Changing the adenovirus fiber for retaining gene delivery efficacy in the presence of neutralizing antibodies

Prior infection has primed most adult humans for a rapid neutralizing antibody (NAb) response when re-exposed to adenovirus. NAb induction can severely limit the efficacy of systemic re-administration of adenoviral gene therapy. We hypothesized that changing the fiber knob could overcome NAb. Immune...

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Veröffentlicht in:	Gene therapy 2008-06, Vol.15 (12), p.921-929
Hauptverfasser:	Särkioja, M, Pesonen, S, Raki, M, Hakkarainen, T, Salo, J, Ahonen, M T, Kanerva, A, Hemminki, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibodies Antibodies, Viral - immunology Antigens, Viral - genetics Antigens, Viral - immunology Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Cancer Capsid Proteins - genetics Carcinoma, Non-Small-Cell Lung - therapy Care and treatment Cell Biology Development and progression Explants Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic aspects Genetic Engineering Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - genetics Health aspects Health. Pharmaceutical industry Human Genetics Humans Immunology Industrial applications and implications. Economical aspects Infections Intravenous administration Lung - immunology Lung - virology Lung cancer Lung Neoplasms - immunology Lung Neoplasms - therapy Medical sciences Mice Mice, Inbred ICR Mice, Nude Nanotechnology original-article Patient outcomes Rodents Spleen Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumors Viral antibodies Viruses Xenograft Model Antitumor Assays Xenografts
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