Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients
The aim of this study was to investigate the relationships between insulin resistance and regional abdominal fat area, body mass index (BMI), and serum lipid profile in nonobese Japanese type 2 diabetic patients. A total of 63 nonobese Japanese type 2 diabetic patients aged 45 to 83 years were exami...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 2002-05, Vol.51 (5), p.544-548 |
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| creator | Taniguchi, Ataru Nakai, Yoshikatsu Sakai, Masahiko Yoshii, Satoru Hamanaka, Daizaburo Hatae, Yasuhiko Kawata, Mayumi Yamanouchi, Kazufumi Okumura, Takahide Doi, Kentaro Tokuyama, Kumpei Nagasaka, Shoichiro Fukushima, Mitsuo |
| description | The aim of this study was to investigate the relationships between insulin resistance and regional abdominal fat area, body mass index (BMI), and serum lipid profile in nonobese Japanese type 2 diabetic patients. A total of 63 nonobese Japanese type 2 diabetic patients aged 45 to 83 years were examined. The duration of diabetes was 8.4 [plusmn] 0.8 years. BMI, glycosylated hemoglobin (HbA
1c) levels, and fasting concentrations of plasma glucose, serum lipids (total cholesterol, high-density lipoprotein [HDL] cholesterol, and triglycerides), and serum insulin were measured. The low-density lipoprotein (LDL) cholesterol level was calculated using the Friedewald formula (LDL cholesterol = total cholesterol [minus ] HDL cholesterol [minus ] 1/5 triglycerides). Insulin resistance was estimated by the homeostasis model assessment (HOMA-IR). Computed tomography (CT) was used to measure cross-sectional abdominal subcutaneous and visceral fat areas in all the patients. Adipose tissue areas were determined at the umbilical level. Subcutaneous and visceral abdominal fat areas were 136.5 [plusmn] 6.0 and 86.0 [plusmn] 4.1 cm
2, respectively. Univariate regression analysis showed that insulin resistance was positively correlated with subcutaneous (
r = .544,
P [lt ] .001) and visceral (
r = .408,
P = .001) fat areas, BMI (
r = .324,
P = .009), HbA
1c (
r = .254,
P = .001), serum triglycerides (
r = .419,
P [lt ] .001), and serum LDL cholesterol (
r = .290,
P = .019) levels and was negatively correlated with serum HDL cholesterol level (
r = .254,
P = .041). Multiple regression analyses showed that insulin resistance was independently predicted by the areas of subcutaneous (F = 6.76,
P [lt ] .001) and visceral (F = 4.61,
P [lt ] .001) abdominal fat and serum triglycerides (F = 8.88,
P [lt ] .001) level, which explained 36.9% of the variability of insulin resistance. Moreover, the present study demonstrated that whereas BMI was positively correlated with visceral (
r = .510,
P [lt ] .001) and subcutaneous (
r = .553,
P [lt ] .001) fat areas, serum triglyceride level was positively associated with visceral (
r = .302,
P = .015), but not with subcutaneous (
r = .222,
P = .074) fat area. From these results, it can be suggested that (1) both subcutaneous and visceral abdominal fat areas are independently associated with insulin resistance and (2) visceral fat area, but not the subcutaneous one, is associated with serum triglyceride levels in our nonobese Japanese type 2 diab |
| doi_str_mv | 10.1053/meta.2002.31984 |
| format | Article |
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1c) levels, and fasting concentrations of plasma glucose, serum lipids (total cholesterol, high-density lipoprotein [HDL] cholesterol, and triglycerides), and serum insulin were measured. The low-density lipoprotein (LDL) cholesterol level was calculated using the Friedewald formula (LDL cholesterol = total cholesterol [minus ] HDL cholesterol [minus ] 1/5 triglycerides). Insulin resistance was estimated by the homeostasis model assessment (HOMA-IR). Computed tomography (CT) was used to measure cross-sectional abdominal subcutaneous and visceral fat areas in all the patients. Adipose tissue areas were determined at the umbilical level. Subcutaneous and visceral abdominal fat areas were 136.5 [plusmn] 6.0 and 86.0 [plusmn] 4.1 cm
