Association of plasma homocysteine with restenosis after percutaneous coronary angioplasty
Aims Restenosis after percutaneous coronary angioplasty remains an important limitation of this procedure. This study evaluates whether elevated total plasma homocysteine levels contribute to the development of restenosis after coronary angioplasty. Methods and Results Two hundred and five patients...
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| Veröffentlicht in: | European heart journal 2002-05, Vol.23 (9), p.726-733 |
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| creator | Schnyder, G. Roffi, M. Flammer, Y. Pin, R. Hess, O.M. |
| description | Aims Restenosis after percutaneous coronary angioplasty remains an important limitation of this procedure. This study evaluates whether elevated total plasma homocysteine levels contribute to the development of restenosis after coronary angioplasty. Methods and Results Two hundred and five patients were recruited after successful angioplasty of at least one coronary stenosis (≥50%). End-points were restenosis (≥50%) and a composite of major adverse cardiac events. Of the 205 patients, 183 (89·3%) underwent 6 months angiographic follow-up. Patients with restenosis had significantly higher homocysteine levels than those without (10·9± 3·9μmol.l−1 vs 9·3±3·8μmol.l−1, P |
| doi_str_mv | 10.1053/euhj.2001.2962 |
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This study evaluates whether elevated total plasma homocysteine levels contribute to the development of restenosis after coronary angioplasty. Methods and Results Two hundred and five patients were recruited after successful angioplasty of at least one coronary stenosis (≥50%). End-points were restenosis (≥50%) and a composite of major adverse cardiac events. Of the 205 patients, 183 (89·3%) underwent 6 months angiographic follow-up. Patients with restenosis had significantly higher homocysteine levels than those without (10·9± 3·9μmol.l−1 vs 9·3±3·8μmol.l−1, P<0·01). Homocysteine levels were significantly correlated to follow-up diameter stenosis (r=0·24, P=0·0001), especially in small vessels (<3mm) treated with balloon angioplasty only (r=0·40,P <0·0005). Late lumen loss at follow-up was significantly smaller with homocysteine levels below 9μmol.l−1 (0·62±0·82mm vs 0·90±0·77mm, P<0·01). Restenosis rate (25·3% vs 50·0%,P <0·001) and major adverse cardiac events (15·7% vs 28·4%,P <0·05) were also significantly lower in patients with homocysteine levels below 9μmol.l−1. Multivariate analysis did not weaken these findings. Conclusion Total plasma homocysteine is a strong predictor of restenosis and major adverse cardiac events after coronary angioplasty. Thus, plasma homocysteine appears to be an important cardiovascular risk factor influencing outcome after successful coronary angioplasty.]]></description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1053/euhj.2001.2962</identifier><identifier>PMID: 11977999</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aged ; Angioplasty ; Angioplasty, Balloon, Coronary - adverse effects ; Biological and medical sciences ; Biomarkers - blood ; Coronary Angiography ; Coronary Restenosis - blood ; Coronary Restenosis - etiology ; Coronary Restenosis - mortality ; Coronary Stenosis - complications ; Coronary Stenosis - diagnostic imaging ; Coronary Stenosis - therapy ; Coronary Vessels - surgery ; death ; Diseases of the cardiovascular system ; Endpoint Determination ; Female ; Follow-Up Studies ; homocysteine ; Homocysteine - blood ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; myocardial infarction ; Postoperative Complications - blood ; Postoperative Complications - etiology ; Postoperative Complications - mortality ; Prospective Studies ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Recurrence ; restenosis ; Severity of Illness Index ; Statistics as Topic ; Survival Analysis ; Treatment Outcome</subject><ispartof>European heart journal, 2002-05, Vol.23 (9), p.726-733</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 The European Society of Cardiology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-738590ae569ba93f1fcec5f136d0801b456f757eb65840d591db7e766d5424f03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13668820$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11977999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schnyder, G.