Inhibition of Protein Geranylgeranylation and RhoA/RhoA Kinase Pathway Induces Apoptosis in Human Endothelial Cells

Geranylgeranylation of RhoA small G-protein is essential for its localization to cell membranes and for its biological functions. Many RhoA effects are mediated by its downstream effector RhoA kinase. The role of protein geranylgeranylation and the RhoA pathway in the regulation of endothelial cell...

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Veröffentlicht in:	The Journal of biological chemistry 2002-05, Vol.277 (18), p.15309-15316
Hauptverfasser:	Li, Xianwu, Liu, Li, Tupper, Joan C., Bannerman, Douglas D., Winn, Robert K., Sebti, Said M., Hamilton, Andrew D., Harlan, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - physiology Benzamides - pharmacology Caspase 3 Caspases - metabolism Cell Death - drug effects Cells, Cultured Diterpenes - pharmacology Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Intracellular Signaling Peptides and Proteins Lovastatin - pharmacology Methionine - analogs & derivatives Methionine - pharmacology Polyisoprenyl Phosphates Protein Prenylation Protein-Serine-Threonine Kinases - metabolism rho-Associated Kinases rhoA GTP-Binding Protein - metabolism Umbilical Veins
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