Low DNA HTLV-2 proviral load among women in São Paulo City
HTLV-2 infections are almost always asymptomatic, and diseases associated with the infection are rarely reported. Little information is available on the relationship between HTLV-2 proviral load and gender or expression of disease, especially among patients with HIV-1 co-infection. We studied 77 HTL...
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| Veröffentlicht in: | Virus research 2008-07, Vol.135 (1), p.22-25 |
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| creator | Montanheiro, Patrícia Olah, Ingrid Fukumori, Ligia M.I. Smid, Jerusa Oliveira, Augusto César Penalva de Kanzaki, Luis I.B. Fonseca, Luiz Augusto M. Duarte, Alberto J.S. Casseb, Jorge |
| description | HTLV-2 infections are almost always asymptomatic, and diseases associated with the infection are rarely reported. Little information is available on the relationship between HTLV-2 proviral load and gender or expression of disease, especially among patients with HIV-1 co-infection.
We studied 77 HTLV-2-infected subjects followed in our clinic for the last 9 years; 53 (69%) of them were co-infected with HIV-1. HTLV-2 DNA proviral load (PVL) was measured by real time PCR, a test with a sensitivity of 10 in 10
4 PBMCs.
Six of 53
HTLV-2/HIV-1 cases had a myelopathy (all of them had undetectable PVL of HTLV-2). Only 3 of 35 women (2 out of 3 co-infected with HIV) had a detectable PVL, whereas 10 of 42 men had a detectable PVL. Regardless of their HIV status women had significantly lower PVL than men (10 vs. 43 copies/10
4 PBMCs,
p
<
0.05).
We noticed the occurrence of myelopathy in HTLV-2/HIV-1 co-infected patients, with undetectable HTLV-2 viral load. There was a sex difference in viral load for HTLV-2, what may be the result in mode of transmission or acquisition of the virus. |
| doi_str_mv | 10.1016/j.virusres.2008.01.015 |
| format | Article |
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We studied 77 HTLV-2-infected subjects followed in our clinic for the last 9 years; 53 (69%) of them were co-infected with HIV-1. HTLV-2 DNA proviral load (PVL) was measured by real time PCR, a test with a sensitivity of 10 in 10
4 PBMCs.
Six of 53
HTLV-2/HIV-1 cases had a myelopathy (all of them had undetectable PVL of HTLV-2). Only 3 of 35 women (2 out of 3 co-infected with HIV) had a detectable PVL, whereas 10 of 42 men had a detectable PVL. Regardless of their HIV status women had significantly lower PVL than men (10 vs. 43 copies/10
4 PBMCs,
p
<
0.05).
We noticed the occurrence of myelopathy in HTLV-2/HIV-1 co-infected patients, with undetectable HTLV-2 viral load. There was a sex difference in viral load for HTLV-2, what may be the result in mode of transmission or acquisition of the virus.</description><identifier>ISSN: 0168-1702</identifier><identifier>EISSN: 1872-7492</identifier><identifier>DOI: 10.1016/j.virusres.2008.01.015</identifier><identifier>PMID: 18343520</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Brazil - epidemiology ; DNA proviral load ; Female ; Follow-Up Studies ; HIV Infections - complications ; HIV Infections - virology ; HIV-1 ; HIV-1 - physiology ; HTLV-2 ; HTLV-II Infections - complications ; HTLV-II Infections - epidemiology ; HTLV-II Infections - immunology ; HTLV-II Infections - virology ; Human immunodeficiency virus 1 ; Human T-lymphotropic virus 2 ; Human T-lymphotropic virus 2 - genetics ; Human T-lymphotropic virus 2 - isolation & purification ; Humans ; IDU ; Lymphocyte Count ; Male ; Proviruses - genetics ; Proviruses - isolation & purification ; Sex Factors ; Transmission ; Viral Load</subject><ispartof>Virus research, 2008-07, Vol.135 (1), p.22-25</ispartof><rights>2008 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-a08613f30ca9c1da6b6e046a75bc75bf77856e800f24c3f0f673246db7c732d83</citedby><cites>FETCH-LOGICAL-c397t-a08613f30ca9c1da6b6e046a75bc75bf77856e800f24c3f0f673246db7c732d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.virusres.2008.01.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18343520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montanheiro, Patrícia</creatorcontrib><creatorcontrib>Olah, Ingrid</creatorcontrib><creatorcontrib>Fukumori, Ligia M.I.</creatorcontrib><creatorcontrib>Smid, Jerusa</creatorcontrib><creatorcontrib>Oliveira, Augusto César Penalva de</creatorcontrib><creatorcontrib>Kanzaki, Luis I.B.</creatorcontrib><creatorcontrib>Fonseca, Luiz Augusto M.</creatorcontrib><creatorcontrib>Duarte, Alberto J.S.</creatorcontrib><creatorcontrib>Casseb, Jorge</creatorcontrib><title>Low DNA HTLV-2 proviral load among women in São Paulo City</title><title>Virus research</title><addtitle>Virus Res</addtitle><description>HTLV-2 infections are almost always asymptomatic, and diseases associated with the infection are rarely reported. Little information is available on the relationship between HTLV-2 proviral load and gender or expression of disease, especially among patients with HIV-1 co-infection.