2, respectively. Univariate regression analysis showed that insulin resistance was positively correlated with subcutaneous (
r = .544,
P [lt ] .001) and visceral (
r = .408,
P = .001) fat areas, BMI (
r = .324,
P = .009), HbA
1c (
r = .254,
P = .001), serum triglycerides (
r = .419,
P [lt ] .001), and serum LDL cholesterol (
r = .290,
P = .019) levels and was negatively correlated with serum HDL cholesterol level (
r = .254,
P = .041). Multiple regression analyses showed that insulin resistance was independently predicted by the areas of subcutaneous (F = 6.76,
P [lt ] .001) and visceral (F = 4.61,
P [lt ] .001) abdominal fat and serum triglycerides (F = 8.88,
P [lt ] .001) level, which explained 36.9% of the variability of insulin resistance. Moreover, the present study demonstrated that whereas BMI was positively correlated with visceral (
r = .510,
P [lt ] .001) and subcutaneous (
r = .553,
P [lt ] .001) fat areas, serum triglyceride level was positively associated with visceral (
r = .302,
P = .015), but not with subcutaneous (
r = .222,
P = .074) fat area. From these results, it can be suggested that (1) both subcutaneous and visceral abdominal fat areas are independently associated with insulin resistance and (2) visceral fat area, but not the subcutaneous one, is associated with serum triglyceride levels in our nonobese Japanese type 2 diabetic patients.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1053/meta.2002.31984</identifier><identifier>PMID: 11979383</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adipose Tissue ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Blood Glucose - analysis ; Body Composition ; Body Mass Index ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Glycated Hemoglobin A - analysis ; Humans ; Insulin Resistance ; Japan ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Obesity ; Regression Analysis ; Triglycerides - blood</subject><ispartof>Metabolism, clinical and experimental, 2002-05, Vol.51 (5), p.544-548</ispartof><rights>2002</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002, Elsevier Science (USA). All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-398581f71183b316d38d2392c03fac86c9789ad18f641151d0cdd36d70c69f573</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026049502122827$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14156094$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11979383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taniguchi, Ataru</creatorcontrib><creatorcontrib>Nakai, Yoshikatsu</creatorcontrib><creatorcontrib>Sakai, Masahiko</creatorcontrib><creatorcontrib>Yoshii, Satoru</creatorcontrib><creatorcontrib>Hamanaka, Daizaburo</creatorcontrib><creatorcontrib>Hatae, Yasuhiko</creatorcontrib><creatorcontrib>Kawata, Mayumi</creatorcontrib><creatorcontrib>Yamanouchi, Kazufumi</creatorcontrib><creatorcontrib>Okumura, Takahide</creatorcontrib><creatorcontrib>Doi, Kentaro</creatorcontrib><creatorcontrib>Tokuyama, Kumpei</creatorcontrib><creatorcontrib>Nagasaka, Shoichiro</creatorcontrib><creatorcontrib>Fukushima, Mitsuo</creatorcontrib><title>Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>The aim of this study was to investigate the relationships between insulin resistance and regional abdominal fat area, body mass index (BMI), and serum lipid profile in nonobese Japanese type 2 diabetic patients. A total of 63 nonobese Japanese type 2 diabetic patients aged 45 to 83 years were examined. The duration of diabetes was 8.4 [plusmn] 0.8 years. BMI, glycosylated hemoglobin (HbA
1c) levels, and fasting concentrations of plasma glucose, serum lipids (total cholesterol, high-density lipoprotein [HDL] cholesterol, and triglycerides), and serum insulin were measured. The low-density lipoprotein (LDL) cholesterol level was calculated using the Friedewald formula (LDL cholesterol = total cholesterol [minus ] HDL cholesterol [minus ] 1/5 triglycerides). Insulin resistance was estimated by the homeostasis model assessment (HOMA-IR). Computed tomography (CT) was used to measure cross-sectional abdominal subcutaneous and visceral fat areas in all the patients. Adipose tissue areas were determined at the umbilical level. Subcutaneous and visceral abdominal fat areas were 136.5 [plusmn] 6.0 and 86.0 [plusmn] 4.1 cm
