Bivalent inhibition of β-tryptase: Distance scan of neighboring subunits by dibasic inhibitors

Based on bifunctional diketopiperazines as templates and m-aminomethyl-phenylalanine as arginine mimetic, we have synthesized a new class of structurally related dibasic tryptase inhibitors with systematically increasing spacer length. These compounds were used to scan the distance between the activ...

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