Antidepressant-Like Effects of Psoralen Isolated from the Seeds of Psoralea corylifolia in the Mouse Forced Swimming Test
The forced swimming test (FST) is suggested to produce abnormalities in the serotonergic and hypothalamic–pituitary–adrenal (HPA) axis systems. Therefore, compounds that attenuate these neurobiological alterations may have potential as antidepressants. The behavioral and biochemical effects of psora...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2008/06/01, Vol.31(6), pp.1109-1114 |
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| creator | Xu, Qun Pan, Ying Yi, Li-Tao Li, Yu-Cheng Mo, Shi-Fu Jiang, Fu-Xin Qiao, Chun-Feng Xu, Hong-Xi Lu, Xiao-Bo Kong, Ling-Dong Kung, Hsiang-Fu |
| description | The forced swimming test (FST) is suggested to produce abnormalities in the serotonergic and hypothalamic–pituitary–adrenal (HPA) axis systems. Therefore, compounds that attenuate these neurobiological alterations may have potential as antidepressants. The behavioral and biochemical effects of psoralen, a major furocoumarin isolated from Psoralea corylifolia, were investigated in the FST model of depression in male mice. Psoralen significantly reduced immobility and increased swimming without altering climbing in the mouse FST. Psoralen remarkably reversed FST-induced alterations in serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in frontal cortex and hippocampus in mice. Furthermore, psoralen attenuated FST-induced elevations in serum corticotropin-releasing factor (CRF) and corticosterone concentrations to normalize the HPA axis activity. These results suggested that psoralen possessed potent antidepressant-like properties which were at least in part mediated by improving the abnormalities in the serotonergic and the HPA axis systems. |
| doi_str_mv | 10.1248/bpb.31.1109 |
| format | Article |
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Therefore, compounds that attenuate these neurobiological alterations may have potential as antidepressants. The behavioral and biochemical effects of psoralen, a major furocoumarin isolated from Psoralea corylifolia, were investigated in the FST model of depression in male mice. Psoralen significantly reduced immobility and increased swimming without altering climbing in the mouse FST. Psoralen remarkably reversed FST-induced alterations in serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in frontal cortex and hippocampus in mice. Furthermore, psoralen attenuated FST-induced elevations in serum corticotropin-releasing factor (CRF) and corticosterone concentrations to normalize the HPA axis activity. These results suggested that psoralen possessed potent antidepressant-like properties which were at least in part mediated by improving the abnormalities in the serotonergic and the HPA axis systems.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.31.1109</identifier><identifier>PMID: 18520040</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Antidepressive Agents ; Corticosterone - cerebrospinal fluid ; Corticotropin-Releasing Hormone - cerebrospinal fluid ; Drug Evaluation, Preclinical ; forced swimming test ; Furocoumarins - isolation & purification ; Furocoumarins - pharmacology ; Hydroxyindoleacetic Acid - metabolism ; hypothalamic–pituitary–adrenal axis ; Male ; Mice ; Mice, Inbred ICR ; Motor Activity - drug effects ; Psoralea ; Psoralea - chemistry ; psoralen ; Restraint, Physical ; serotonin ; Serotonin - metabolism ; Swimming - psychology</subject><ispartof>Biological and Pharmaceutical Bulletin, 2008/06/01, Vol.31(6), pp.1109-1114</ispartof><rights>2008 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c719t-2313cf304719edb5a0acf5362d03da1fdc2659c1a6b01ed927044cc4e3a36d683</citedby><cites>FETCH-LOGICAL-c719t-2313cf304719edb5a0acf5362d03da1fdc2659c1a6b01ed927044cc4e3a36d683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18520040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Qun</creatorcontrib><creatorcontrib>Pan, Ying</creatorcontrib><creatorcontrib>Yi, Li-Tao</creatorcontrib><creatorcontrib>Li, Yu-Cheng</creatorcontrib><creatorcontrib>Mo, Shi-Fu</creatorcontrib><creatorcontrib>Jiang, Fu-Xin</creatorcontrib><creatorcontrib>Qiao, Chun-Feng</creatorcontrib><creatorcontrib>Xu, Hong-Xi</creatorcontrib><creatorcontrib>Lu, Xiao-Bo</creatorcontrib><creatorcontrib>Kong, Ling-Dong</creatorcontrib><creatorcontrib>Kung, Hsiang-Fu</creatorcontrib><creatorcontrib>aState Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University</creatorcontrib><creatorcontrib>bCenter for Emerging Infectious Diseases Faculty of Medicine The Chinese University of Hong Kong</creatorcontrib><creatorcontrib>cChinese Medicine Laboratory Hong Kong Jockey Club Institute of Chinese Medicine</creatorcontrib><title>Antidepressant-Like Effects of Psoralen Isolated from the Seeds of Psoralea corylifolia in the Mouse Forced Swimming