Randomized, Blinded, Placebo-Controlled Clinical Trial of N-Acetylcysteine in Dogs With Spinal Cord Trauma From Acute Intervertebral Disc Disease

The effect of N-acetylcysteine administration intravenously before hemilaminectomy surgery on neurologic outcome and 15F 2t isoprostane excretion in dogs was examined in a blinded, placebo-controlled trial. To determine the effect of N-acetylcysteine administration on urinary 15F 2t isoprostane excr...

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Veröffentlicht in:	Spine (Philadelphia, Pa. 1976) Pa. 1976), 2008-06, Vol.33 (13), p.1397-1402
Hauptverfasser:	BALTZER, Wendy I, MCMICHAEL, Maureen A, HOSGOOD, Giselle L, KERWIN, Sharon C, LEVINE, Jonathan M, STEINER, Jorg M, RUAUX, Craig G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - administration & dosage Acetylcysteine - pharmacology Animals Antioxidants - pharmacology Antioxidants - therapeutic use Biological and medical sciences Biomarkers - urine Cerebrospinal fluid. Meninges. Spinal cord Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dinoprost - analogs & derivatives Dinoprost - urine Disease Models, Animal Dog Diseases - drug therapy Dog Diseases - metabolism Dog Diseases - surgery Dogs Female Infusions, Intravenous Intervertebral Disc - drug effects Intervertebral Disc - metabolism Intervertebral Disc - surgery Intervertebral Disc Displacement - complications Intervertebral Disc Displacement - drug therapy Intervertebral Disc Displacement - metabolism Intervertebral Disc Displacement - surgery Intervertebral Disc Displacement - veterinary Laminectomy - veterinary Male Medical sciences Nervous system (semeiology, syndromes) Neurology Oxidative Stress - drug effects Random Allocation Spinal Cord Injuries - etiology Spinal Cord Injuries - metabolism Spinal Cord Injuries - prevention & control Spinal Cord Injuries - veterinary Time Factors
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