Reductions in qEEG slowing over 1 year and after treatment with Cerebrolysin in patients with moderate–severe traumatic brain injury
Changes in quantitative EEG (qEEG) recordings over a 1-year period and the effects of Cerebrolysin (Cere) on qEEG slowing and cognitive performance were investigated in postacute moderate–severe traumatic brain injury (TBI) patients. Time-related changes in qEEG activity frequency bands (increases o...
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| Veröffentlicht in: | Journal of Neural Transmission 2008-05, Vol.115 (5), p.683-692 |
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| container_title | Journal of Neural Transmission |
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| creator | Álvarez, X. Antón Sampedro, Carolina Figueroa, Jesús Tellado, Iván González, Andrés García-Fantini, Manuel Cacabelos, Ramón Muresanu, Dafin Moessler, Herbert |
| description | Changes in quantitative EEG (qEEG) recordings over a 1-year period and the effects of Cerebrolysin (Cere) on qEEG slowing and cognitive performance were investigated in postacute moderate–severe traumatic brain injury (TBI) patients. Time-related changes in qEEG activity frequency bands (increases of alpha and beta, and reductions of theta and delta relative power) and in qEEG slowing (reduction of EEG power ratio) were statistically significant in patients with a disease progress of less than 2 years at baseline, but not in those patients having a longer disease progress time. Slowing of qEEG activity was also found to be significantly reduced in TBI patients after 1 month of treatment with Cere and 3 months later. Therefore, Cere seems to accelerate the time-related reduction of qEEG slowing occurring in untreated patients. The decrease of qEEG slowing induced by Cere correlated with the improvement of attention and working memory. Results of this exploratory study suggest that Cere might improve the functional recovery after brain injury and encourage the conduction of further controlled clinical trials. |
| doi_str_mv | 10.1007/s00702-008-0024-9 |
| format | Article |
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Antón ; Sampedro, Carolina ; Figueroa, Jesús ; Tellado, Iván ; González, Andrés ; García-Fantini, Manuel ; Cacabelos, Ramón ; Muresanu, Dafin ; Moessler, Herbert</creator><creatorcontrib>Álvarez, X. Antón ; Sampedro, Carolina ; Figueroa, Jesús ; Tellado, Iván ; González, Andrés ; García-Fantini, Manuel ; Cacabelos, Ramón ; Muresanu, Dafin ; Moessler, Herbert</creatorcontrib><description>Changes in quantitative EEG (qEEG) recordings over a 1-year period and the effects of Cerebrolysin (Cere) on qEEG slowing and cognitive performance were investigated in postacute moderate–severe traumatic brain injury (TBI) patients. Time-related changes in qEEG activity frequency bands (increases of alpha and beta, and reductions of theta and delta relative power) and in qEEG slowing (reduction of EEG power ratio) were statistically significant in patients with a disease progress of less than 2 years at baseline, but not in those patients having a longer disease progress time. Slowing of qEEG activity was also found to be significantly reduced in TBI patients after 1 month of treatment with Cere and 3 months later. Therefore, Cere seems to accelerate the time-related reduction of qEEG slowing occurring in untreated patients. The decrease of qEEG slowing induced by Cere correlated with the improvement of attention and working memory. 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Antón</creatorcontrib><creatorcontrib>Sampedro, Carolina</creatorcontrib><creatorcontrib>Figueroa, Jesús</creatorcontrib><creatorcontrib>Tellado, Iván</creatorcontrib><creatorcontrib>González, Andrés</creatorcontrib><creatorcontrib>García-Fantini, Manuel</creatorcontrib><creatorcontrib>Cacabelos, Ramón</creatorcontrib><creatorcontrib>Muresanu, Dafin</creatorcontrib><creatorcontrib>Moessler, Herbert</creatorcontrib><title>Reductions in qEEG slowing over 1 year and after treatment with Cerebrolysin in patients with moderate–severe traumatic brain injury</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm</addtitle><addtitle>J Neural Transm (Vienna)</addtitle><description>Changes in quantitative EEG (qEEG) recordings over a 1-year period and the effects of Cerebrolysin (Cere) on qEEG slowing and cognitive performance were investigated in postacute moderate–severe traumatic brain injury (TBI) patients. 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Results of this exploratory study suggest that Cere might improve the functional recovery after brain injury and encourage the conduction of further controlled clinical trials.