CONGENITAL TOXOPLASMOSIS: SPECIFIC IgG SUBCLASSES IN MOTHER/NEWBORN PAIRS

Anti-Toxoplasma gondii antibodies of all IgG subclasses were studied in mother/newborn pairs. IgG1 in the mothers and IgG3 in the newborns were related to offspring clinical problems; IgG2 and IgG3 in the babies were markers of vertical transmission, and IgG4 in mothers or children were associated t...

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Veröffentlicht in:	The Pediatric infectious disease journal 2008-05, Vol.27 (5), p.469-474
Hauptverfasser:	Cañedo-Solares, Irma, Galván-Ramírez, María de la Luz, Luna-Pastén, Héctor, Rodríguez Pérez, Laura Rocío, Ortiz-Alegría, Luz Belinda, Rico-Torres, Claudia Patricia, Vela-Amieva, Marcela, Pérez-Andrade, Martha, Figueroa-Damián, Ricardo, Correa, Dolores
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Protozoan - blood Biological and medical sciences Biomarkers Human protozoal diseases Humans Immunoglobulin G - blood Infant, Newborn Infectious diseases Medical sciences Mothers Parasitic diseases Prognosis Protozoal diseases Toxoplasma - immunology Toxoplasmosis Toxoplasmosis, Congenital - diagnosis Toxoplasmosis, Congenital - immunology
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Zusammenfassung:	Anti-Toxoplasma gondii antibodies of all IgG subclasses were studied in mother/newborn pairs. IgG1 in the mothers and IgG3 in the newborns were related to offspring clinical problems; IgG2 and IgG3 in the babies were markers of vertical transmission, and IgG4 in mothers or children were associated to clinical problems. IgG subclasses may be markers of congenital infection or clinical outcome.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0b013e31816591df