB1 Chains ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Japan ; Male ; Medical sciences ; Middle Aged ; Pancreatitis - genetics ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 2002-05, Vol.122 (5), p.1264-1269</ispartof><rights>2002 American Gastroenterology Association</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-fbca7b478f7b106e8407ade76b2bd6e95f5fab29449dbf5471ed28b7eda9fcbc3</citedby><cites>FETCH-LOGICAL-c346t-fbca7b478f7b106e8407ade76b2bd6e95f5fab29449dbf5471ed28b7eda9fcbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0016508502682411$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13659360$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11984513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawa, Shigeyuki</creatorcontrib><creatorcontrib>Ota, Masao</creatorcontrib><creatorcontrib>Yoshizawa, Kaname</creatorcontrib><creatorcontrib>Horiuchi, Akira</creatorcontrib><creatorcontrib>Hamano, Hideaki</creatorcontrib><creatorcontrib>Ochi, Yasuhide</creatorcontrib><creatorcontrib>Nakayama, Kohzo</creatorcontrib><creatorcontrib>Tokutake, Yuriko</creatorcontrib><creatorcontrib>Katsuyama, Yoshihiko</creatorcontrib><creatorcontrib>Saito, Satoshi</creatorcontrib><creatorcontrib>Hasebe, Osamu</creatorcontrib><creatorcontrib>Kiyosawa, Kendo</creatorcontrib><title>HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the japanese population</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>Autoimmune pancreatitis is a distinctive disease entity characterized by high serum immunoglobulin G4 concentrations. Because of the close association between some autoimmune diseases and particular alleles of major histocompatibility complex genes, we investigated the association between HLA alleles and autoimmune pancreatitis.
HIA-A. -B. -C. -DR. and -DQ gene typing and HLA-DRB1, -DQB1, and -DPB1 allele typing were performed by the polymerase chain reaction sequence-specific primers method and the restriction fragment length polymorphism method, respectively, in 40 patients with autoimmune pancreatitis, 43 patients with chronic calcifying pancreatitis, and 201 healthy subjects.
In patients with autoimmune pancreatitis compared with healthy subjects, we found a significant increase in DR4 (73% vs. 44%, corrected P = 0.01) and DRB1*0405 (58% vs. 21%, corrected P = 0.000026) and DQ4 (58% vs. 26%, corrected P = 0.001) and DQB1*0401 (58% vs. 21%, corrected P = 0.000017). The DRB1*0405-DQB1*0401 haplotype in autoimmune pancreatitis showed no significant association with any HLA class I antigens, in contrast to the B54DRB1*0405-DQB1*0401 haplotype reported in autoimmune hepatitis. The frequencies of DRB1*0405 and DQB1*0401 were significantly high in patients with autoimmune panpreatitis compared with chronic calcifying pancreatitis.
It is probable that DRB1*0405-DQB1*0401 haplotype is associated with autoimmune pancreatitis in the Japanese population.</description><subject>Adult</subject><subject>Aged</subject><subject>Autoimmune Diseases - genetics</subject><subject>Biological and medical sciences</subject><subject>Calcinosis - genetics</subject><subject>Chronic Disease</subject><subject>Digestive system</subject><subject>Female</subject><subject>Haplotypes</subject><subject>HLA-DR Antigens - genetics</subject><subject>HLA-DRB1 Chains</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Japan</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pancreatitis - genetics</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPHDEMgCPUCraUM7cql_Y2Sx6TeRx5tFBppaqInqM8nG7QzGRIMiD-fbPsSpx6smV_tuwPoXNK1pQIfvFXpbxmhLA154SxI7SignUVIZR9QKsSmkqQTpygTyk9EkJ63tFjdEJp39WC8hWCu80lvrm_oqQmorr5_ZZQvFXzEPLrDNgnrFIKxqsMFr_4vMVqycGP4zIBntVkIqjsc-H8hPMW8KMqVUilGeZlKL0wfUYfnRoSnB3iKfrz4_vD9V21-XX78_pyUxleN7ly2qhW123nWk1JA11NWmWhbTTTtoFeOOGUZn1d91Y7UbcULOt0C1b1zmjDT9G3_d45hqcFUpajTwaGoRwUliRb2vDyOS3gxR40MaQUwck5-lHFV0mJ3JmVO7NyZ1a-mS0TXw6rFz2CfecPKgvw9QCoZNTgYlHj0zvHG9HzhhSu33NQRDx7iDIZD5MB6yOYLG3w_z3iH9GplQI</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Kawa, Shigeyuki</creator><creator>Ota, Masao</creator><creator>Yoshizawa, Kaname</creator><creator>Horiuchi, Akira</creator><creator>Hamano, Hideaki</creator><creator>Ochi, Yasuhide</creator><creator>Nakayama, Kohzo</creator><creator>Tokutake, Yuriko</creator><creator>Katsuyama, Yoshihiko</creator><creator>Saito, Satoshi</creator><creator>Hasebe, Osamu</creator><creator>Kiyosawa, Kendo</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the