Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome

Aims/hypothesis Variants in the fat-mass and obesity-associated gene (FTO) influence susceptibility to type 2 diabetes via an effect on adiposity/obesity. Given the important role of obesity in the aetiology of both polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus, our aim was to establ...

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Veröffentlicht in:	Diabetologia 2008-07, Vol.51 (7), p.1153-1158
Hauptverfasser:	Barber, T. M, Bennett, A. J, Groves, C. J, Sovio, U, Ruokonen, A, Martikainen, H, Pouta, A, Hartikainen, A.-L, Elliott, P, Lindgren, C. M, Freathy, R. M, Koch, K, Ouwehand, W. H, Karpe, F, Conway, G. S, Wass, J. A. H, Järvelin, M.-R, Franks, S, McCarthy, M. I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - pathology Adult Alpha-Ketoglutarate-Dependent Dioxygenase FTO Androgens Biobanks Biological and medical sciences Case-Control Studies College campuses Consortia Diabetes Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Female genital diseases Finland - epidemiology FTO variants Gene Frequency Genetic Predisposition to Disease - epidemiology Genetic Variation Genotype Genotype & phenotype Gynecology. Andrology. Obstetrics Health services Human Physiology Humans Influence Internal Medicine Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Non tumoral diseases Obesity Obesity - epidemiology Obesity - genetics Obesity - pathology Ovaries Polycystic ovary syndrome Polycystic Ovary Syndrome - epidemiology Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - pathology Proteins - genetics Public health Risk Factors Testosterone Type 2 diabetes mellitus United Kingdom - epidemiology Weight control
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