</creatorcontrib><creatorcontrib>Roffi, M.</creatorcontrib><creatorcontrib>Flammer, Y.</creatorcontrib><creatorcontrib>Pin, R.</creatorcontrib><creatorcontrib>Hess, O.M.</creatorcontrib><title>Association of plasma homocysteine with restenosis after percutaneous coronary angioplasty</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description><![CDATA[Aims Restenosis after percutaneous coronary angioplasty remains an important limitation of this procedure. This study evaluates whether elevated total plasma homocysteine levels contribute to the development of restenosis after coronary angioplasty. Methods and Results Two hundred and five patients were recruited after successful angioplasty of at least one coronary stenosis (≥50%). End-points were restenosis (≥50%) and a composite of major adverse cardiac events. Of the 205 patients, 183 (89·3%) underwent 6 months angiographic follow-up. Patients with restenosis had significantly higher homocysteine levels than those without (10·9± 3·9μmol.l−1 vs 9·3±3·8μmol.l−1, P<0·01). Homocysteine levels were significantly correlated to follow-up diameter stenosis (r=0·24, P=0·0001), especially in small vessels (<3mm) treated with balloon angioplasty only (r=0·40,P <0·0005). Late lumen loss at follow-up was significantly smaller with homocysteine levels below 9μmol.l−1 (0·62±0·82mm vs 0·90±0·77mm, P<0·01). Restenosis rate (25·3% vs 50·0%,P <0·001) and major adverse cardiac events (15·7% vs 28·4%,P <0·05) were also significantly lower in patients with homocysteine levels below 9μmol.l−1. Multivariate analysis did not weaken these findings. Conclusion Total plasma homocysteine is a strong predictor of restenosis and major adverse cardiac events after coronary angioplasty. Thus, plasma homocysteine appears to be an important cardiovascular risk factor influencing outcome after successful coronary angioplasty.]]></description><subject>Aged</subject><subject>Angioplasty</subject><subject>Angioplasty, Balloon, Coronary - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Coronary Angiography</subject><subject>Coronary Restenosis - blood</subject><subject>Coronary Restenosis - etiology</subject><subject>Coronary Restenosis - mortality</subject><subject>Coronary Stenosis - complications</subject><subject>Coronary Stenosis - diagnostic imaging</subject><subject>Coronary Stenosis - therapy</subject><subject>Coronary Vessels - surgery</subject><subject>death</subject><subject>Diseases of the cardiovascular system</subject><subject>Endpoint Determination</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>myocardial infarction</subject><subject>Postoperative Complications - blood</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - mortality</subject><subject>Prospective Studies</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Recurrence</subject><subject>restenosis</subject><subject>Severity of Illness Index</subject><subject>Statistics as Topic</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUh4MoOqdXj5KL3jqTpkmao4huwkCQKcNLSNPEZbbNTFp0_70tG-70eLzv_fjxAXCF0QQjSu5Mt1pPUoTwJBUsPQIjTNM0ESyjx2CEsKAJY_nyDJzHuEYI5QyzU3CGseBcCDECH_cxeu1U63wDvYWbSsVawZWvvd7G1rjGwB_XrmAw_db46CJUtjUBbkzQXasa47sItQ--UWELVfPp_BDSbi_AiVVVNJf7OQZvT4-Lh1kyf5k-P9zPE02EaBNOciqQMpSJQglisdVGU4sJK1GOcJFRZjnlpmA0z1BJBS4LbjhjJc3SzCIyBre73E3w311fU9YualNVu26SY5YKgbIenOxAHXyMwVi5Ca7uW0uM5GBTDjblYFMONvuH631yV9SmPOB7fT1wswdU1KqyQTXaxQNHevl5OlRMdpzrJf7-31X4kowTTuVs-SHpNH99zxeZXJI_hZCOzw</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Schnyder, G.</creator><creator>Roffi, M.</creator><creator>Flammer, Y.</creator><creator>Pin, R.</creator><creator>Hess, O.M.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Association of plasma homocysteine with restenosis after percutaneous coronary angioplasty</title><author>Schnyder, G. ; Roffi, M. ; Flammer, Y. ; Pin, R. ; Hess, O.