2, respectively. Univariate regression analysis showed that insulin resistance was positively correlated with subcutaneous (
r = .544,
P [lt ] .001) and visceral (
r = .408,
P = .001) fat areas, BMI (
r = .324,
P = .009), HbA
1c (
r = .254,
P = .001), serum triglycerides (
r = .419,
P [lt ] .001), and serum LDL cholesterol (
r = .290,
P = .019) levels and was negatively correlated with serum HDL cholesterol level (
r = .254,
P = .041). Multiple regression analyses showed that insulin resistance was independently predicted by the areas of subcutaneous (F = 6.76,
P [lt ] .001) and visceral (F = 4.61,
P [lt ] .001) abdominal fat and serum triglycerides (F = 8.88,
P [lt ] .001) level, which explained 36.9% of the variability of insulin resistance. Moreover, the present study demonstrated that whereas BMI was positively correlated with visceral (
r = .510,
P [lt ] .001) and subcutaneous (
r = .553,
P [lt ] .001) fat areas, serum triglyceride level was positively associated with visceral (
r = .302,
P = .015), but not with subcutaneous (
r = .222,
P = .074) fat area. From these results, it can be suggested that (1) both subcutaneous and visceral abdominal fat areas are independently associated with insulin resistance and (2) visceral fat area, but not the subcutaneous one, is associated with serum triglyceride levels in our nonobese Japanese type 2 diabetic patients.</description><subject>Adipose Tissue</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Japan</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Regression Analysis</subject><subject>Triglycerides - blood</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFvFSEQh4nR2Nfq2Zvhord9hWWXhaNpqtU0MTF6JjyYrRh2WRm2ybv7h8v6XtKTJwbmmx-Tj5A3nO0568X1BMXuW8baveBadc_IjveibZRk7DnZ1XfZsE73F-QS8RdjbBiUfEkuONeDFkrsyJ9vEG0JacafYaFppBke6s1Gan1YEoZypCXRMOMaw1y7GLDY2QG1s6cIeZ1oyeEhHh3k4IFGeISIdYDOaU4HQKBf7GLnrSjHBWhLfbAHKMHRpf4Mc8FX5MVoI8Lr83lFfny8_X5z19x__fT55sN94zqhSyO06hUfB86VOAguvVC-Fbp1TIzWKen0oLT1XI2y47znnjnvhfQDc1KP_SCuyPtT7pLT7xWwmCmggxjremlFM3ApuOpEBa9PoMsJMcNolhwmm4-GM7OJN5t4s4k3_8TXibfn6PUwgX_iz6Yr8O4MWHQ2jrlKDPjEdbyXTG9B-sRVi_AYIBt0VZIDHzK4YnwK_13iL54zoVk</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Taniguchi, Ataru</creator><creator>Nakai, Yoshikatsu</creator><creator>Sakai, Masahiko</creator><creator>Yoshii, Satoru</creator><creator>Hamanaka, Daizaburo</creator><creator>Hatae, Yasuhiko</creator><creator>Kawata, Mayumi</creator><creator>Yamanouchi, Kazufumi</creator><creator>Okumura, Takahide</creator><creator>Doi, Kentaro</creator><creator>Tokuyama, Kumpei</creator><creator>Nagasaka, Shoichiro</creator><creator>Fukushima, Mitsuo</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients</title><author>Taniguchi, Ataru ; Nakai, Yoshikatsu ; Sakai, Masahiko ; Yoshii, Satoru ; Hamanaka, Daizaburo ; Hatae, Yasuhiko ; Kawata, Mayumi ; Yamanouchi, Kazufumi ; Okumura, Takahide ; Doi, Kentaro ; Tokuyama, Kumpei ; Nagasaka, Shoichiro ; Fukushima, Mitsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-398581f71183b316d38d2392c03fac86c9789ad18f641151d0cdd36d70c69f573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adipose Tissue</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Body Composition</topic><topic>Body Mass Index</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Japan</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Regression