</description><subject>Adult</subject><subject>Amino Acids - therapeutic use</subject><subject>Basic Neurosciences</subject><subject>Brain Injuries - drug therapy</subject><subject>Brain Injuries - physiopathology</subject><subject>Brain Mapping</subject><subject>Cognition - drug effects</subject><subject>Electrocardiography - methods</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genetics and Immunology - Original Article</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Neuropsychological Tests</subject><subject>Neurosciences</subject><subject>Psychiatry</subject><subject>Time Factors</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9qFDEUxoModq0-gDcSvPBu7Ekyk2QuZVmrUBCKXodMcqbOMn-2Scayd975AH2BPksfpU9i1lkoCCIkOZDz-75w8hHymsF7BqDOYj6AFwA6b14W9ROyYqWoClZK8ZSsQAAUdSXLE_Iixi0AMKb0c3LCNFeiEmpFfl2in13qpjHSbqTXm805jf10041XdPqBgbL7uz3aQO3oqW1TvkkBbRpwTPSmS9_pGgM2Yer3Mevz2tnU5WZcusPkMdiEDz9vI2Y_zHI7D5lxtAn2j2Q7h_1L8qy1fcRXx3pKvn3cfF1_Ki6-nH9ef7goXAmQChSO6YZbofPQkqP0DqRUlZTIqrbxVkMDJfOtKyuvK9mg1ahKdE6jtsKLU_Ju8d2F6XrGmMzQRYd9b0ec5mgUk4JrUP8FOShdCSkz-PYvcDvNYcxDGJ5_u6x1fYDYArkwxRiwNbvQDTbsDQNzyNIsWZo8ljlkaeqseXM0npsB_aPiGF4G-ALE3BqvMDy-_G_X3ymUrVg</recordid><startdate>20080501</startdate><enddate>20080501</enddate><creator>Álvarez, X. 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Antón ; Sampedro, Carolina ; Figueroa, Jesús ; Tellado, Iván ; González, Andrés ; García-Fantini, Manuel ; Cacabelos, Ramón ; Muresanu, Dafin ; Moessler, Herbert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-e3c18b2a3800862e6dc0667566e15fbda80b041dfc45d856bea8e74ecc8e8a3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Amino Acids - therapeutic use</topic><topic>Basic Neurosciences</topic><topic>Brain Injuries - drug therapy</topic><topic>Brain Injuries - physiopathology</topic><topic>Brain Mapping</topic><topic>Cognition - drug effects</topic><topic>Electrocardiography - methods</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genetics and Immunology - Original Article</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Neuropsychological Tests</topic><topic>Neurosciences</topic><topic>Psychiatry</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Álvarez, X. 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Antón</au><au>Sampedro, Carolina</au><au>Figueroa, Jesús</au><au>Tellado, Iván</au><au>González, Andrés</au><au>García-Fantini, Manuel</au><au>Cacabelos, Ramón</au><au>Muresanu, Dafin</au><au>Moessler, Herbert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reductions in qEEG slowing over 1 year and after treatment with Cerebrolysin in patients with moderate–severe traumatic brain injury</atitle><jtitle>Journal of Neural Transmission</jtitle><stitle>J Neural Transm</stitle><addtitle>J Neural Transm (Vienna)</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>115</volume><issue>5</issue><spage>683</spage><epage>692</epage><pages>683-692</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTRF3</coden><abstract>Changes in quantitative EEG (qEEG) recordings over a 1-year period and the effects of Cerebrolysin (Cere) on qEEG slowing and cognitive performance were investigated in postacute moderate–severe traumatic brain injury (TBI) patients. Time-related changes in qEEG activity frequency bands (increases of alpha and beta, and reductions of theta and delta relative power) and in qEEG slowing (reduction of EEG power ratio) were statistically significant in patients with a disease progress of less than 2 years at baseline, but not in those patients having a longer disease progress time. Slowing of qEEG activity was also found to be significantly reduced in TBI patients after 1 month of treatment with Cere and 3 months later. Therefore, Cere seems to accelerate the time-related reduction of qEEG slowing occurring in untreated patients. The decrease of qEEG slowing induced by Cere correlated with the improvement of attention and working memory. 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| subjects | Adult Amino Acids - therapeutic use Basic Neurosciences Brain Injuries - drug therapy Brain Injuries - physiopathology Brain Mapping Cognition - drug effects Electrocardiography - methods Electroencephalography Female Follow-Up Studies Genetics and Immunology - Original Article Humans Male Medicine Medicine & Public Health Neurology Neuroprotective Agents - therapeutic use Neuropsychological Tests Neurosciences Psychiatry Time Factors |
| title | Reductions in qEEG slowing over 1 year and after treatment with Cerebrolysin in patients with moderate–severe traumatic brain injury |
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