Thiopental inhibits the activation of nuclear factor kappaB

Thiopental is frequently used for the treatment of intracranial hypertension after severe head injury. Its long-term administration increases the incidence of nosocomial infections, which contributes to the high mortality rate of these patients. However, the mechanism of its immunosuppressing effect...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2002-05, Vol.96 (5), p.1202-1213
Hauptverfasser:	Loop, Torsten, Liu, Zhiheng, Humar, Matjaz, Hoetzel, Alexander, Benzing, Albert, Pahl, Heike L, Geiger, Klaus K, J Pannen, Benedikt H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotransformation - drug effects Blotting, Western Cytokines - metabolism Electrophoresis Genes, Reporter - genetics Humans Hypnotics and Sedatives - pharmacology Indicators and Reagents Jurkat Cells Lymphocyte Activation - drug effects Monocytes - drug effects Monocytes - metabolism NF-kappa B - antagonists & inhibitors T-Lymphocytes - drug effects T-Lymphocytes - metabolism Thiopental - pharmacology
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