The Role of Fines in the Modification of the Fluidization and Dispersion Mechanism Within Dry Powder Inhaler Formulations

Purpose To investigate the role of in situ generated fine excipient particles on the fluidization and aerosolization properties of dry powder inhaler (DPI) formulations. Materials and Methods Carrier based DPI formulations were prepared under low and high shear blending. Powder rheometery was utiliz...

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Veröffentlicht in:	Pharmaceutical research 2008-07, Vol.25 (7), p.1631-1640
Hauptverfasser:	Shur, Jagdeep, Harris, Haggis, Jones, Matthew D., Kaerger, J. Sebastian, Price, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosols Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Bronchodilator Agents - administration & dosage Bronchodilator Agents - chemistry Budesonide - administration & dosage Budesonide - chemistry Chemistry, Pharmaceutical Chromatography, High Pressure Liquid Dispersion Drug Compounding Excipients - chemistry General pharmacology Image Processing, Computer-Assisted Lactose - chemistry Medical Law Medical sciences Microscopy, Electron, Scanning Nebulizers and Vaporizers Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmaceuticals Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Powders - chemistry Research Paper Surface Properties
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