Inhibition of gastric cancer invasion and metastasis by PLA2G2A, a novel beta-catenin/TCF target gene

Elevated expression of the PLA2G2A phospholipase in gastric cancer (GC) is associated with improved patient survival. To elucidate function and regulation of PLA2G2A in GC, we analyzed a panel of GC cell lines. PLA2G2A was specifically expressed in lines with constitutive Wnt activity, implicating b...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-06, Vol.68 (11), p.4277-4286
Hauptverfasser:	Ganesan, Kumaresan, Ivanova, Tatiana, Wu, Yonghui, Rajasegaran, Vikneswari, Wu, Jeanie, Lee, Ming Hui, Yu, Kun, Rha, Sun Young, Chung, Hyun Cheol, Ylstra, Bauke, Meijer, Gerrit, Lian, Kon Oi, Grabsch, Heike, Tan, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence beta Catenin - genetics Cell Line, Tumor Chromatin Immunoprecipitation Gene Expression Profiling Group II Phospholipases A2 - genetics Humans Neoplasm Invasiveness - genetics Neoplasm Metastasis - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering Stomach Neoplasms - genetics Stomach Neoplasms - pathology TCF Transcription Factors - genetics Wnt Proteins - metabolism
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