Gamma-linoleic acid and ascorbate improves skeletal ossification in offspring of diabetic rats

Maternal diabetes causes a range of complications in offspring, including reduced skeletal ossification. This study examined whether feeding gamma-linoleic acid (GLA) and ascorbate, alone or in combination, to diabetic pregnant rats improves skeletal development in their offspring. In addition, Ca(2...

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Veröffentlicht in:	Pediatric research 2002-05, Vol.51 (5), p.647-652
Hauptverfasser:	BRADDOCK, Rattana, SIMAN, C. Martin, HAMILTON, Katherine, GARLAND, Hugh O, SIBLEY, Colin P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascorbic Acid - analogs & derivatives Ascorbic Acid - therapeutic use Associated diseases and complications Biological and medical sciences Bone and Bones - chemistry Bone and Bones - drug effects Bone and Bones - embryology Calcium - analysis Calcium - blood Diabetes Mellitus, Experimental - blood Diabetes. Impaired glucose tolerance Embryonic and Fetal Development - drug effects Endocrine pancreas. Apud cells (diseases) Endocrinopathies Fatty Acid Desaturases - deficiency Female Fetus - drug effects Fetus - metabolism Glucose Tolerance Test Insulin - analysis Linoleoyl-CoA Desaturase Magnesium - analysis Magnesium - metabolism Male Maternal-Fetal Exchange Medical sciences Mitochondria - metabolism Models, Biological Osteogenesis - drug effects Pregnancy Pregnancy in Diabetics - blood Rats Reactive Oxygen Species Streptozocin
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