We studied 77 HTLV-2-infected subjects followed in our clinic for the last 9 years; 53 (69%) of them were co-infected with HIV-1. HTLV-2 DNA proviral load (PVL) was measured by real time PCR, a test with a sensitivity of 10 in 10
4 PBMCs.
Six of 53
HTLV-2/HIV-1 cases had a myelopathy (all of them had undetectable PVL of HTLV-2). Only 3 of 35 women (2 out of 3 co-infected with HIV) had a detectable PVL, whereas 10 of 42 men had a detectable PVL. Regardless of their HIV status women had significantly lower PVL than men (10 vs. 43 copies/10
4 PBMCs,
p
<
0.05).
We noticed the occurrence of myelopathy in HTLV-2/HIV-1 co-infected patients, with undetectable HTLV-2 viral load. There was a sex difference in viral load for HTLV-2, what may be the result in mode of transmission or acquisition of the virus.</description><subject>Adult</subject><subject>Brazil - epidemiology</subject><subject>DNA proviral load</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - virology</subject><subject>HIV-1</subject><subject>HIV-1 - physiology</subject><subject>HTLV-2</subject><subject>HTLV-II Infections - complications</subject><subject>HTLV-II Infections - epidemiology</subject><subject>HTLV-II Infections - immunology</subject><subject>HTLV-II Infections - virology</subject><subject>Human immunodeficiency virus 1</subject><subject>Human T-lymphotropic virus 2</subject><subject>Human T-lymphotropic virus 2 - genetics</subject><subject>Human T-lymphotropic virus 2 - isolation & purification</subject><subject>Humans</subject><subject>IDU</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Proviruses - genetics</subject><subject>Proviruses - isolation & purification</subject><subject>Sex Factors</subject><subject>Transmission</subject><subject>Viral Load</subject><issn>0168-1702</issn><issn>1872-7492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1OAjEQgBujEfx5BdKTt8Vpu9uWeJHgDyZETUSvTel2TcnuFrcshOfxUXwxS8B4JJnJzOGbn3wI9Qj0CRB-Pe-vXNOGxoY-BZB9IDGyI9QlUtBEpAN6jLoRlAkRQDvoLIQ5AHAm-CnqEMlSllHoopuJX-O75yEeTycfCcWLxsfFusSl1znWla8_8dpXtsauxm8_3x6_6rb0eOSWmwt0Uugy2Mt9PUfvD_fT0TiZvDw-jYaTxLCBWCYaJCesYGD0wJBc8xm3kHItspmJWQghM24lQEFTwwoouGA05flMmNjkkp2jq93e-NxXa8NSVS4YW5a6tr4NShBOJRHkIEhBSGBSRJDvQNP4ECUWatG4SjcbRUBt_aq5-vOrtn4VkBhZHOztL7Szyub_Y3uhEbjdATYKWTnbqGCcrY3NXWPNUuXeHbrxC0jNjaQ</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Montanheiro, Patrícia</creator><creator>Olah, Ingrid</creator><creator>Fukumori, Ligia M.I.</creator><creator>Smid, Jerusa</creator><creator>Oliveira, Augusto César Penalva de</creator><creator>Kanzaki, Luis I.B.</creator><creator>Fonseca, Luiz Augusto M.</creator><creator>Duarte, Alberto J.S.</creator><creator>Casseb, Jorge</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Low DNA HTLV-2 proviral load among women in São Paulo City</title><author>Montanheiro, Patrícia ; Olah, Ingrid ; Fukumori, Ligia M.I. ; Smid, Jerusa ; Oliveira, Augusto César Penalva de ; Kanzaki, Luis I.B. ; Fonseca, Luiz Augusto M. ; Duarte, Alberto J.S. ; Casseb, Jorge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-a08613f30ca9c1da6b6e046a75bc75bf77856e800f24c3f0f673246db7c732d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Brazil - epidemiology</topic><topic>DNA proviral load</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - virology</topic><topic>HIV-1</topic><topic>HIV-1 - physiology</topic><topic>HTLV-2</topic><topic>HTLV-II Infections - complications</topic><topic>HTLV-II Infections - epidemiology</topic><topic>HTLV-II Infections - immunology</topic><topic>HTLV-II Infections - virology</topic><topic>Human immunodeficiency virus 1</topic><topic>Human T-lymphotropic virus 2</topic><topic>Human T-lymphotropic virus 2 - genetics</topic><topic>Human T-lymphotropic virus 2 - isolation & purification</topic><topic>Humans</topic><topic>IDU</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Proviruses - genetics</topic><topic>Proviruses - isolation & purification</topic><topic>Sex Factors</topic><topic>Transmission</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montanheiro, Patrícia</creatorcontrib><creatorcontrib>Olah, Ingrid</creatorcontrib><creatorcontrib>Fukumori, Ligia M.I.