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-738590ae569ba93f1fcec5f136d0801b456f757eb65840d591db7e766d5424f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Angioplasty</topic><topic>Angioplasty, Balloon, Coronary - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Coronary Angiography</topic><topic>Coronary Restenosis - blood</topic><topic>Coronary Restenosis - etiology</topic><topic>Coronary Restenosis - mortality</topic><topic>Coronary Stenosis - complications</topic><topic>Coronary Stenosis - diagnostic imaging</topic><topic>Coronary Stenosis - therapy</topic><topic>Coronary Vessels - surgery</topic><topic>death</topic><topic>Diseases of the cardiovascular system</topic><topic>Endpoint Determination</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>myocardial infarction</topic><topic>Postoperative Complications - blood</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - mortality</topic><topic>Prospective Studies</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Recurrence</topic><topic>restenosis</topic><topic>Severity of Illness Index</topic><topic>Statistics as Topic</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schnyder, G.</creatorcontrib><creatorcontrib>Roffi, M.</creatorcontrib><creatorcontrib>Flammer, Y.</creatorcontrib><creatorcontrib>Pin, R.</creatorcontrib><creatorcontrib>Hess, O.M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schnyder, G.</au><au>Roffi, M.</au><au>Flammer, Y.</au><au>Pin, R.</au><au>Hess, O.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of plasma homocysteine with restenosis after percutaneous coronary angioplasty</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>23</volume><issue>9</issue><spage>726</spage><epage>733</epage><pages>726-733</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract><![CDATA[Aims Restenosis after percutaneous coronary angioplasty remains an important limitation of this procedure. This study evaluates whether elevated total plasma homocysteine levels contribute to the development of restenosis after coronary angioplasty. Methods and Results Two hundred and five patients were recruited after successful angioplasty of at least one coronary stenosis (≥50%). End-points were restenosis (≥50%) and a composite of major adverse cardiac events. Of the 205 patients, 183 (89·3%) underwent 6 months angiographic follow-up. Patients with restenosis had significantly higher homocysteine levels than those without (10·9± 3·9μmol.l−1 vs 9·3±3·8μmol.l−1, P<0·01). Homocysteine levels were significantly correlated to follow-up diameter stenosis (r=0·24, P=0·0001), especially in small vessels (<3mm) treated with balloon angioplasty only (r=0·40,P <0·0005). Late lumen loss at follow-up was significantly smaller with homocysteine levels below 9μmol.l−1 (0·62±0·82mm vs 0·90±0·77mm, P<0·01). Restenosis rate (25·3% vs 50·0%,P <0·001) and major adverse cardiac events (15·7% vs 28·4%,P <0·05) were also significantly lower in patients with homocysteine levels below 9μmol.l−1. Multivariate analysis did not weaken these findings. Conclusion Total plasma homocysteine is a strong predictor of restenosis and major adverse cardiac events after coronary angioplasty. Thus, plasma homocysteine appears to be an important cardiovascular risk factor influencing outcome after successful coronary angioplasty.]]></abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11977999</pmid><doi>10.1053/euhj.2001.2962</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Angioplasty Angioplasty, Balloon, Coronary - adverse effects Biological and medical sciences Biomarkers - blood Coronary Angiography Coronary Restenosis - blood Coronary Restenosis - etiology Coronary Restenosis - mortality Coronary Stenosis - complications Coronary Stenosis - diagnostic imaging Coronary Stenosis - therapy Coronary Vessels - surgery death Diseases of the cardiovascular system Endpoint Determination Female Follow-Up Studies homocysteine Homocysteine - blood Humans Incidence Male Medical sciences Middle Aged myocardial infarction Postoperative Complications - blood Postoperative Complications - etiology Postoperative Complications - mortality Prospective Studies Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Recurrence restenosis Severity of Illness Index Statistics as Topic Survival Analysis Treatment Outcome |
| title | Association of plasma homocysteine with restenosis after percutaneous coronary angioplasty |
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