Delay of Corneal Epithelial Wound Healing and Induction of Keratocyte Apoptosis by Platelet-Activating Factor

To examine the role of the lipid mediator platelet-activating factor (PAF) in epithelial wound healing. A 7-mm central de-epithelializing wound was produced in rabbit corneas, and the tissue was incubated with 125 nM carbamyl PAF (cPAF), an analogue of PAF. Rabbit corneal epithelial and stromal cell...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2002-05, Vol.43 (5), p.1422-1428
Hauptverfasser:	Chandrasekher, Gudiseva, Ma, Xiang, Lallier, Thomas E, Bazan, Haydee E. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Cell Adhesion - drug effects Cell Division - drug effects Cell Movement - drug effects Cells, Cultured Corneal Stroma - drug effects Corneal Stroma - pathology Diseases of cornea, anterior segment and sclera Epithelium, Corneal - drug effects Epithelium, Corneal - injuries Fibroblasts - drug effects Fibroblasts - pathology Humans In Situ Nick-End Labeling Medical sciences Ophthalmology Organ Culture Techniques Phospholipid Ethers - antagonists & inhibitors Phospholipid Ethers - pharmacology Rabbits Wound Healing - drug effects
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