Recombinant human transgenic Antithrombin in cardiac surgery: A dose-finding study

Acquired antithrombin III (AT) deficiency may render heparin less effective during cardiac surgery and cardiopulmonary bypass (CPB). The authors examined the pharmacodynamics and optimal dose of recombinant human AT (rh-AT) needed to maintain normal AT activity during CPB, optimize the anticoagulant...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2002-05, Vol.96 (5), p.1095-1102
Hauptverfasser:	LEVY, Jerrold H, DESPOTIS, George J, SZLAM, Fania, OLSON, Peter, MEEKER, David, WEISINGER, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antithrombin III - administration & dosage Antithrombin III - adverse effects Antithrombin III - therapeutic use Antithrombin III Deficiency - complications Antithrombin III Deficiency - drug therapy Biological and medical sciences Blood Coagulation - drug effects Blood Transfusion Cardiac Surgical Procedures Cohort Studies Coronary Artery Bypass Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Female Humans Male Medical sciences Middle Aged Recombinant Proteins - administration & dosage Recombinant Proteins - adverse effects Recombinant Proteins - therapeutic use Serine Proteinase Inhibitors - administration & dosage Serine Proteinase Inhibitors - adverse effects Serine Proteinase Inhibitors - therapeutic use Thoracic and cardiovascular surgery. Cardiopulmonary bypass Transgenes
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