Ossifying fibromyxoid tumor of soft parts.: Cytogenetic findings
Ossifying fibromyxoid tumor (OFMT) of soft parts is a recently described, rare but morphologically distinctive soft tissue tumor. The histogenesis of this lesion remains uncertain, although several immunohistochemical and ultrastructural features suggest that it is an unusual neural tumor, possibly...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 2002-03, Vol.133 (2), p.124-128 |
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| creator | Nishio, Jun Iwasaki, Hiroshi Ohjimi, Yuko Ishiguro, Masako Isayama, Teruto Naito, Masatoshi Okabayashi, Hiroshi Kaneko, Yasuhiko Kikuchi, Masahiro |
| description | Ossifying fibromyxoid tumor (OFMT) of soft parts is a recently described, rare but morphologically distinctive soft tissue tumor. The histogenesis of this lesion remains uncertain, although several immunohistochemical and ultrastructural features suggest that it is an unusual neural tumor, possibly of Schwann cell origin. We report here a case of a malignant variant of OFMT that occurred in the foot of a 52-year-old man. The karyotype of a pulmonary metastasis exhibited the following complex numeric and structural aberrations:72∼74,XXY,−5
[7],+6
[5],+del(8)(p21),del(9)(p22),+10,der(11)t(3;11)(p21;p15),del(12) (q13),der(13)t(5;13)(q13;q34),+18
[6],+19,+20,−22
[5][cp10]. A kidney metastasis exhibited the following karyotypic abnormalities: 46,XY,add(3)(p11),+der(3)t(3;?;11)(3qter→3p11::?::11q13→11qter), −5,del(8)(p21),add(9)(q22),del(9)(p22),der(11)t(3;11)(p21;p15),del(12)(q13),+der(13)t(5;13) (q13;q34),−22. To our knowledge, this is the first reported case of OFMT in which clonal chromosomal aberrations have been shown. |
| doi_str_mv | 10.1016/S0165-4608(01)00581-7 |
| format | Article |
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[7],+6
[5],+del(8)(p21),del(9)(p22),+10,der(11)t(3;11)(p21;p15),del(12) (q13),der(13)t(5;13)(q13;q34),+18
[6],+19,+20,−22
[5][cp10]. A kidney metastasis exhibited the following karyotypic abnormalities: 46,XY,add(3)(p11),+der(3)t(3;?;11)(3qter→3p11::?::11q13→11qter), −5,del(8)(p21),add(9)(q22),del(9)(p22),der(11)t(3;11)(p21;p15),del(12)(q13),+der(13)t(5;13) (q13;q34),−22. To our knowledge, this is the first reported case of OFMT in which clonal chromosomal aberrations have been shown.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/S0165-4608(01)00581-7</identifier><identifier>PMID: 11943338</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Chromosome Aberrations ; Dermatology ; Fibroma, Ossifying - genetics ; Fibroma, Ossifying - pathology ; Humans ; Immunoenzyme Techniques ; Karyotyping ; Kidney Neoplasms - genetics ; Kidney Neoplasms - secondary ; Lung Neoplasms - genetics ; Lung Neoplasms - secondary ; Male ; Medical sciences ; Middle Aged ; Soft Tissue Neoplasms - genetics ; Soft Tissue Neoplasms - pathology ; Tumors of the skin and soft tissue. Premalignant lesions ; X Chromosome - genetics ; Y Chromosome - genetics</subject><ispartof>Cancer genetics and cytogenetics, 2002-03, Vol.133 (2), p.124-128</ispartof><rights>2002 Elsevier Science Inc.</rights><rights>2002 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-c6dc99613a75a90dee7218a259ecb4e086262afa31c87cffb80e07566434f18f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165460801005817$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13595350$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11943338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishio, Jun</creatorcontrib><creatorcontrib>Iwasaki, Hiroshi</creatorcontrib><creatorcontrib>Ohjimi, Yuko</creatorcontrib><creatorcontrib>Ishiguro, Masako</creatorcontrib><creatorcontrib>Isayama, Teruto</creatorcontrib><creatorcontrib>Naito, Masatoshi</creatorcontrib><creatorcontrib>Okabayashi, Hiroshi</creatorcontrib><creatorcontrib>Kaneko, Yasuhiko</creatorcontrib><creatorcontrib>Kikuchi, Masahiro</creatorcontrib><title>Ossifying fibromyxoid tumor of soft parts.: Cytogenetic findings</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>Ossifying fibromyxoid tumor (OFMT) of soft parts is a recently described, rare but morphologically distinctive soft tissue tumor. The histogenesis of this lesion remains uncertain, although several immunohistochemical and ultrastructural features suggest that it is an unusual neural tumor, possibly of Schwann cell origin. We report here a case of a malignant variant of OFMT that occurred in the foot of a 52-year-old man. The karyotype of a pulmonary metastasis exhibited the following complex numeric and structural aberrations:72∼74,XXY,−5
[7],+6
[5],+del(8)(p21),del(9)(p22),+10,der(11)t(3;11)(p21;p15),del(12) (q13),der(13)t(5;13)(q13;q34),+18
[6],+19,+20,−22
