Fibrinogen Hershey IV: a novel dysfibrinogen with a gammaV411I mutation in the integrin alpha(IIb)beta(3) binding site

The carboxyl terminal segment of the fibrinogen gamma chain from gamma408-411 plays a crucial role in platelet aggregation via interactions with the platelet receptor alpha(IIb)beta(3). We describe here the first naturally-occurring fibrinogen point mutation affecting this region and demonstrate its...

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Veröffentlicht in:	Thrombosis and haemostasis 2008-06, Vol.99 (6), p.1008-1012
Hauptverfasser:	Flood, Veronica H, Al-Mondhiry, Hamid A, Rein, Chantelle M, Alexander, Kristine S, Lovely, Rehana S, Shackleton, Kelley M, David, Larry L, Farrell, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Blood Platelets - metabolism DNA Mutational Analysis Female Fibrinogens, Abnormal - genetics Fibrinogens, Abnormal - metabolism Heterozygote Humans Middle Aged Platelet Aggregation - genetics Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Point Mutation Protein Binding
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