</creatorcontrib><creatorcontrib>Smid, Jerusa</creatorcontrib><creatorcontrib>Oliveira, Augusto César Penalva de</creatorcontrib><creatorcontrib>Kanzaki, Luis I.B.</creatorcontrib><creatorcontrib>Fonseca, Luiz Augusto M.</creatorcontrib><creatorcontrib>Duarte, Alberto J.S.</creatorcontrib><creatorcontrib>Casseb, Jorge</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virus research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montanheiro, Patrícia</au><au>Olah, Ingrid</au><au>Fukumori, Ligia M.I.</au><au>Smid, Jerusa</au><au>Oliveira, Augusto César Penalva de</au><au>Kanzaki, Luis I.B.</au><au>Fonseca, Luiz Augusto M.</au><au>Duarte, Alberto J.S.</au><au>Casseb, Jorge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low DNA HTLV-2 proviral load among women in São Paulo City</atitle><jtitle>Virus research</jtitle><addtitle>Virus Res</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>135</volume><issue>1</issue><spage>22</spage><epage>25</epage><pages>22-25</pages><issn>0168-1702</issn><eissn>1872-7492</eissn><abstract>HTLV-2 infections are almost always asymptomatic, and diseases associated with the infection are rarely reported. Little information is available on the relationship between HTLV-2 proviral load and gender or expression of disease, especially among patients with HIV-1 co-infection.
We studied 77 HTLV-2-infected subjects followed in our clinic for the last 9 years; 53 (69%) of them were co-infected with HIV-1. HTLV-2 DNA proviral load (PVL) was measured by real time PCR, a test with a sensitivity of 10 in 10
4 PBMCs.
Six of 53
HTLV-2/HIV-1 cases had a myelopathy (all of them had undetectable PVL of HTLV-2). Only 3 of 35 women (2 out of 3 co-infected with HIV) had a detectable PVL, whereas 10 of 42 men had a detectable PVL. Regardless of their HIV status women had significantly lower PVL than men (10 vs. 43 copies/10
4 PBMCs,
p
<
0.05).
We noticed the occurrence of myelopathy in HTLV-2/HIV-1 co-infected patients, with undetectable HTLV-2 viral load. There was a sex difference in viral load for HTLV-2, what may be the result in mode of transmission or acquisition of the virus.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>18343520</pmid><doi>10.1016/j.virusres.2008.01.015</doi><tpages>4</tpages></addata></record> |
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| ispartof | Virus research, 2008-07, Vol.135 (1), p.22-25 |
| issn | 0168-1702 1872-7492 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Brazil - epidemiology DNA proviral load Female Follow-Up Studies HIV Infections - complications HIV Infections - virology HIV-1 HIV-1 - physiology HTLV-2 HTLV-II Infections - complications HTLV-II Infections - epidemiology HTLV-II Infections - immunology HTLV-II Infections - virology Human immunodeficiency virus 1 Human T-lymphotropic virus 2 Human T-lymphotropic virus 2 - genetics Human T-lymphotropic virus 2 - isolation & purification Humans IDU Lymphocyte Count Male Proviruses - genetics Proviruses - isolation & purification Sex Factors Transmission Viral Load |
| title | Low DNA HTLV-2 proviral load among women in São Paulo City |
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