Analysis</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taniguchi, Ataru</creatorcontrib><creatorcontrib>Nakai, Yoshikatsu</creatorcontrib><creatorcontrib>Sakai, Masahiko</creatorcontrib><creatorcontrib>Yoshii, Satoru</creatorcontrib><creatorcontrib>Hamanaka, Daizaburo</creatorcontrib><creatorcontrib>Hatae, Yasuhiko</creatorcontrib><creatorcontrib>Kawata, Mayumi</creatorcontrib><creatorcontrib>Yamanouchi, Kazufumi</creatorcontrib><creatorcontrib>Okumura, Takahide</creatorcontrib><creatorcontrib>Doi, Kentaro</creatorcontrib><creatorcontrib>Tokuyama, Kumpei</creatorcontrib><creatorcontrib>Nagasaka, Shoichiro</creatorcontrib><creatorcontrib>Fukushima, Mitsuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taniguchi, Ataru</au><au>Nakai, Yoshikatsu</au><au>Sakai, Masahiko</au><au>Yoshii, Satoru</au><au>Hamanaka, Daizaburo</au><au>Hatae, Yasuhiko</au><au>Kawata, Mayumi</au><au>Yamanouchi, Kazufumi</au><au>Okumura, Takahide</au><au>Doi, Kentaro</au><au>Tokuyama, Kumpei</au><au>Nagasaka, Shoichiro</au><au>Fukushima, Mitsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>51</volume><issue>5</issue><spage>544</spage><epage>548</epage><pages>544-548</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>The aim of this study was to investigate the relationships between insulin resistance and regional abdominal fat area, body mass index (BMI), and serum lipid profile in nonobese Japanese type 2 diabetic patients. A total of 63 nonobese Japanese type 2 diabetic patients aged 45 to 83 years were examined. The duration of diabetes was 8.4 [plusmn] 0.8 years. BMI, glycosylated hemoglobin (HbA
1c) levels, and fasting concentrations of plasma glucose, serum lipids (total cholesterol, high-density lipoprotein [HDL] cholesterol, and triglycerides), and serum insulin were measured. The low-density lipoprotein (LDL) cholesterol level was calculated using the Friedewald formula (LDL cholesterol = total cholesterol [minus ] HDL cholesterol [minus ] 1/5 triglycerides). Insulin resistance was estimated by the homeostasis model assessment (HOMA-IR). Computed tomography (CT) was used to measure cross-sectional abdominal subcutaneous and visceral fat areas in all the patients. Adipose tissue areas were determined at the umbilical level. Subcutaneous and visceral abdominal fat areas were 136.5 [plusmn] 6.0 and 86.0 [plusmn] 4.1 cm
2, respectively. Univariate regression analysis showed that insulin resistance was positively correlated with subcutaneous (
r = .544,
P [lt ] .001) and visceral (
r = .408,
P = .001) fat areas, BMI (
r = .324,
P = .009), HbA
1c (
r = .254,
P = .001), serum triglycerides (
r = .419,
P [lt ] .001), and serum LDL cholesterol (
r = .290,
P = .019) levels and was negatively correlated with serum HDL cholesterol level (
r = .254,
P = .041). Multiple regression analyses showed that insulin resistance was independently predicted by the areas of subcutaneous (F = 6.76,
P [lt ] .001) and visceral (F = 4.61,
P [lt ] .001) abdominal fat and serum triglycerides (F = 8.88,
P [lt ] .001) level, which explained 36.9% of the variability of insulin resistance. Moreover, the present study demonstrated that whereas BMI was positively correlated with visceral (
r = .510,
P [lt ] .001) and subcutaneous (
r = .553,
P [lt ] .001) fat areas, serum triglyceride level was positively associated with visceral (
r = .302,
P = .015), but not with subcutaneous (
r = .222,
P = .074) fat area. From these results, it can be suggested that (1) both subcutaneous and visceral abdominal fat areas are independently associated with insulin resistance and (2) visceral fat area, but not the subcutaneous one, is associated with serum triglyceride levels in our nonobese Japanese type 2 diabetic patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11979383</pmid><doi>10.1053/meta.2002.31984</doi><tpages>5</tpages></addata></record> |
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| subjects | Adipose Tissue Aged Aged, 80 and over Biological and medical sciences Blood Glucose - analysis Body Composition Body Mass Index Cholesterol, HDL - blood Cholesterol, LDL - blood Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glycated Hemoglobin A - analysis Humans Insulin Resistance Japan Male Medical sciences Metabolic diseases Middle Aged Obesity Regression Analysis Triglycerides - blood |
| title | Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients |
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