[5][cp10]. A kidney metastasis exhibited the following karyotypic abnormalities: 46,XY,add(3)(p11),+der(3)t(3;?;11)(3qter→3p11::?::11q13→11qter), −5,del(8)(p21),add(9)(q22),del(9)(p22),der(11)t(3;11)(p21;p15),del(12)(q13),+der(13)t(5;13) (q13;q34),−22. To our knowledge, this is the first reported case of OFMT in which clonal chromosomal aberrations have been shown.</description><subject>Biological and medical sciences</subject><subject>Chromosome Aberrations</subject><subject>Dermatology</subject><subject>Fibroma, Ossifying - genetics</subject><subject>Fibroma, Ossifying - pathology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Karyotyping</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - secondary</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - secondary</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Soft Tissue Neoplasms - genetics</subject><subject>Soft Tissue Neoplasms - pathology</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>X Chromosome - genetics</subject><subject>Y Chromosome - genetics</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0UtLAzEQB_Agiq3Vj6DsRdHD1mTzXC8qxRcUelDPIc1OSqS7qclW7Ld3-1AvM5ffDMz8EToleEgwEdevXeE5E1hdYnKFMVckl3uoT5SkOWNc7KP-H-mho5Q-MMayKMUh6hFSMkqp6qO7SUrerXwzy5yfxlCvvoOvsnZZh5gFl6Xg2mxhYpuGN9lo1YYZNNB62-mm6qbSMTpwZp7gZNcH6P3x4W30nI8nTy-j-3FuKeNtbkVly1IQaiQ3Ja4AZEGUKXgJdsoAK1GIwjhDiVXSOjdVGLDkQjDKHFGODtDFdu8ihs8lpFbXPlmYz00DYZm0JKJQhPEOnu3gclpDpRfR1yau9O_NHTjfAZOsmbtoGuvTv6O85JTjzt1uHXRnfXmIOlkPjYXKR7CtroLXBOt1GnqThl6_WmOiN2loSX8AQlN6YQ</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Nishio, Jun</creator><creator>Iwasaki, Hiroshi</creator><creator>Ohjimi, Yuko</creator><creator>Ishiguro, Masako</creator><creator>Isayama, Teruto</creator><creator>Naito, Masatoshi</creator><creator>Okabayashi, Hiroshi</creator><creator>Kaneko, Yasuhiko</creator><creator>Kikuchi, Masahiro</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Ossifying fibromyxoid tumor of soft parts.: Cytogenetic findings</title><author>Nishio, Jun ; Iwasaki, Hiroshi ; Ohjimi, Yuko ; Ishiguro, Masako ; Isayama, Teruto ; Naito, Masatoshi ; Okabayashi, Hiroshi ; Kaneko, Yasuhiko ; Kikuchi, Masahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-c6dc99613a75a90dee7218a259ecb4e086262afa31c87cffb80e07566434f18f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Chromosome Aberrations</topic><topic>Dermatology</topic><topic>Fibroma, Ossifying - genetics</topic><topic>Fibroma, Ossifying - pathology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Karyotyping</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - secondary</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - secondary</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Soft Tissue Neoplasms - genetics</topic><topic>Soft Tissue Neoplasms - pathology</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>X Chromosome - genetics</topic><topic>Y Chromosome - genetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Nishio, Jun</creatorcontrib><creatorcontrib>Iwasaki, Hiroshi</creatorcontrib><creatorcontrib>Ohjimi, Yuko</creatorcontrib><creatorcontrib>Ishiguro, Masako</creatorcontrib><creatorcontrib>Isayama, Teruto</creatorcontrib><creatorcontrib>Naito, Masatoshi</creatorcontrib><creatorcontrib>Okabayashi, Hiroshi</creatorcontrib><creatorcontrib>Kaneko, Yasuhiko</creatorcontrib><creatorcontrib>Kikuchi, Masahiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishio, Jun</au><au>Iwasaki, Hiroshi</au><au>Ohjimi, Yuko</au><au>Ishiguro, Masako</au><au>Isayama, Teruto</au><au>Naito, Masatoshi</au><au>Okabayashi, Hiroshi</au><au>Kaneko, Yasuhiko</au><au>Kikuchi, Masahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ossifying fibromyxoid tumor of soft parts.: Cytogenetic findings</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>133</volume><issue>2</issue><spage>124</spage><epage>128</epage><pages>124-128</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>Ossifying fibromyxoid tumor (OFMT) of soft parts is a recently described, rare but morphologically distinctive soft tissue tumor. The histogenesis of this lesion remains uncertain, although several immunohistochemical and ultrastructural features suggest that it is an unusual neural tumor, possibly of Schwann cell origin. We report here a case of a malignant variant of OFMT that occurred in the foot of a 52-year-old man. The karyotype of a pulmonary metastasis exhibited the following complex numeric and structural aberrations:72∼74,XXY,−5
[7],+6
[5],+del(8)(p21),del(9)(p22),+10,der(11)t(3;11)(p21;p15),del(12) (q13),der(13)t(5;13)(q13;q34),+18
[6],+19,+20,−22
[5][cp10]. A kidney metastasis exhibited the following karyotypic abnormalities: 46,XY,add(3)(p11),+der(3)t(3;?;11)(3qter→3p11::?::11q13→11qter), −5,del(8)(p21),add(9)(q22),del(9)(p22),der(11)t(3;11)(p21;p15),del(12)(q13),+der(13)t(5;13) (q13;q34),−22. To our knowledge, this is the first reported case of OFMT in which clonal chromosomal aberrations have been shown.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11943338</pmid><doi>10.1016/S0165-4608(01)00581-7</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences Chromosome Aberrations Dermatology Fibroma, Ossifying - genetics Fibroma, Ossifying - pathology Humans Immunoenzyme Techniques Karyotyping Kidney Neoplasms - genetics Kidney Neoplasms - secondary Lung Neoplasms - genetics Lung Neoplasms - secondary Male Medical sciences Middle Aged Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - pathology Tumors of the skin and soft tissue. Premalignant lesions X Chromosome - genetics Y Chromosome - genetics |
| title | Ossifying fibromyxoid tumor of soft parts.: Cytogenetic findings |
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