Test</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The forced swimming test (FST) is suggested to produce abnormalities in the serotonergic and hypothalamic–pituitary–adrenal (HPA) axis systems. Therefore, compounds that attenuate these neurobiological alterations may have potential as antidepressants. The behavioral and biochemical effects of psoralen, a major furocoumarin isolated from Psoralea corylifolia, were investigated in the FST model of depression in male mice. Psoralen significantly reduced immobility and increased swimming without altering climbing in the mouse FST. Psoralen remarkably reversed FST-induced alterations in serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in frontal cortex and hippocampus in mice. Furthermore, psoralen attenuated FST-induced elevations in serum corticotropin-releasing factor (CRF) and corticosterone concentrations to normalize the HPA axis activity. These results suggested that psoralen possessed potent antidepressant-like properties which were at least in part mediated by improving the abnormalities in the serotonergic and the HPA axis systems.</description><subject>Animals</subject><subject>Antidepressive Agents</subject><subject>Corticosterone - cerebrospinal fluid</subject><subject>Corticotropin-Releasing Hormone - cerebrospinal fluid</subject><subject>Drug Evaluation, Preclinical</subject><subject>forced swimming test</subject><subject>Furocoumarins - isolation & purification</subject><subject>Furocoumarins - pharmacology</subject><subject>Hydroxyindoleacetic Acid - metabolism</subject><subject>hypothalamic–pituitary–adrenal axis</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Motor Activity - drug effects</subject><subject>Psoralea</subject><subject>Psoralea - chemistry</subject><subject>psoralen</subject><subject>Restraint, Physical</subject><subject>serotonin</subject><subject>Serotonin - metabolism</subject><subject>Swimming - psychology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EotvCiTuyhMQFZZmJna8bVdUtlRaB1HK2HGfSenHixc4K7X-Pu9lSxIXLWNb85s0bPcbeICwxl_XHdtsuBS4RoXnGFihklRU5Fs_ZAhqssxKL-oSdxrgBgApy8ZKdYF3kABIWbH8-TrajbaAY9Thla_uD-GXfk5ki9z3_Fn3QjkZ-Hb3TE3W8D37g0z3xG6Lub0Zz48Pe2d47q7kdD9AXv4vEVz6YNHrzyw6DHe_4LcXpFXvRaxfp9fE9Y99Xl7cXn7P116vri_N1ZipspiwXKEwvQKYfdW2hQZu-EGXegeg09p3Jy6IxqMsWkLomr0BKYyQJLcqurMUZez_rboP_uUuL1WCjIef0SMmcqrDMqwqL_4LYSISygAS--wfc-F0Y0xEKpWxE2SSvifowUyb4GAP1ahvsoMNeIaiH4FQKTglUD8El-u1Rc9cO1D2xx6QSsJqB1LVGOz86O9LTZhOr1nrnVcJrBSCSVwUoDvKpoMxrKGqZhD7NQps46Tv6s0mHyRpHj67KuRymH1vmXgdFo_gNdZfAjg</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Xu, Qun</creator><creator>Pan, Ying</creator><creator>Yi, Li-Tao</creator><creator>Li, Yu-Cheng</creator><creator>Mo, Shi-Fu</creator><creator>Jiang, Fu-Xin</creator><creator>Qiao, Chun-Feng</creator><creator>Xu, Hong-Xi</creator><creator>Lu, Xiao-Bo</creator><creator>Kong, Ling-Dong</creator><creator>Kung, Hsiang-Fu</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Antidepressant-Like Effects of Psoralen Isolated from the Seeds of Psoralea corylifolia in the Mouse Forced Swimming Test</title><author>Xu, Qun ; 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Therefore, compounds that attenuate these neurobiological alterations may have potential as antidepressants. The behavioral and biochemical effects of psoralen, a major furocoumarin isolated from Psoralea corylifolia, were investigated in the FST model of depression in male mice. Psoralen significantly reduced immobility and increased swimming without altering climbing in the mouse FST. Psoralen remarkably reversed FST-induced alterations in serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels in frontal cortex and hippocampus in mice. Furthermore, psoralen attenuated FST-induced elevations in serum corticotropin-releasing factor (CRF) and corticosterone concentrations to normalize the HPA axis activity. These results suggested that psoralen possessed potent antidepressant-like properties which were at least in part mediated by improving the abnormalities in the serotonergic and the HPA axis systems.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>18520040</pmid><doi>10.1248/bpb.31.1109</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antidepressive Agents Corticosterone - cerebrospinal fluid Corticotropin-Releasing Hormone - cerebrospinal fluid Drug Evaluation, Preclinical forced swimming test Furocoumarins - isolation & purification Furocoumarins - pharmacology Hydroxyindoleacetic Acid - metabolism hypothalamic–pituitary–adrenal axis Male Mice Mice, Inbred ICR Motor Activity - drug effects Psoralea Psoralea - chemistry psoralen Restraint, Physical serotonin Serotonin - metabolism Swimming - psychology |
| title | Antidepressant-Like Effects of Psoralen Isolated from the Seeds of Psoralea corylifolia in the Mouse Forced Swimming Test |
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