Low frequency of clonotypic Ig and T‐cell receptor gene rearrangements in t(4;11) infant acute lymphoblastic leukaemia and its implication for the detection of minimal residual disease

Infant t(4;11) acute lymphoblastic leukaemia (ALL) is a rare but cytogenetically well defined subgroup of immature B‐cell precursor (BCP) ALL. To date, the configuration of their antigen receptor genes has not been studied in a large group of patients so far. In this study on 27 t(4;11) infant ALL,...

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Veröffentlicht in:	British journal of haematology 2002-05, Vol.117 (2), p.315-321
Hauptverfasser:	Peham, Martina, Panzer, Simon, Fasching, Karin, Haas, Oskar A., Fischer, Susanna, Marschalek, Rolf, Gadner, Helmut, Panzer‐Grümayer, E. Renate
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 4 Gene Rearrangement, T-Lymphocyte Hematologic and hematopoietic diseases Hematology Humans immunoglobulin Infant infant ALL Infant, Newborn Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences minimal residual disease (MRD) Myeloid-Lymphoid Leukemia Protein Neoplasm, Residual - diagnosis Oncogene Proteins, Fusion - genetics Polymerase Chain Reaction - methods Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology Sensitivity and Specificity t(4 11) TCR gene rearrangement Translocation, Genetic
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