japanese population</title><author>Kawa, Shigeyuki ; Ota, Masao ; Yoshizawa, Kaname ; Horiuchi, Akira ; Hamano, Hideaki ; Ochi, Yasuhide ; Nakayama, Kohzo ; Tokutake, Yuriko ; Katsuyama, Yoshihiko ; Saito, Satoshi ; Hasebe, Osamu ; Kiyosawa, Kendo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-fbca7b478f7b106e8407ade76b2bd6e95f5fab29449dbf5471ed28b7eda9fcbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Autoimmune Diseases - genetics</topic><topic>Biological and medical sciences</topic><topic>Calcinosis - genetics</topic><topic>Chronic Disease</topic><topic>Digestive system</topic><topic>Female</topic><topic>Haplotypes</topic><topic>HLA-DR Antigens - genetics</topic><topic>HLA-DRB1 Chains</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Japan</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pancreatitis - genetics</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawa, Shigeyuki</creatorcontrib><creatorcontrib>Ota, Masao</creatorcontrib><creatorcontrib>Yoshizawa, Kaname</creatorcontrib><creatorcontrib>Horiuchi, Akira</creatorcontrib><creatorcontrib>Hamano, Hideaki</creatorcontrib><creatorcontrib>Ochi, Yasuhide</creatorcontrib><creatorcontrib>Nakayama, Kohzo</creatorcontrib><creatorcontrib>Tokutake, Yuriko</creatorcontrib><creatorcontrib>Katsuyama, Yoshihiko</creatorcontrib><creatorcontrib>Saito, Satoshi</creatorcontrib><creatorcontrib>Hasebe, Osamu</creatorcontrib><creatorcontrib>Kiyosawa, Kendo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawa, Shigeyuki</au><au>Ota, Masao</au><au>Yoshizawa, Kaname</au><au>Horiuchi, Akira</au><au>Hamano, Hideaki</au><au>Ochi, Yasuhide</au><au>Nakayama, Kohzo</au><au>Tokutake, Yuriko</au><au>Katsuyama, Yoshihiko</au><au>Saito, Satoshi</au><au>Hasebe, Osamu</au><au>Kiyosawa, Kendo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the japanese population</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>122</volume><issue>5</issue><spage>1264</spage><epage>1269</epage><pages>1264-1269</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>Autoimmune pancreatitis is a distinctive disease entity characterized by high serum immunoglobulin G4 concentrations. Because of the close association between some autoimmune diseases and particular alleles of major histocompatibility complex genes, we investigated the association between HLA alleles and autoimmune pancreatitis.
HIA-A. -B. -C. -DR. and -DQ gene typing and HLA-DRB1, -DQB1, and -DPB1 allele typing were performed by the polymerase chain reaction sequence-specific primers method and the restriction fragment length polymorphism method, respectively, in 40 patients with autoimmune pancreatitis, 43 patients with chronic calcifying pancreatitis, and 201 healthy subjects.
In patients with autoimmune pancreatitis compared with healthy subjects, we found a significant increase in DR4 (73% vs. 44%, corrected P = 0.01) and DRB1*0405 (58% vs. 21%, corrected P = 0.000026) and DQ4 (58% vs. 26%, corrected P = 0.001) and DQB1*0401 (58% vs. 21%, corrected P = 0.000017). The DRB1*0405-DQB1*0401 haplotype in autoimmune pancreatitis showed no significant association with any HLA class I antigens, in contrast to the B54DRB1*0405-DQB1*0401 haplotype reported in autoimmune hepatitis. The frequencies of DRB1*0405 and DQB1*0401 were significantly high in patients with autoimmune panpreatitis compared with chronic calcifying pancreatitis.
It is probable that DRB1*0405-DQB1*0401 haplotype is associated with autoimmune pancreatitis in the Japanese population.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11984513</pmid><doi>10.1053/gast.2002.33022</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gastroenterology (New York, N.Y. 1943), 2002-05, Vol.122 (5), p.1264-1269 |
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| subjects | Adult Aged Autoimmune Diseases - genetics Biological and medical sciences Calcinosis - genetics Chronic Disease Digestive system Female Haplotypes HLA-DR Antigens - genetics HLA-DRB1 Chains Humans Investigative techniques, diagnostic techniques (general aspects) Japan Male Medical sciences Middle Aged Pancreatitis - genetics Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques |
| title | HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the japanese population |
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