Large-Scale Isolation and Crystallization of Epothilone D From Myxococcus xanthus Cultures

The introduction of the epothilone polyketide synthase (PKS) into Myxococcus xanthus has enabled the heterologous production of epothilone D (1) on a large scale. To isolate this valuable product from the fermentation medium, an economical, scalable, and high-yielding purification process was develo...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2002-04, Vol.65 (4), p.570-572
Hauptverfasser:	ARSLANIAN, Robert L., PARKER, Charles D., WANG, Peter K., MCINTIRE, James R., LAU, Janice, STARKS, Courtney, LICARI, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Carbon Chemistry, Organic - methods Chemotherapic agents Chromatography, High Pressure Liquid Crystallization Epothilones Epoxy Compounds - chemistry Epoxy Compounds - economics Epoxy Compounds - isolation & purification Fundamental and applied biological sciences. Psychology Mass Spectrometry Microbiology Molecular Conformation Multienzyme Complexes - metabolism Myxococcus - chemistry Thiazoles - chemistry Thiazoles - economics Thiazoles - isolation & purification
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